Search Results
Overview
| Uniprot ID | F1LMD9 |
|---|---|
| Protein Name | Cyclin-G-associated kinase |
| Gene Name | Gak |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 388 | ERLFTNLKDTSSKVI |
Function
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly
Protein Sequence
10
MSLLQSALDF
20
LAGPGSLGGA
30
AGRDQSDFVG
40
QTVELGELRL
50
RVRRVLAEGG
60
FAFVYEAQDL
70
GSGREYALKR
80
LLSNEEEKNR
90
AIIQEVCFLK
100
KLSGHPNIVQ
110
FCSAASIGKE
120
ESDTGQAEFL
130
LLTELCKGQL
140
VEFLRRVECK
150
GPLSCDSILK
160
IFYQTCRAVQ
170
HMHRQKPPII
180
HRDLKVENLL
190
LSNQGTIKLC
200
DFGSATTISH
210
YPDYSWSAQK
220
RAMVEEEITR
230
NTTPMYRTPE
240
IVDLYSNFPI
250
GEKQDIWALG
260
CILYLLCFRQ
270
HPFEDGAKLR
280
IVNGKYSIPV
290
NDTRYTVFHD
300
LIRGMLKVNP
310
EERLSIAEVV
320
RQLQEIAAAR
330
NVNPKAPITE
340
LLEQNGGYGN
350
SGPSRAQPPS
360
GGPVNSSGVL
370
ALAEYDQPYG
380
GFLDILRGGT
390
ERLFTNLKDT
400
SSKVIQSVAN
410
YAKGDLDISY
420
ITSRIAVMSF
430
PAEGVESAIK
440
NNIEDVRLFL
450
DAKHPGHYAV
460
YNLSPRIYRA
470
SKFHNRVTEC
480
GWAVRRAPHL
490
HSLYTLCRSM
500
HAWLREDHRN
510
VCVVHCMDGR
520
AASAVAVCAF
530
LCFCRLFSTA
540
EAAVYMFSMK
550
RCPPGIWPSH
560
KRYIEYVCDM
570
VAEEPITPHS
580
KPMLVKSVVM
590
TPVPLFSKQR
600
NGCRPFCEVY
610
VGEERVTTTS
620
QEYDRMKEFK
630
IEDGKAVIPL
640
GITVQGDVLI
650
IIYHARSTLG
660
GRLQAKMASM
670
KMFQIQFHTG
680
FVPRNATTVK
690
FAKYDLDACD
700
IQEKYPDLFQ
710
VNLEVEVEPR
720
DRPSRDVPPW
730
ENTSLRGLNP
740
KILFSNREEQ
750
QDILSKFGKP
760
ELPRQPGSTA
770
QYDAEAGSPE
780
AEITESDSPQ
790
SSSTDTNHFL
800
HTLDWQEEKD
810
PETGVDNTSP
820
KESQSNLIAD
830
GDGSEVSDEE
840
EASCPSEERK
850
PGAGEDTPRL
860
AAGTRQQDLI
870
FDVGMLAAPQ
880
EPVQPEEGVD
890
LLGLHSEGDL
900
RPAAPLQASG
910
VQSSNTDLLS
920
SLLEPSDASQ
930
VGPPGDLLGG
940
ETPLLLASPV
950
SLLGVQSNLQ
960
GKVPDTVDPF
970
DQFLLPSSSD
980
TQPCSKPDLF
990
GEFLNSDSVA
1000
SSTAFPSTHS
1010
APPPSCSTAF
1020
LHLGDLPAEP
1030
NKVIASSSHP
1040
DLLGGWDTWA
1050
ETALPGPASM
1060
PVPEGTLFSS
1070
AGHPAPPGPN
1080
PSQTKSQNPD
1090
PFADLSDLSS
1100
SLQGLPAGLP
1110
AGSFVGTSAT
1120
THKSNSSWQT
1130
TRPTAPGTSW
1140
PPQAKPAPRA
1150
SEQLRSHFSV
1160
IGAREERGVR
1170
APSFAQKPKV
1180
SENDFEDLLP
1190
NQGFSKSDKK
1200
GPKTMAEMRK
1210
QELARDTDPF
1220
KLKLLDWIEG
1230
KERNIRALLS
1240
TLHTVLWDGE
1250
SRWTPVSMAD
1260
LVTPEQVKKQ
1270
YRRAVLVVHP
1280
DKATGQPYEQ
1290
SAKMIFMELN
1300
DAWSEFENQG
SRPLF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030136 | clathrin-coated vesicle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Biological Process | GO:0048268 | clathrin coat assembly |
| Biological Process | GO:0072318 | clathrin coat disassembly |
| Biological Process | GO:0072583 | clathrin-dependent endocytosis |
| Biological Process | GO:0007030 | Golgi organization |
| Biological Process | GO:0090160 | Golgi to lysosome transport |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:0034067 | protein localization to Golgi apparatus |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:1905443 | regulation of clathrin coat assembly |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.