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Overview

Uniprot IDE9Q557
Protein NameDesmoplakin
Gene NameDsp
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
2038 AGASASPKEKYSLVE
2047 KYSLVEAKRKKFITP
2604 SRHDSVSKISTISSV

Function

A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Critical for cell-cell adhesion in early stage blastocysts and progression through proamniotic cavity formation (PubMed:9864371). Not required for preimplantation morphogenic process in blastocysts (PubMed:9864371). Required for keratin filament anchoring at the desmosome junction and subsequent organization of the keratin intermediate filament network within the cytoplasm (PubMed:9864371). Required for anchoring of desmosomes to the microtubule architecture, via its interaction with NIN (PubMed:17227889). Promotes microtubule-mediated GJA1/CX43 trafficking to cell membranes via its interaction with MAPRE1/EB1, thereby facilitating gap junction intracellular communication (By similarity). Plays a key role in adhesion and organization of the dermal epithelial barrier (PubMed:11222147). Critical for the maintenance of the neural tube structure following formation and organization of the neuroepithelium (PubMed:11222147). Facilitates outgrowth and repair of motor neuron fibers in regenerating axons following injury, probably by promoting recruitment of a complex containing DSP, CDH2, VIM and JUP to the outgrowth tips (PubMed:25496840). Critical for the normal formation of heart and myocardial tissue during early embryogenesis (PubMed:11222147, PubMed:16917092). Also required for development of vascular capillary structures and intact endothelial cell barriers (PubMed:11222147). Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). Maintains cardiac rhythmicity by ensuring correct cell-cell adhesion within the sinoatrial node, via stabilization of protein components of both desmosome and Gap junctions (PubMed:27097650). Involved in maintaining the protein stability and recruitment of GJA1 to functional gap junctions, via inhibition of KRAS-mediated MAPK1/MAPK3 phosphorylation of GJA1 (PubMed:29959233). Negative regulator of cell cycle progression and differentiation in keratinocytes, potentially via inhibition of MAPK and phosphoinositide-3-kinase (PI3K) signaling pathways (By similarity). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (By similarity). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (By similarity). Required for the maintenance of protein abundance of desmosome junction components DSG1, DSG2, DSC2, DSC3, PKP1, PKP2 and PKP3 (By similarity). Required for the survival and maintenance of germ cells in the gonads during embryonic development (PubMed:35119382). Binds to telomere DNA (via C-terminus) and acts to prevent telomere damage and maintain telomere length via its interaction with TRF2 (By similarity)

