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Overview

Uniprot IDF1LMY3
Protein NameReceptor-type tyrosine-protein phosphatase zeta
Gene NamePtprz1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
171 SSFEETVKGKGRLRA
52 NQKNWGKKYPICNSP
81 NVNLKKLKFQGWEKP

Function

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades

Protein Sequence

10 MRILQSFLAC 20 VQLLCVCRLD 30 WAYGYYRQQR 40 KLVEEIGWSY 50 TGALNQKNWG 60 KKYPICNSPK 70 QSPINIDEDL 80 TQVNVNLKKL 90 KFQGWEKPSL 100 ENTFIHNTGK 110 TVEINLTNDY 120 YLSGGLSEKV 130 FKASKMTFHW 140 GKCNVSSEGS 150 EHSLEGQKFP 160 LEMQIYCFDA 170 DRFSSFEETV 180 KGKGRLRALS 190 ILFEIGVEEN 200 LDYKAIIDGT 210 ESVSRFGKQA 220 ALDPFILQNL 230 LPNSTDKYYI 240 YNGSLTSPPC 250 TDTVEWIVFK 260 DTVSISESQL 270 AVFCEVLTMQ 280 QSGYVMLMDY 290 LQNNFREQQY 300 KFSRQVFSSY 310 TGKEEIHEAV 320 CSSEPENVQA 330 DPENYTSLLI 340 TWERPRVVYD 350 TMIEKFAVLY 360 QPLEGNDQTK 370 HEFLTDGYQD 380 LGAILNNLIP 390 NMSYVLQIVA 400 ICSNGLYGKY 410 SDQLIVDMPT 420 EDAELDLFPE 430 LIGTEEIIKE 440 EDYGKGNEED 450 TGLNPGRDSA 460 TNQIRKKEPQ 470 VSTTTHYNHM 480 GTKYNEAKTN 490 RSPTKGSEFS 500 GKSDVLNTSL 510 NPTSQQVAEF 520 NPEREMSLPS 530 QIGTNLPPHS 540 VEGTSASLNS 550 GSKTLLVFPQ 560 MNLSGTAESL 570 NMVSITEYKE 580 VSADLSEEEN 590 LLTDFKLDSG 600 ADDSSGSSPA 610 SSTVPFSTDN 620 LSHGYTSSSD 630 TPEAVTYDVL 640 RPESTRNALE 650 DSAPSGSEES 660 LKDPSLEGSV 670 WFPGSTDLTT 680 QSETGSGREG 690 FLQVNSTDFQ 700 VDESRETTET 710 FSPDATASRG 720 PSVTDMEMPH 730 YSTFAYPPTE 740 VTPHAFTPSS 750 RPLDLAPTSN 760 ILHSQTTQPV 770 YNGETPLQPS 780 YSSEVFPLVT 790 PLLLDNQTLN 800 TTPAASSSDS 810 ALHATPVFPS 820 VGVSFDSILS 830 SYDDAPLLPF 840 SSASFSSDLF 850 HHLHTVSQTL 860 PQVTSAAERD 870 ELSLHASLLV 880 AGGDLLLEPS 890 LVQYSDVMSH 900 QVTIHAASDT 910 LEFGSESAVL 920 YKTSMVSQIE 930 SPSSDVVMHA 940 YSSGPETSYA 950 IEGSHHVLTV 960 SSSSAIPVHD 970 SIGVADQGSL 980 LINPSHISLP 990 ESSFITPTAS 1000 LLQLPPALSG 1010 DGEWSGASSD 1020 SELLLPDTDG 1030 LRTLNMSSPV 1040 SVADFTYTTS 1050 VSGDDIKPLS 1060 KGEMMYGNET 1070 ELKMSSFSDM 1080 AYPSKSTVVP 1090 KMSDIVNKWS 1100 ESLKETSVSV 1110 SSINSVFTES 1120 LVYPITKVFD 1130 QEISRVPEII 1140 FPVKPTHTAS 1150 QASGDTWLKP 1160 GLSTNSEPAL 1170 SDTASSEVLH 1180 PSTQPLLYEA 1190 ASPFNTEALL 1200 QPSFPASDVD 1210 TLLKTALPSG 1220 PRDPVLTETP 1230 MVEQSSSSMS 1240 LPLASESASS 1250 KSTLHFTSVP 1260 VLNMSPSDVH 1270 