Overview
| Uniprot ID | E9PT90 |
|---|
| Protein Name | Spartin |
|---|
| Gene Name | Spart |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 576 |
QGLECAAKCIVNNVS |
Function
Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons. Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy. Lipid transfer protein required for lipid droplet degradation, including by lipophagy. Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown. May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis
Protein Sequence
10
MNGARAFEME
20
RGAENGEPPE
30
MKIIKEAYEK
40
AFMFVNKGLN
50
TDELGQKEEA
60
KTYYKQGIGH
70
LLRGISIAAA
80
EPGHTGPAWE
90
AARQMQQKMK
100
ETLQNVRTRL
110
EILEKGLATS
120
LRNDLQDVPK
130
LYPEFPPKGT
140
CKKSPEAESA
150
PQHAEVDGSA
160
SAAGAGPSAA
170
PSALPLPSPG
180
CPAEAPPAYT
190
PQAAEGHYTV
200
SYGTDSGEFS
210
SVGEDFYRNR
220
SQPPPLETLG
230
LDADELILIP
240
NGVQIFFVNP
250
AGEVSAPSYP
260
GYLRIVRFLD
270
NSLDTVLNRP
280
PGFLQVCDWL
290
YPLVPDRSPV
300
LKCTVGAYMF
310
PDTMLQAAGC
320
FVGVVLSSEL
330
PEDDRELFED
340
LLRQMSDLRL
350
QANWNREEEE
360
EEEEEEDEFQ
370
IPGRVKELPK
380
EASGTDVRQS
390
SSSGSSIDQG
400
SKDARHKGKR
410
GKKTKDSSSE
420
EVNLRQIVPC
430
EPSSEEKSKD
440
LPEWSEKVAH
450
NILSGASWVS
460
WGLVKGAEFT
470
GKAIQKGASK
480
LRERIQPEEK
490
PVEVSPAVTR
500
GLYIAKQATG
510
GAAKVSQFLV
520
DGVCTVANCV
530
GKELAPHVKK
540
HGSKLVPESL
550
KRDKDGKSTL
560
DGAMVVAASS
570
VQGFSTVWQG
580
LECAAKCIVN
590
NVSAETVQTV
600
RYKYGHNAGE
610
ATHNAVDSAI
620
NVGVTAYNID
630
NIGIKAMVKK
640
TAKQTGHTLL
650
EDYQIIESPQ
660
RESQGGATST
670
EGTRDVERKM
680
EEEKKGAKKK
DK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005811 |
lipid droplet |
| Cellular Component |
GO:0030496 |
midbody |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0008289 |
lipid binding |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Biological Process |
GO:0060612 |
adipose tissue development |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0034389 |
lipid droplet organization |
| Biological Process |
GO:0006869 |
lipid transport |
| Biological Process |
GO:0061724 |
lipophagy |
| Biological Process |
GO:0061952 |
midbody abscission |
| Biological Process |
GO:0030514 |
negative regulation of BMP signaling pathway |
| Biological Process |
GO:0048698 |
negative regulation of collateral sprouting in absence of injury |
| Biological Process |
GO:0050905 |
neuromuscular process |
| Biological Process |
GO:0051881 |
regulation of mitochondrial membrane potential |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.