Protein Sequence

10 MSCNGGSHPR 20 INTLGRMTRA 30 ESGPDLRYEM 40 TYSGGGGGGG 50 GGGGGGTSRT 60 FYSHSRRCTV 70 NDQNSDGYCQ 80 TGTMSRHQNQ 90 NTIQEMLQNC 100 SDCLMRAELI 110 AQPELKFGEG 120 MQLAWNRELD 130 EYFTQANDQM 140 EIIDGLIREM 150 RQMGQPCDAY 160 QKRLLQLQEQ 170 MRALYKAISV 180 PRVRRASSKG 190 AGGYTCQSGS 200 GWDEFTKRLT 210 GECLGWMRQQ 220 REEMDLMAWG 230 VDAGSVEQHI 240 NSHRSIHNTI 250 GDYRWQLDKI 260 KADLREKSAI 270 YQLEEEYENL 280 LKASFERMDH 290 LRQLQNIIQA 300 TSREIMWIND 310 CEEEELLYDW 320 SDKNTNIAQK 330 QEAFSIRMSQ 340 LEVKEKELNK 350 LKQESDQLVL 360 NQHPASDKIE 370 AYMDTLQTQW 380 SWILQITKCI 390 DVHLKENAAY 400 FQFFEEAQST 410 EAYLKGLQDS 420 IRKKYPCDKN 430 MPLQHLLEQI 440 KELEKEREKI 450 IEYKRQVQNL 460 VNKSKKIVQL 470 KPRNPDYRSN 480 KPIILRALCD 490 YKQDQKIVHK 500 GDECILKDNN 510 ERSKWYVTGP 520 GGVDMLVPSV 530 GLIIPPPNPL 540 AVDLSCKIEQ 550 YYEAILALWN 560 QLYINMKSLV 570 SWHYCMIDIE 580 KIRAMTIAKL 590 KTMRQEDYMK 600 TIEDLELHYQ 610 DFIKNSQGSE 620 MFGDDDKRRM 630 QSQFTDAQKH 640 YQTLVIQLPG 650 HPQHQTVTKT 660 EITHLGTCQD 670 VNHNKVIETN 680 RENDKQETWL 690 LMELQKIRRQ 700 MEHCEARMTL 710 KNLLLAEQGS 720 THHITVKINE 730 LKSVQNDSQA 740 LAEVLNQLKD 750 MLANFRGSEK 760 YCYLQNEIFG 770 LFQKLENING 780 VSDGYLNSLC 790 SVRALLQAIL 800 QTEDMLKVYE 810 ARLTEEETVC 820 LDLDKVEAYR 830 CGLKKIKNDL 840 NLKKSLLATM 850 KTELQKAQQI 860 HSQSSQQYPL 870 YDLDLGKFTE 880 KVTQLTDRWQ 890 KIDKQIDFRL 900 WDLEKQIKQL 910 RNYRDNYQSF 920 CKWLYDAKRR 930 QDSLESMKFG 940 DSNTVMRFLN 950 EQKNLHSEIS 960 GKRDKSEEVH 970 KIAELCANSI 980 KDYELQLASY 990 TSGLETLLNI 1000 PIKRTMVQSP 1010 SGVILQEAAD 1020 IHARYIELLT 1030 RSGDYYRFLS 1040 EMLKSLEDLK 1050 LKNTKIEVLE 1060 EELRLARDAN 1070 SENCNKNKFL 1080 DQNLQKYQAE 1090 CSQFKAKLVS 1100 LEELKRQAEL 1110 DGKSAKQNLD 1120 KCYGQIKELN 1130 EKITRLTYEI 1140 EDEKRRRKTV 1150 EDRFDQQKND 1160 YDQLQKARQC 1170 EKENLSWQKL 1180 ESEKAIKEKE 1190 YEIERLRVLL 1200 QEEGARKREY 1210 ENELAKVRNH 1220 YNEEMSNLRN 1230 KYETEINITK 1240 TTIKEISMQK 1250 EDDSKNLRNQ 1260 MDRLSRENRD 1270 LKDEIVRLND 1280 SILQATEQRR 1290 RAEENALQQK 1300 ACGSETMQKK 1310 QRLEIELKQV 1320 IQQRSEDNAR 1330 HKQSLEEAAK 1340 TIQDKNKEIE 1350 RLKAEYQEEA 1360 KRRWEYENEL 1370 SKVRNSYDEE 1380 IISLKNQFET 1390 EINITKTTIH 1400 QLTMQKEEDT 1410 SGYRAQIDNL 1420 TRENRSLCEE 1430 VKRLKNTLAQ 1440 TTENLRRVEE 1450 NAQQQKATGS 1460 EMSQRKQQLE 1470 IELRQVTQMR 1480 TEESMRYKQS 1490 LDDAAKTIQD 1500 KNKEIERLKQ 1510 LVDKETNERK 1520 CLEDENSKLQ 1530 RVQYDLQKAN 1540 NSATEAMSKL 1550 KVQEQELTRL 1560 RIDYERVSQE 1570 RTVKDQDITR 1580 IQSSLKDLQL 1590 QKQKAEEELS 1600 RLKRTASDES 1610 SKRKMLEEEL 1620 EAMRRSLKEQ 1630 AVKITNLTQQ 1640 LEQASIVKKR 1650 SEDDLRQQRD 1660 VLDGHVREKQ 1670 RTQEELRRLS 1680 LDVEALRRQL 1690 VQEQENVKQA 1700 HLRNEHFQKA 1710 IEDKSRSLNE 1720 SKIEIERLQS 1730 LTENLTKEHL 1740 MLEEELRNLR 1750 LEYDDLRRGR 1760 SEADSDKNST 1770 ISELRSQLQI 1780 SNNRTLELQG 1790 LINDLQRERE 1800 NLRQEIEKFQ 1810 KQALEASNRI 1820 QESKSQCTQV 1830 VQERESLLVK 1840 IKVLEQDKAR 1850 LQRLEDELNR 1860 AKATLEAESR 1870 VKQRLECEKQ 1880 QIQNDLNQWK 1890 TQYSRKEETI 1900 RKIESEREKS 1910 EREKNSLRSE 1920 IERLQAEIKR 1930 IEERCRRKLE 1940 