PTSLQRLTVP 1280 HSREEYFEQG 1290 LLKSKSPQQV 1300 LPSLHSHDEF 1310 FQTAHLDISQ 1320 AYPPKGRHAF 1330 ATPILSIDEP 1340 QNTLISRLVY 1350 SEDIFMHPEI 1360 SITDKALTGL 1370 PTTVSDVLIA 1380 TDHSVPLGSG 1390 PISMTTVSPN 1400 RDDSVTTTKL 1410 LLPSKATSKP 1420 THSARSDADL 1430 VGGGEDGDDY 1440 DDDDYDDIDS 1450 DRFPVNKCMS 1460 CSPYRESQEK 1470 VMNDSDTQES 1480 SLVDQSDPIS 1490 HLLSENTEEE 1500 NGGTGVTRVD 1510 KSPDKSPPPS 1520 MLPQKHNDGR 1530 EDRDIQMGSA 1540 VLPHTPGSKA 1550 WAVLTSDEES 1560 GSGQGTSDSL 1570 NDNETSTDFS 1580 FPDVNEKDAD 1590 GVLEADDTGI 1600 APGSPRSSTP 1610 SVTSGHSGVS 1620 NSSEAEASNS 1630 SHESRIGLAE 1640 GLESEKKAVI 1650 PLVIVSALTF 1660 ICLVVLVGIL 1670 IYWRKCFQTA 1680 HFYLEDNTSP 1690 RVISTPPTPI 1700 FPISDDIGAI 1710 PIKHFPKHVA 1720 DLHASNGFTE 1730 EFETLKEFYQ 1740 EVQSCTVDLG 1750 ITADSSNHPD 1760 NKHKNRYVNI 1770 VAYDHSRVKL 1780 TQLAEKDGKL 1790 TDYINANYVD 1800 GYNRPKAYIA 1810 AQGPLKSTAE 1820 DFWRMIWEHN 1830 VEVIVMITNL 1840 VEKGRRKCDQ 1850 YWPTDGSEEY 1860 GSFLVNQKNV 1870 QVLAYYTVRN 1880 FTLRNTKIKK 1890 GSQKGRSSGR 1900 LVTQYHYTQW 1910 PDMGVPEYSL 1920 PVLAFVRKTA 1930 QAKRHAVGPV 1940 VVHCSAGVGR 1950 TGTYIVLDSM 1960 LQQIQHEGTV 1970 NIFGFLKHIR 1980 SQRNYLVQTE 1990 EQYVFIHDTL 2000 VEAILSKETE 2010 VPDSHIHSYV 2020 NTLLIPGPSG 2030 KTKLEKQFQL 2040 LSQSNILQSD 2050 YSTALKQCNR 2060 EKNRTSSIIP 2070 VERSRVGISS 2080 LSGEGTDYIN 2090 ASYIMGYYQS 2100 NEFIITQHPL 2110 LHTIKDFWRM 2120 IWDHNAQLVV 2130 MIPDGQNMAE 2140 DEFVYWPNKD 2150 EPINCESFKV 2160 TLMSEEHKCL 2170 SNEEKLIVQD 2180 FILEATQDDY 2190 VLEVRHFQCP 2200 KWPNPDSPIS 2210 KTFELISIIK 2220 EEAANRDGPM 2230 IVHDEHGGVT 2240 AGTFCALTTL 2250 MHQLEKENSM 2260 DVYQVAKMIN 2270 LMRPGVFTDI 2280 EQYQFLYKVV 2290 LSLVSTRQEE 2300 NPSTSLDSNG 2310 AALPDGNIAE SLESLV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0072534 perineuronal net
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045202 synapse
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0004725 protein tyrosine phosphatase activity
Biological Process GO:0007611 learning or memory
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0048709 oligodendrocyte differentiation
Biological Process GO:0031641 regulation of myelination
Biological Process GO:0070445 regulation of oligodendrocyte progenitor proliferation

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.