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Overview

Uniprot IDE9Q401
Protein NameRyanodine receptor 2
Gene NameRyr2
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
1801 QMLTEAVKEGSLHAR

Function

Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development

Protein Sequence

10 MADAGEGEDE 20 IQFLRTDDEV 30 VLQCTATIHK 40 EQQKLCLAAE 50 GFGNRLCFLE 60 STSNSKNVPP 70 DLSICTFVLE 80 QSLSVRALQE 90 MLANTVEKSE 100 GQVDVEKWKF 110 MMKTAQGGGH 120 RTLLYGHAIL 130 LRHSYSGMYL 140 CCLSTSRSST 150 DKLAFDVGLQ 160 EDTTGEACWW 170 TIHPASKQRS 180 EGEKVRVGDD 190 LILVSVSSER 200 YLHLSYGNSS 210 WHVDAAFQQT 220 LWSVAPISSG 230 SEAAQGYLIG 240 GDVLRLLHGH 250 MDECLTVPSG 260 EHGEEQRRTV 270 HYEGGAVSVH 280 ARSLWRLETL 290 RVAWSGSHIR 300 WGQPFRLRHV 310 TTGKYLSLME 320 DKNLLLMDKE 330 KADVKSTAFA 340 FRSSKEKLDV 350 GVRKEVDGMG 360 TSEIKYGDSI 370 CYIQHVDTGL 380 WLTYQAVDVK 390 SARMGSIQRK 400 AIMHHEGHMD 410 DGLNLSRSQH 420 EESRTARVIR 430 STVFLFNRFI 440 RGLDALSKKV 450 KLPTIDLPIE 460 SVSLSLQDLI 470 GYFHPPDEHL 480 EHEDKQNRLR 490 ALKNRQNLFQ 500 EEGMINLVLE 510 CIDRLHVYSS 520 AAHFADVAGR 530 EAGESWKSIL 540 NSLYELLAAL 550 IRGNRKNCAQ 560 FSGSLDWLIS 570 RLERLEASSG 580 ILEVLHCVLV 590 ESPEALNIIK 600 EGHIKSIISL 610 LDKHGRNHKV 620 LDVLCSLCVC 630 HGVAVRSNQH 640 LICDNLLPGR 650 DLLLQTRLVN 660 HVSSMRPNIF 670 LGVSEGSAQY 680 KKWYYELMVD 690 HTEPFVTAEA 700 THLRVGWAST 710 EGYSPYPGGG 720 EEWGGNGVGD 730 DLFSYGFDGL 740 HLWSGCIART 750 VSSPNQHLLR 760 TDDVISCCLD 770 LSAPSISFRI 780 NGQPVQGMFE 790 NFNIDGLFFP 800 VVSFSAGIKV 810 RFLLGGRHGE 820 FKFLPPPGYA 830 ACYEAVLPKE 840 KLKVEHSREY 850 KQERTYTRDL 860 LGPTVSLTQA 870 AFTPVPVDTS 880 QIVLPPHLER 890 IRERLAENIH 900 ELWVMNKIEL 910 GWQYGPVRDD 920 NKRQHPCLVE 930 FCKLPEQERN 940 YNLQMSLETL 950 KTLLALGCHV 960 GIADEHAEEK 970 VKKMKLPKNY 980 QLTSGYKPAP 990 MDLSFIKLTP 1000 SQEAMVDKLA 1010 ENAHNVWARD 1020 RIRQGWTYGI 1030 QQDVKNRRNP 1040 RLVPYTLLDD 1050 RTKKSNKDSL 1060 REAVRTLLGY 1070 GYHLEAPDQD 1080 HASRAEVCSG 1090 TGERFRIFRA 1100 EKTYAVKAGR 1110 WYFEFEAVTA 1120 GDMRVGWSRP 1130 GCQPDLELGS 1140 DDRAFAFDGF 1150 KAQRWHQGNE 1160 HYGRSWQAGD 1170 VVGCMVDMNE 1180 HTMMFTLNGE 1190 ILLDDSGSEL 1200 AFKDFDVGDG 1210 FIPVCSLGVA 1220 QVGRMNFGKD 1230 VSTLKYFTIC 1240 GLQEGYEPFA 1250 VNTNRDITMW 1260 LSKRLPQFLQ 1270 VPSNHEHIEV 1280 TRIDGTIDSS 1290 PCLKVTQKSF 1300 GSQNNNTDIM 1310 FYRLSMPIEC 1320 AEVFSKSVAG 1330 GLPGAGFYGP 1340 KNDLEDFDVD 1350 SDFEVLMKTA 1360 HGHLVPDRID 1370 KDKETPKPEF 1380 