Search Results

Overview

Uniprot ID	E9PU01
Protein Name	ATP-dependent chromatin remodeler CHD4
Gene Name	Chd4
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
290	AKKPKPKKVAPLKIK
297	KVAPLKIKLGGFGSK

Function

ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis

Protein Sequence

10 MASGLGSPSP 20 CSAGSEEEDM 30 DALLNNSLPP 40 PHPENEDDPE 50 EDLSEAETPK 60 LKKKKKPKKP 70 RDPKIPKSKR 80 QKKERLLLCR 90 QLGDSSGEGP 100 EFVEEDEEAA 110 LRSDSEGSDY 120 TPGKKKKKKL 130 GPKKEKKSKS 140 KRKEEEEEED 150 DDDDSKEPKS 160 SAQLLEDWGM 170 EDIDHVFSEE 180 DYRTLTNYKA 190 FSQFVRPLIA 200 AKNPKIAVSK 210 MMMVLGAKWR 220 EFSTNNPFKG 230 SSGASVAAAA 240 AAAVAVVESM 250 VTATEVAPPP 260 PPVEVPIRKA 270 KTKEGKGPNA 280 RRKPKGSPRV 290 PDAKKPKPKK 300 VAPLKIKLGG 310 FGSKRKRSSS 320 EDDDLDVESD 330 FDDASINSYS 340 VSDGSTSRSS 350 RSRKKLRTAK 360 KKKKGEEEVT 370 AVDGYETDHQ 380 DYCEVCQQGG 390 EIILCDTCPR 400 AYHMVCLDPD 410 MEKAPEGKWS 420 CPHCEKEGIQ 430 WEAKEDNSEG 440 EEILEEVGGD 450 PEEEDDHHME 460 FCRVCKDGGE 470 LLCCDTCPSS 480 YHIHCLNPPL 490 PEIPNGEWLC 500 PRCTCPALKG 510 KVQKILIWKW 520 GQPPSPTPVP 530 RPPDADPNTP 540 SPKPLEGRPE 550 RQFFVKWQGM 560 SYWHCSWVSE 570 LQLELHCQVM 580 FRNYQRKNDM 590 DEPPSGDFGG 600 DEEKSRKRKN 610 KDPKFAEMEE 620 RFYRYGIKPE 630 WMMIHRILNH 640 SVDKKGHVHY 650 LIKWRDLPYD 660 QASWESEDVE 670 IQDYDLFKQS 680 YWNHRELMRG 690 EEGRPGKKLK 700 KVKLRKLERP 710 PETPTVDPTV 720 KYERQPEYLD 730 ATGGTLHPYQ 740 MEGLNWLRFS 750 WAQGTDTILA 760 DEMGLGKTVQ 770 TAVFLYSLYK 780 EGHSKGPFLV 790 SAPLSTIINW 800 EREFEMWAPD 810 MYVVTYVGDK 820 DSRAIIRENE 830 FSFEDNAIRG 840 GKKASRMKKE 850 ASVKFHVLLT 860 SYELITIDMA 870 ILGSIDWACL 880 IVDEAHRLKN 890 NQSKFFRVLN 900 GYSLQHKLLL 910 TGTPLQNNLE 920 ELFHLLNFLT 930 PERFHNLEGF 940 LEEFADIAKE 950 DQIKKLHDML 960 GPHMLRRLKA 970 DVFKNMPSKT 980 ELIVRVELSP 990 MQKKYYKYIL 1000 TRNFEALNAR 1010 GGGNQVSLLN 1020 VVMDLKKCCN 1030 HPYLFPVAAM 1040 EAPKMPNGMY 1050 DGSALIRASG 1060 KLLLLQKMLK 1070 NLKEGGHRVL 1080 IFSQMTKMLD 1090 LLEDFLEHEG 1100 YKYERIDGGI 1110 TGNMRQEAID 1120 RFNAPGAQQF 1130 CFLLSTRAGG 1140 LGINLATADT 1150 VIIYDSDWNP 1160 HNDIQAFSRA 1170 HRIGQNKKVM 1180 IYRFVTRASV 1190 EERITQVAKK 1200 KMMLTHLVVR 1210 PGLGSKTGSM 1220 SKQELDDILK 1230 FGTEELFKDE 1240 ATDGGGDNKE 1250 GEDSSVIHYD 1260 DKAIERLLDR 1270 NQDETEDTEL 1280 QGMNEYLSSF 1290 KVAQYVVREE 1300 EMGEEEEVER 1310 EIIKQEESVD 1320 PDYWEKLLRH 1330 HYEQQQEDLA 1340 RNLGKGKRIR 1350 KQVNYNDGSQ 1360 EDRDWQDDQS 1370 DNQSDYSVAS 1380 EEGDEDFDER 1390 SEAPRRPSRK 1400 GLRNDKDKPL 1410 PPLLARVGGN 1420 IEVLGFNARQ 1430 RKAFLNAIMR 1440 YGMPPQDAFT 1450 TQWLVRDLRG 1460 KSEKEFKAYV 1470 SLFMRHLCEP 1480 GADGAETFAD 1490 GVPREGLSRQ 1500 HVLTRIGVMS 1510 LIRKKVQEFE 1520 HVNGRWSMPE 1530 LAEVEENKKM 1540 SQPGSPSPKT 1550 PTPSTPGDTQ 1560 PNTPAPVPPA 1570 EDGIKIEENS 1580 LKEEESTEGE 1590 KEVKPTAPEV 1600 TVECAQPPAP 1610 APAPASGPGP 1620 TPGPAPAPED 1630 DKAPAEPPEG 1640 EEKVEKAEVK 1650 ERAEEPMETE 1660 SKGTTEVEKA 1670 EEKSAVDLTP 1680 IVVEDKEEKK 1690 EEEEKKEVLL 1700 QNGETPKDLS 1710 DEKQKKNLKQ 1720 RFMFNIADGG 1730 FTELHSLWQN 1740 EERAATVTKK 1750 TYEIWHRRHD 1760 YWLLAGIINH 1770 GYARWQDIQN 1780 DPRYAILNEP 1790 FKGEMNRGNF 1800 LEIKNKFLAR 1810 RFKLLEQALV 1820 IEEQLRRAAY 1830 LNMSEDPSHP 1840 SMALNTRFAE 1850 VECLAESHQH 1860 LSKESMAGNK 1870 PANAVLHKVL 1880 KQLEELLSDM 1890 KADVTRLPAT 1900 IARIPPVAVR 1910 LQMSERNILS 1920 RLANRAPEPP PQQVAQQQ

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0003682	chromatin binding
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0150048	cerebellar granule cell to Purkinje cell synapse
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0000781	chromosome, telomeric region
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0016581	NuRD complex
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0032993	protein-DNA complex
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex
Cellular Component	GO:0090734	site of DNA damage
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0140658	ATP-dependent chromatin remodeler activity
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0140297	DNA-binding transcription factor binding
Molecular Function	GO:0042393	histone binding
Molecular Function	GO:0042826	histone deacetylase binding
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function	GO:0001221	transcription coregulator binding
Molecular Function	GO:0003714	transcription corepressor activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0000724	double-strand break repair via homologous recombination
Biological Process	GO:0010629	negative regulation of gene expression
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0051963	regulation of synapse assembly
Biological Process	GO:0072553	terminal button organization

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.