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Overview

Uniprot IDE9PZQ0
Protein NameRyanodine receptor 1
Gene NameRyr1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
2361 VVRLLIRKPECFGPA
828 RLHLQPIKEYRREGP

Function

Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:18003898, PubMed:21156754, PubMed:7515481, PubMed:7621815). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain (PubMed:22036948). Required for normal embryonic development of muscle fibers and skeletal muscle (PubMed:7515481). Required for normal heart morphogenesis, skin development and ossification during embryogenesis (PubMed:18003898, PubMed:7515481)

Protein Sequence

10 MGDGGGEGED 20 EVQFLRTDDE 30 VVLQCSATVL 40 KEQLKLCLAA 50 EGFGNRLCFL 60 EPTSNAQNVP 70 PDLAICCFIL 80 EQSLSVRALQ 90 EMLANTVEAG 100 VESSQGGGHR 110 TLLYGHAILL 120 RHAHSRMYLS 130 CLTTSRSMTD 140 KLAFDVGLQE 150 DATGEACWWT 160 MHPASKQRSE 170 GEKVRVGDDL 180 ILVSVSSERY 190 LHLSTASGEL 200 QVDASFMQTL 210 WNMNPICSGC 220 EEGFVTGGHV 230 LRLFHGHMDE 240 CLTISPSDSD 250 DQRRLVYYEG 260 GPVCTHARSL 270 WRLEPLRISW 280 SGSHLRWGQP 290 LRIRHVTTGR 300 YLGLTEDQGL 310 VVVDASKAHT 320 KATSFCFRIS 330 KEKLDVAPKR 340 DVEGMGPPEI 350 KYGESLCFVQ 360 HVASGLWLTY 370 AAPDPKALRL 380 GVLKKKAMLH 390 QEGHMDDALS 400 LTRCQQEESQ 410 AARMIYSTAG 420 LYNQFIKGLD 430 SFSGKPRGSG 440 PPAGSALPIE 450 GVILSLQDLI 460 GYFEPPSEEL 470 QHEEKQTKLR 480 SLRNRQSLFQ 490 EEGMLSLVLN 500 CIDRLNVYTT 510 AAHFAEFAGE 520 EAAESWKEIV 530 NLLYELLASL 540 IRGNRTNCAL 550 FSTNLDWLVS 560 KLDRLEASSG 570 ILEVLYCVLI 580 ESPEVLNIIQ 590 ENHIKSIISL 600 LDKHGRNHKV 610 LDVLCSLCVC 620 NGVAVRSNQD 630 LITENLLPGR 640 ELLLQTNLIN 650 YVTSIRPNIF 660 VGRAEGSTQY 670 GKWYFEVMVD 680 EVAPFLTAQA 690 THLRVGWALS 700 EGYSPYPGGG 710 EGWGGNGVGD 720 DLYSYGFDGL 730 HLWTGHVARP 740 VTSPGQHLLA 750 PEDVVSCCLD 760 LSVPSISFRI 770 NGCPVQGVFE 780 SFNLDGLFFP 790 VVSFSAGIKV 800 RFLLGGRHGE 810 FKFLPPPGYA 820 PCHEAVLPRE 830 RLHLQPIKEY 840 RREGPRGPHL 850 VGPSRCLSHL 860 DFVPCPVDTI 870 QIVLPPHLER 880 IREKLAENIH 890 ELWALTRIEQ 900 GWTYGPVRDD 910 NKRLHPCLVN 920 FHSLPEPERN 930 YNLQMSGETL 940 KTLLALGCHV 950 GMADEKAEDN 960 LKKTKLPKTY 970 MMSNGYKPAP 980 LDLSHVRLTP 990 AQTTLVDRLA 1000 ENGHNVWARD 1010 RVAQGWSYSA 1020 VQDIPARRNP 1030 RLVPYRLLDE 1040 ATKRSNRDSL 1050 CQAVRTLLGY 1060 GYNIEPPDQE 1070 PSQVDSQSRG 1080 DRARIFRAEK 1090 SYAVQSGRWY 1100 FEFEAVTTGE 1110 MRVGWARPEL 1120 RPDVELGADD 1130 LAYVFNGHRG 1140 QRWHLGSEPF 1150 GRPWQSGDVV 1160 GCMIDLTENT 1170 IIFTLNGEVL 1180 MSDSGSETAF 1190 RDIEIGDGFL 1200 PVCSLGPGQV 1210 GHLNLGQDVS 1220 SLRFFAICGL 1230 QEGFEPFAIN 1240 MQRPVTTWFS 1250 KSLPQFEPVP 1260 LEHPHYEVAR 1270 MDGTVDTPPC 1280 LRLTHRTWGS 1290 QNSLVEMLFL 1300 RLSLPVQFHQ 1310 HFRCTAGATP 1320 LASPGLQPPA 1330 EDEARAAEPD 1340 TDYENLRRSA 1350 GGWGEAEGGK 1360 DGTAKEGTPG 1370 GTAQAGVEAQ 1380 PARAENEKDA 1390 TTEKNKKRGF 