NNHKDYAQEK 1390 PSRLKQRFLL 1400 RRTKPDYSTG 1410 HSARLTEDVL 1420 ADDRDDYEYL 1430 MQTSTYYYSV 1440 RIFPGQEPAN 1450 VWVGWITSDF 1460 HQYDTGFDLD 1470 RVRTVTVTLG 1480 DEKGKVHESI 1490 KRSNCYMVCA 1500 GESMSPGQGR 1510 NNSNGLEIGC 1520 VVDAASGLLT 1530 FIANGKELST 1540 YYQVEPSTKL 1550 FPAVFAQATS 1560 PNVFQFELGR 1570 IKNVMPLSAG 1580 LFKSEHKNPV 1590 PQCPPRLHVQ 1600 FLSHVLWSRM 1610 PNQFLKVDVS 1620 RISERQGWLV 1630 QCLDPLQFMS 1640 LHIPEENRSV 1650 DILELTEQEE 1660 LLQFHYHTLR 1670 LYSAVCALGN 1680 HRVAHALCSH 1690 VDEPQLLYAI 1700 ENKYMPGLLR 1710 AGYYDLLIDI 1720 HLSSYATARL 1730 MMNNEFIVPM 1740 TEETKSITLF 1750 PDENKKHGLP 1760 GIGLSTSLRP 1770 RMRFSSPSFV 1780 SISNDCYQYS 1790 PEFPLDILKA 1800 KTIQMLTEAV 1810 KEGSLHARDP 1820 VGGTTEFLFV 1830 PLIKLFYTLL 1840 IMGIFHNEDL 1850 KHILQLIEPS 1860 VFKEAAVPEE 1870 EGGTPEKEIS 1880 IEDAKLEGEE 1890 EAKGGKRPKE 1900 GLLQMKLPEP 1910 VKLQMCLLLQ 1920 YLCDCQVRHR 1930 IEAIVAFSDD 1940 FVAKLQDNQR 1950 FRYNEVMQAL 1960 NMSAALTARK 1970 TREFRSPPQE 1980 QINMLLNFKD 1990 DKSECPCPEE 2000 IRDQLLDFHE 2010 DLMTHCGIEL 2020 DEDGSLDGSN 2030 DLTIRGRLLS 2040 LVEKVTYLKK 2050 KQAEKPVASD 2060 SRKCSSLQQL 2070 ISETMVRWAQ 2080 ESVIEDPELV 2090 RAMFVLLHRQ 2100 YDGIGGLVRA 2110 LPKTYTINGV 2120 SVEDTINLLA 2130 SLGQIRSLLS 2140 VRMGKEEEKL 2150 MIRGLGDIMN 2160 NKVFYQHPNL 2170 MRALGMHETV 2180 MEVMVNVLGG 2190 GESKEITFPK 2200 MVANCCRFLC 2210 YFCRISRQNQ 2220 KAMFDHLSYL 2230 LENSSVGLAS 2240 PAMRGSTPLD 2250 VAAASVMDNN 2260 ELALALREPD 2270 LEKVVRYLAG 2280 CGLQSCQMLV 2290 SKGYPDIGWN 2300 PVEGERYLDF 2310 LRFAVFCNGE 2320 SVEENANVVV 2330 RLLIRRPECF 2340 GPALRGEGGN 2350 GLLAAMEEAI 2360 KIAEDPSRDG 2370 PSPTSGSSKT 2380 LDIEEEEDDT 2390 IHMGNAIMTF 2400 YAALIDLLGR 2410 CAPEMHLIHA 2420 GKGEAIRIRS 2430 ILRSLIPLGD 2440 LVGVISIAFQ 2450 MPTIAKDGKV 2460 VEPDMSAGFC 2470 PDHKAAMVLF 2480 LDRVYGIEVQ 2490 DFLLHLLEVG 2500 FLPDLRAAAS 2510 LDTAALSATD 2520 MALALNRYLC 2530 TAVLPLLTRC 2540 APLFAGTEHH 2550 ASLIDSLLHT 2560 VYRLSKGCSL 2570 TKAQRDSIEV 2580 CLLSICGQLR 2590 PSMMQHLLRR 2600 LVFDVPLLNE 2610 HAKMPLKLLT 2620 NHYERCWKYY 2630 CLPGGWGNFG 2640 AASEEELHLS 2650 RKLFWGIFDA 2660 LSQKKYEQEL 2670 FKLALPCLSA 2680 VAGALPPDYM 2690 ESNYVSMMEK 2700 QSSMDSEGNF 2710 NPQPVDTSNI 2720 TIPEKLEYFI 2730 NKYAEHSHDK 2740 WSMDKLANGW 2750 IYGEIYSDSS 2760 KIQPLMKPYK 2770 LLSEKEKEIY 2780 RWPIKESLKT 2790 MLAWGWRIER 2800 TREGDSMALY 2810 NRTRRISQTS 2820 QVSIDAAHGY 2830 SPRAIDMSNV 2840 TLSRDLHAMA 2850 EMMAENYHNI 2860 WAKKKKLELE 2870 SKGGGNHPLL 