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Overview

Uniprot ID	F1LMC7
Protein Name	Septin
Gene Name	Septin7
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
332	EHVAKMKKMEMEMEQ

Function

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation

Protein Sequence

10 MSVSARSAAA 20 EERSVNCSTM 30 GEPQPPNLEG 40 YVGFANLPNQ 50 VYRKSVKRGF 60 EFTLMVVGES 70 GLGKSTLINS 80 LFLTDLYSPE 90 YPGPSHRIKK 100 TVQVEQSKVL 110 IKEGDCCFPV 120 IDYIDSKFED 130 YLNAESRVNR 140 RQMPDNRVQC 150 CLYFIAPSGH 160 GLKPLDIEFM 170 KRLHEKVNII 180 PLIAKADTLT 190 PEECQQFKKQ 200 IMKEIQEHKI 210 KIYEFPETDD 220 EEENKLVKKI 230 KDRLPLAVVG 240 SNTIIEVNGK 250 RVRGRQYPWG 260 VAEVENGEHC 270 DFTILRNMLI 280 RTHMQDLKDV 290 TNNVHYENYR 300 SRKLAAVTYN 310 GVDNNKNKGQ 320 LTKSPLAQME 330 EERREHVAKM 340 KKMEMEMEQV 350 FEMKVKEKVQ 360 KLKDSEAELQ 370 RRHEQMKKNL 380 EAQHKELEEK 390 RRQFEEEKAN 400 WEAQQRILEQ QNSSR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005930	axoneme
Cellular Component	GO:0032154	cleavage furrow
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0030496	midbody
Cellular Component	GO:0031105	septin complex
Cellular Component	GO:0005819	spindle
Molecular Function	GO:0005525	GTP binding
Biological Process	GO:0051301	cell division

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.