1400 LFKAKKVAMM 1410 TQPPSTPALP 1420 RLPRDVVPAD 1430 NRDDPEIILN 1440 TTTYYYSVRV 1450 FAGQEPSCVW 1460 VGWVTPDYHQ 1470 HDMSFDLSKV 1480 RAVTVTMGDE 1490 QGNVHSSLKC 1500 SNCYMVWGGD 1510 FVSPGQQGRI 1520 SHTDLVIGCL 1530 VDLATGLMTF 1540 TANGKESNTF 1550 FQVEPNTKLF 1560 PAVFVLPTHQ 1570 NVVQFELGKQ 1580 KNIMPLSAAM 1590 FLSERKNPAP 1600 QCPPRLEVQM 1610 LMPVSWSRMP 1620 NHFLQVDTRR 1630 AGERLGWAVQ 1640 CQEPLMMMAL 1650 HIPEENRCMD 1660 ILELSERLDL 1670 QRFHSHTLSL 1680 YRSVCALGNN 1690 RVAHALCSHV 1700 DQAQLLHALE 1710 DARLPGPLRA 1720 GYYDLLISIH 1730 LESACRSRRS 1740 MLSEYIVPLT 1750 PETRAITLFP 1760 PGRSAEDGPR 1770 RHGLPGVGVT 1780 TSLRPPHHFS 1790 PPCFVVALPA 1800 AGATEAPARL 1810 SPAIPLEALR 1820 DKALRMLGEA 1830 VRDGGQHARD 1840 PVGGSVEFQF 1850 VPVLKLVSTL 1860 LVMGVFSDED 1870 VKQILKMIEP 1880 EVFREEEEVE 1890 EEGEEEEEDE 1900 EEKEEDEEEE 1910 AHEKEDEEKE 1920 EAEDAAEEEK 1930 EELEEGLLQM 1940 KLPESVKLQM 1950 CHLLEYFCDQ 1960 ELQHRVESLA 1970 AFAECYVDKM 1980 QGNQRGRYGL 1990 LMKAFTMSAA 2000 ETARRTREFR 2010 SPPQEQINML 2020 LHFKNGADEE 2030 ECPLPEEIRQ 2040 ELVNFHQDLL 2050 AHCGIQLEGE 2060 EEEPEEESTL 2070 GSRLMSLLEK 2080 VKLVKKTEEK 2090 PEEEPAPEEH 2100 KPQSLQELVS 2110 HTVVRWAQED 2120 FVQSPELVRA 2130 MFSLLHRQYD 2140 GLGELLRALP 2150 RAYTISVSSV 2160 EDTMSLLECL 2170 GQIRSLLIVQ 2180 MGPQEENLMI 2190 QSIGNIMNNK 2200 VFYQHPNLMR 2210 ALGMHETVME 2220 VMVNVLGGGE 2230 SKEIRFPKMV 2240 TSCCRFLCYF 2250 CRISRQNQRS 2260 MFDHLSYLLE 2270 NSGIGLGMQG 2280 STPLDVAAAS 2290 VIDNNELALA 2300 LQEQDLEKVV 2310 SYLAGCGLQS 2320 CPMLLAKGYP 2330 DIGWNPCGGE 2340 RYLDFLRFAV 2350 FVNGESVEEN 2360 ANVVVRLLIR 2370 KPECFGPALR 2380 GEGGSGLLAA 2390 IEEAIRISED 2400 PARDGPGVRR 2410 DRRREHFGEE 2420 PPEENRVHLG 2430 HAIMSFYAAL 2440 IDLLGRCAPE 2450 THLIQAGKGE 2460 ALRIRAILRS 2470 LVPLDDLVGI 2480 ISLPLQIPTL 2490 GKDGALVQPK 2500 MSASFVPDHK 2510 ASMVLFLDRV 2520 YGIENQDFLL 2530 HVLDVGFLPD 2540 MRAAASLDTA 2550 TFSTTEMALA 2560 LNRYLCLAVL 2570 PLITKCAPLF 2580 AGTEHRAIMV 2590 DSMLHTVYRL 2600 SRGRSLTKAQ 2610 RDVIEDCLMA 2620 LCRYIRPSML 2630 QHLLRRLVFD 2640 VPILNEFAKM 2650 PLKLLTNHYE 2660 RCWKYYCLPT 2670 GWANFGVTSE 2680 EELHLTRKLF 2690 WGIFDSLAHK 2700 KYDQELYRIA 2710 MPCLCAIAGA 2720 LPPDYVDASY 2730 SSKTEKKATV 2740 DAEGNFDPRP 2750 VETLNVIIPE 2760 KLDSFINKFA 2770 EYTHEKWAFD 2780 KIQNNWSYGE 2790 NIDEELKTHP 2800 MLRPYKTFSE 2810 KDKEIYRWPI 2820 KESLKAMIAW 2830 EWTVEKAREG 2840 EEEKTEKKKT 2850 RKISQTAQTY 2860 DPREGYNPQP 2870 PDLSVVTLSR 2880 ELQAMAEQLA 2890 ENYHNTWGRK 2900 KKQELEAKGG 2910 GSHPLLVPYD 2920 TLTAKEKARD 2930 REKAQELLKF 2940 LQMNGYAVTR 2950 GLKDMELDTS 2960 SIEKRFAFGF 2970 LQQLLRWMDI 2980 SQEFIAHLEA 2990 VVSSGRVEKS 3000 PHEQEIKFFA 3010 KILLPLINQY 3020 FTNHCLYFLS 3030 TPAKVLGSGG 3040 HASNKEKEMI 3050 TSLFCKLAAL 3060 VRHRVSLFGT 3070 DAPAVVNCLH 3080 ILARSLDART 3090 VMKSGPEIVK 3100 AGLRSFFESA 3110 SEDIEKMVEN 3120 LRLGKVSQAR 3130 TQVKGVGQNL 3140 