2880 VPYDTLTAKE 2890 KAKDREKAQD 2900 IFKFLQISGY 2910 VVSRGFKDLD 2920 LDTPSIEKRF 2930 AYSFLQQLIR 2940 YVDEAHQYIL 2950 EFDGGSRSKG 2960 EHFPYEQEIK 2970 FFAKVVLPLI 2980 DQYFKNHRLY 2990 FLSAASRPLC 3000 TGGHASNKEK 3010 EMVTSLFCKL 3020 GVLVRHRISL 3030 FGNDATSIVN 3040 CLHILGQTLD 3050 ARTVMKTGLD 3060 SVKSALRAFL 3070 DNAAEDLEKT 3080 MENLKQGQFT 3090 HTRSQPKGVT 3100 QIINYTTVAL 3110 LPMLSSLFEH 3120 IGQHQFGEDL 3130 ILEDVQVSCY 3140 RILTSLYALG 3150 TSKSIYVERQ 3160 RSALGECLAA 3170 FAGAFPIAFL 3180 ETHLDKHNVY 3190 SIYNTRSSRE 3200 RAALSLPANV 3210 EDVCPNIPSL 3220 EKLMTEIIEL 3230 AESGIRYTQM 3240 PYMMEVVLPM 3250 LCSYMSRWWE 3260 HGPENHPERA 3270 EMCCTALNSE 3280 HMNTLLGNIL 3290 KIIYNNLGID 3300 EGAWMKRLAV 3310 FSQPIINKVK 3320 PQLLKTHFLP 3330 LMEKLKKKAA 3340 MVVSEEDHLK 3350 AEARGDMSEA 3360 ELLILDEFTT 3370 LARDLYAFYP 3380 LLIRFVDYNR 3390 AKWLKEPNPE 3400 AEELFRMVAE 3410 VFIYWSKSHN 3420 FKREEQNFVV 3430 QNEINNMSFL 3440 ITDTKSKMSK 3450 AAISDQERKK 3460 MKRKGDRYSM 3470 QTSLIVAALK 3480 RLLPIGLNIC 3490 APGDQELIAL 3500 AKNRFSLKDT 3510 EEEVRDIIRS 3520 NIHLQGKLED 3530 PAIRWQMALY 3540 KDLPNRTEDP 3550 SDPERTVERV 3560 LGIANVLFHL 3570 EQKSKYTGRG 3580 YFSLVEHPQR 3590 SKKAVWHKLL 3600 SKQRKRAVVA 3610 CFRMAPLYNL 3620 PRHRAVNLFL 3630 QGYEKSWIET 3640 EEHYFEDKLI 3650 EDLAKPGAEL 3660 PEEDEAMKRV 3670 DPLHQLILLF 3680 SRTALTEKCK 3690 LEEDFLYMAY 3700 ADIMAKSCHD 3710 EEDDDGEEEV 3720 KSFEEKEMEK 3730 QKLLYQQARL 3740 HDRGAAEMVL 3750 QTISASKGET 3760 GPMVAATLKL 3770 GIAILNGGNS 3780 TVQQKMLDYL 3790 KEKKDVGFFQ 3800 SLAGLMQSCS 3810 VLDLNAFERQ 3820 NKAEGLGMVT 3830 EEGSGEKVLQ 3840 DDEFTCDLFR 3850 FLQLLCEGHN 3860 SDFQNYLRTQ 3870 TGNNTTVNII 3880 ISTVDYLLRV 3890 QESISDFYWY 3900 YSGKDIIDEQ 3910 GQRNFSKAIQ 3920 VAKQVFNTLT 3930 EYIQGPCTGN 3940 QQSLAHSRLW 3950 DAVVGFLHVF 3960 AHMQMKLSQD 3970 SSQIELLKEL 3980 MDLQKDMVVM 3990 LLSMLEGNVV 4000 NGTIGKQMVD 4010 MLVESSNNVE 4020 MILKFFDMFL 4030 KLKDLTSSDT 4040 FKEYDPDGKG 4050 VISKRDFHKA 4060 MESHKHYTQS 4070 ETEFLLSCAE 4080 TDENETLDYE 4090 EFVKRFHEPA 4100 KDIGFNVAVL 4110 LTNLSEHMPN 4120 DTRLQTFLEL 4130 AESVLNYFQP 4140 FLGRIEIMGS 4150 AKRIERVYFE 4160 ISESSRTQWE 4170 KPQVKESKRQ 4180 FIFDVVNEGG 4190 EKEKMELFVN 4200 FCEDTIFEMQ 4210 LAAQISESDL 4220 NERLANKEES 4230 EKERPEEQAP 4240 RMGFFSLLTI 4250 QSALFALRYN 4260 VLTLVRMLSL 4270 KSLKKQMKRM 4280 KKMTVKDMVL 4290 AFFSSYWSVF 4300 VTLLHFVASV 4310 CRGFFRIVSS 4320 LLLGGSLVEG 4330 AKKIKVAELL 4340 ANMPDPTQDE 4350 VRGDEEEGER 4360 KPLESALPSE 