DSSRETQSQL 1950 ESERCRLQKE 1960 IEKLRQRPYG 1970 SHRETQTEYE 1980 WTVDSSKLVF 1990 DGLRKKVTAM 2000 QLYECQLIDK 2010 TTLDKLLKGK 2020 KSVEEVASEI 2030 QPFLRGAGAI 2040 AGASASPKEK 2050 YSLVEAKRKK 2060 FITPESTVML 2070 LEAQAATGGI 2080 IDPHRNEKLT 2090 VDNAVARDLI 2100 DFDDRQQIYT 2110 AEKAITGFDD 2120 PFSGKTVSVS 2130 EAIKKNLIDR 2140 ETGMRLLEAQ 2150 LASGGVVDPV 2160 NSVFLPKDVA 2170 LARGLIDRDL 2180 YRSLNDPRDS 2190 QKNFVDPITK 2200 KKVSYMQLRE 2210 RCRIEPHTGL 2220 LLLSVQKRSM 2230 SFQGIRQPVT 2240 VTELVDSGIL 2250 RPSTVNELES 2260 GQISYDEVGE 2270 RIKDFLQGSS 2280 CIAGIYNETT 2290 KQKLGIYEAM 2300 KIGLVRPGTA 2310 LELLEAQAAT 2320 GFIVDPVSNL 2330 RLPVEEAYKR 2340 GLVGIEFKEK 2350 LLSAERAVTG 2360 YNDPETGNII 2370 SLFQAMNKEL 2380 IEKGHGIRLL 2390 EAQIATGGII 2400 DPKESHRLPV 2410 DMAYKRGYFN 2420 EELSEILSDP 2430 SDDTKGFFDP 2440 NTEENLTYLQ 2450 LKERCIKDEE 2460 TGLCLLPLKE 2470 KKKQVQTSQK 2480 NTLRKRRVVI 2490 VDPETNKEMS 2500 VQEAYKKGLI 2510 DYDTFKELCE 2520 QECEWEEITI 2530 TGSDGSTRVV 2540 LVDRKTGSQY 2550 DIQDAIDKGL 2560 VDRKFFDQYR 2570 SGSLSLTQFA 2580 DMISLKNGVG 2590 NSSGLGGSVN 2600 DDVFSSSRHD 2610 SVSKISTISS 2620 VRNLTIRSSS 2630 LSDPLEESSP 2640 IAAIFDTENL 2650 EKISIAEGIE 2660 RGIVDSITGQ 2670 RLLEAQACTG 2680 GIIHPTTGQK 2690 LSLQDAVNQG 2700 LIDQDMATRL 2710 KPAQKAFIGF 2720 EGVKGKKKMS 2730 AAEAVKEKWL 2740 PYEAGQRFLE 2750 FQFLTGGLVD 2760 PEVHGRISTE 2770 EAIRKGFIDG 2780 RAAQRLQDIS 2790 SYAKILTCPK 2800 TKLKISYKDA 2810 MNRSMVEDIT 2820 GLRLLEAASV 2830 SSKGLPSPYN 2840 MSAPGSRSGS 2850 RSGSRSGSRS 2860 GSRSGSRRGS 2870 FDATGNSSYS 2880 YSYSFSSSSI GGY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0030424 axon
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0030054 cell junction
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0001533 cornified envelope
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0030057 desmosome
Cellular Component GO:0005916 fascia adherens
Cellular Component GO:0014704 intercalated disc
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0005080 protein kinase C binding
Molecular Function GO:0097110 scaffold protein binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0034332 adherens junction organization
Biological Process GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0002934 desmosome organization
Biological Process GO:0090136 epithelial cell-cell adhesion
Biological Process GO:0045104 intermediate filament cytoskeleton organization
Biological Process GO:0045109 intermediate filament organization
Biological Process GO:0030216 keratinocyte differentiation
Biological Process GO:0018149 peptide cross-linking
Biological Process GO:0150105 protein localization to cell-cell junction
Biological Process GO:0086091 regulation of heart rate by cardiac conduction
Biological Process GO:0098911 regulation of ventricular cardiac muscle cell action potential
Biological Process GO:0043588 skin development
Biological Process GO:0003223 ventricular compact myocardium morphogenesis
Biological Process GO:0042060 wound healing

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.