TYTTVALLPV 3150 LTTLFQHIAQ 3160 HQFGDDVILD 3170 DVQVSCYRTL 3180 CSIYSLGTTR 3190 NPYVEKLRPA 3200 LGECLARLAA 3210 AMPVAFLEPE 3220 LNEYNACSVY 3230 TTKSPRERAI 3240 LGLPNSVEEM 3250 CPDIPVLERL 3260 MAEIGGLAES 3270 GARYTEMPHV 3280 IEITLPMLCS 3290 YLPRWWERGP 3300 EAPPPALPAG 3310 APPPCTAVTS 3320 DHLNSLLGNI 3330 LRIIVNNLGI 3340 DEASWMKRLA 3350 VFAQPIVSRA 3360 RPELLRSHFI 3370 PTIGRLRKRA 3380 GKVVAEEEQL 3390 RLEAKAEAEE 3400 GELLVRDEFS 3410 VLCRDLYALY 3420 PLLIRYVDNN 3430 RAHWLTEPNP 3440 NAEELFRMVG 3450 EIFIYWSKSH 3460 NFKREEQNFV 3470 VQNEINNMSF 3480 LTADNKSKMA 3490 KAGDVQSGGS 3500 DQERTKKKRR 3510 GDRYSVQTSL 3520 IVATLKKMLP 3530 IGLNMCAPTD 3540 QDLIVLAKAR 3550 YALKDTDEEV 3560 REFLQNNLNL 3570 QGKVEGSPSL 3580 RWQMALYRGV 3590 PGREEDADDP 3600 EKIVRRVQEV 3610 SAVLYHLDQT 3620 EHPYKSKKAV 3630 WHKLLSKQRR 3640 RAVVACFRMT 3650 PLYNLPTHRA 3660 CNMFLESYKA 3670 SWILTEDHSF 3680 EDRMIDDLSK 3690 AGEQEEEEEE 3700 VEEKKPDPLH 3710 QLVLHFSRTA 3720 LTEKSKLDED 3730 YLYMAYADIM 3740 AKSCHLEEGG 3750 ENGEEGGEEE 3760 EVEVSFEEKE 3770 MEKQRLLYQQ 3780 SRLHNRGAAE 3790 MVLQMISACK 3800 GETGAMVSST 3810 LKLGISILNG 3820 GNAEVQQKML 3830 DYLKDKKEVG 3840 FFQSIQALMQ 3850 TCSVLDLNAF 3860 ERQNKAEGLG 3870 MVNEDGTVIN 3880 RQNGEKVMAD 3890 DEFTQDLFRF 3900 LQLLCEGHNN 3910 DFQNYLRTQT 3920 GNTTTINIII 3930 CTVDYLLRLQ 3940 ESISDFYWYY 3950 SGKDVIEEQG 3960 KRNFSKAMSV 3970 AKQVFNSLTE 3980 YIQGPCTGNQ 3990 QSLAHSRLWD 4000 AVVGFLHVFA 4010 HMMMKLAQDS 4020 SQIELLKELL 4030 DLQKDMVVML 4040 LSLLEGNVVN 4050 GMIARQMVDM 4060 LVESSSNVEM 4070 ILKFFDMFLK 4080 LKDIVGSEAF 4090 QDYVTDPRGL 4100 ISKKDFQKAM 4110 DSQKQFTGPE 4120 IQFLLSCSEA 4130 DENEMINCEE 4140 FANRFQEPAR 4150 DIGFNVAVLL 4160 TNLSEHVPHD 4170 PRLRNFLELA 4180 ESILEYFRPY 4190 LGRIEIMGAS 4200 RRIERIYFEI 4210 SETNRAQWEM 4220 PQVKESKRQF 4230 IFDVVNEGGE 4240 SEKMEMFVSF 4250 CEDTIFEMQI 4260 AAQISEPEGE 4270 PEEDEDEGAE 4280 EAEEGAAGSD 4290 GSGSAAAAGV 4300 WVWLAATAGR 4310 TLRGLSYRSL 4320 RRRVRRLRRL 4330 TAREAATAVA 4340 ALLWALVTRA 4350 GGAGAGAAAG 4360 ALRLLWGSLF 4370 GGGLVDSAKK 4380 VTVTELLAGM 4390 PDPTGDEVHG 4400 QQPSGAGSDA 4410 EGEGEGEGEG 4420 DAADGAGDEE 4430 AAADQAGTGG 4440 ADGAVAVADG 4450 SPFRPEGAGG 4460 LGDMGDTTPV 4470 EPPTPEGSPI 4480 LKRKLGVDGE 4490 EEEPPPEPEP 4500 EPEPEPEKAD 4510 TENGEKEVPE 4520 PPPEPPKKTP 4530 PPPPPKKEEA 4540 GGAGLEEFWG 4550 ELEVQRVKFL 4560 NYLSRNFYTL 4570 RFLALFLAFA 4580 INFILLFYKV 4590 SDSPPGEDDI 4600 EGSGAGDMSG 4610 AGSGDGSGWG 4620 SRAGEEVEGD 4630 EDENMVYYFL 4640 EESTGYMEPA 4650 LRCLSLLHTL 4660 VAFLCIIGYN 4670 CLKVPLVIFK 4680 REKELARKLE 4690 FDGLYITEQP 4700 EDDDVKGQWD 4710 RLVLNTPSFP 4720 SNYWDKFVKR 4730 KVLDKHGDIF 4740 GRERIAELLG 4750 MDLASLEITA 4760 HNERKPDPPP 4770 GLLTWIMSID 4780 VKYQIWKFGV 4790 IFTDNSFLYL 4800 GWYMVMSLLG 4810 HYNNFFFAAH 4820 LLDIAMGVKT 4830 LRTILSSVTH 4840 NGKQLVMTVG 4850 LLAVVVYLYT 4860 VVAFNFFRKF 4870 YNKSEDEDEP 4880 DMKCDDMMTC 4890 YLFHMYVGVR 4900 AGGGIGDEIE 4910 DPAGDEYELY 4920 RVVFDITFFF 4930 FVIVILLAII 4940 QGLIIDAFGE 4950 LRDQQEQVKE 4960 DMETKCFICG 4970 IGSDYFDTTP 4980 HGFETHTLEE 4990 HNLANYMFFL 5000 MYLINKDETE 5010 HTGQESYVWK 5020 MYQERCWDFF 5030 PAGDCFRKQY EDQLS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0034704 calcium channel complex