4370 DLTDLKELTE 4380 ESDLLSDIFG 4390 LDLKREGGQY 4400 KLIPHNPNAG 4410 LSDLMTNPVP 4420 VPEVQEKFQE 4430 QKAKEEKEEK 4440 EETKSEPEKA 4450 EGEDGEKEEK 4460 AKDEKSKQKL 4470 RQLHTHRYGE 4480 PEVPESAFWK 4490 KIIAYQQKLL 4500 NYFARNFYNM 4510 RMLALFVAFA 4520 INFILLFYKV 4530 STSSVVEGKE 4540 LPTRTSSDTA 4550 KVTNSLDSSP 4560 HRIIAVHYVL 4570 EESSGYMEPT 4580 LRILAILHTI 4590 ISFFCIIGYY 4600 CLKVPLVIFK 4610 REKEVARKLE 4620 FDGLYITEQP 4630 SEDDIKGQWD 4640 RLVINTQSFP 4650 NNYWDKFVKR 4660 KVMDKYGEFY 4670 GRDRISELLG 4680 MDKAALDFSD 4690 AREKKKPKKD 4700 SSLSAVLNSI 4710 DVKYQMWKLG 4720 VVFTDNSFLY 4730 LAWYMTMSVL 4740 GHYNNFFFAA 4750 HLLDIAMGFK 4760 TLRTILSSVT 4770 HNGKQLVLTV 4780 GLLAVVVYLY 4790 TVVAFNFFRK 4800 FYNKSEDGDT 4810 PDMKCDDMLT 4820 CYMFHMYVGV 4830 RAGGGIGDEI 4840 EDPAGDEYEI 4850 YRIIFDITFF 4860 FFVIVILLAI 4870 IQGLIIDAFG 4880 ELRDQQEQVK 4890 EDMETKCFIC 4900 GIGNDYFDTV 4910 PHGFETHTLQ 4920 EHNLANYLFF 4930 LMYLINKDET 4940 EHTGQESYVW 4950 KMYQERCWEF 4960 FPAGDCFRKQ YEDQLN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031672 A band
Cellular Component GO:0034704 calcium channel complex
Cellular Component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0030017 sarcomere
Cellular Component GO:0016529 sarcoplasmic reticulum
Cellular Component GO:0033017 sarcoplasmic reticulum membrane
Cellular Component GO:0005790 smooth endoplasmic reticulum
Cellular Component GO:0030018 Z disc
Molecular Function GO:0005262 calcium channel activity
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0048763 calcium-induced calcium release activity
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0015278 intracellularly gated calcium channel activity
Molecular Function GO:0034236 protein kinase A catalytic subunit binding
Molecular Function GO:0034237 protein kinase A regulatory subunit binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0005219 ryanodine-sensitive calcium-release channel activity
Molecular Function GO:0097110 scaffold protein binding
Molecular Function GO:0043924 suramin binding
Biological Process GO:0097553 calcium ion transmembrane import into cytosol
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0060402 calcium ion transport into cytosol
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0003300 cardiac muscle hypertrophy
Biological Process GO:0071313 cellular response to caffeine
Biological Process GO:0071872 cellular response to epinephrine stimulus
Biological Process GO:0005513 detection of calcium ion
Biological Process GO:0003143 embryonic heart tube morphogenesis
Biological Process GO:0072599 establishment of protein localization to endoplasmic reticulum
Biological Process GO:0006874 intracellular calcium ion homeostasis
Biological Process GO:0003220 left ventricular cardiac muscle tissue morphogenesis
Biological Process GO:0071421 manganese ion transmembrane transport
Biological Process GO:0034220 monoatomic ion transmembrane transport
Biological Process GO:0051481 negative regulation of cytosolic calcium ion concentration
Biological Process GO:0010460 positive regulation of heart rate
Biological Process GO:0051284 positive regulation of sequestering of calcium ion
Biological Process GO:0098735 positive regulation of the force of heart contraction
Biological Process GO:0086029 Purkinje myocyte to ventricular cardiac muscle cell signaling
Biological Process GO:0098910 regulation of atrial cardiac muscle cell action potential
Biological Process GO:0098904 regulation of AV node cell action potential
Biological Process GO:0055117 regulation of cardiac muscle contraction
Biological Process GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
Biological Process GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Biological Process GO:0051480 regulation of cytosolic calcium ion concentration
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0098907 regulation of SA node cell action potential
Biological Process GO:0098911 regulation of ventricular cardiac muscle cell action potential
Biological Process GO:0051209 release of sequestered calcium ion into cytosol
Biological Process GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Biological Process GO:0031000 response to caffeine
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0032026 response to magnesium ion
Biological Process GO:0014850 response to muscle activity
Biological Process GO:0035994 response to muscle stretch
Biological Process GO:0051775 response to redox state
Biological Process GO:0070296 sarcoplasmic reticulum calcium ion transport
Biological Process GO:0006941 striated muscle contraction
Biological Process GO:0097050 type B pancreatic cell apoptotic process
Biological Process GO:0086005 ventricular cardiac muscle cell action potential

Reference

[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.