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0009898 cytoplasmic side of plasma membrane
Cellular Component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Cellular Component GO:0031674 I band
Cellular Component GO:0030314 junctional membrane complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0031090 organelle membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:1990425 ryanodine receptor complex
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0030017 sarcomere
Cellular Component GO:0016529 sarcoplasmic reticulum
Cellular Component GO:0033017 sarcoplasmic reticulum membrane
Cellular Component GO:0005790 smooth endoplasmic reticulum
Cellular Component GO:0030315 T-tubule
Cellular Component GO:0014802 terminal cisterna
Cellular Component GO:0031982 vesicle
Cellular Component GO:0030018 Z disc
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005262 calcium channel activity
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0048763 calcium-induced calcium release activity
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0002020 protease binding
Molecular Function GO:0005219 ryanodine-sensitive calcium-release channel activity
Molecular Function GO:0005245 voltage-gated calcium channel activity
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0071318 cellular response to ATP
Biological Process GO:0071313 cellular response to caffeine
Biological Process GO:0071277 cellular response to calcium ion
Biological Process GO:0006936 muscle contraction
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0043931 ossification involved in bone maturation
Biological Process GO:0003151 outflow tract morphogenesis
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0051480 regulation of cytosolic calcium ion concentration
Biological Process GO:0006937 regulation of muscle contraction
Biological Process GO:0047484 regulation of response to osmotic stress
Biological Process GO:0051209 release of sequestered calcium ion into cytosol
Biological Process GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Biological Process GO:0031000 response to caffeine
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0070296 sarcoplasmic reticulum calcium ion transport
Biological Process GO:0048741 skeletal muscle fiber development
Biological Process GO:0043588 skin development
Biological Process GO:0006941 striated muscle contraction

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.