Search Results
Overview
| Uniprot ID | F1LNE4 |
|---|---|
| Protein Name | Glutamate receptor |
| Gene Name | Gria2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 349 | VEIERALKQVQVEGL |
| 462 | KHCGFKYKLTIVGDG |
| 759 | GYGIATPKGSSLRNA |
Function
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system
Protein Sequence
10
MQKIMHISVL
20
LSPVLWGLIF
30
GVSSNSIQIG
40
GLFPRGADQE
50
YSAFRVGMVQ
60
FSTSEFRLTP
70
HIDNLEVANS
80
FAVTNAFCSQ
90
FSRGVYAIFG
100
FYDKKSVNTI
110
TSFCGTLHVS
120
FITPSFPTDG
130
THPFVIQMRP
140
DLKGALLSLI
150
EYYQWDKFAY
160
LYDSDRGLST
170
LQAVLDSAAE
180
KKWQVTAINV
190
GNINNDKKDE
200
TYRSLFQDLE
210
LKKERRVILD
220
CERDKVNDIV
230
DQVITIGKHV
240
KGYHYIIANL
250
GFTDGDLLKI
260
QFGGANVSGF
270
QIVDYDDSLV
280
SKFIERWSTL
290
EEKEYPGAHT
300
ATIKYTSALT
310
YDAVQVMTEA
320
FRNLRKQRIE
330
ISRRGNAGDC
340
LANPAVPWGQ
350
GVEIERALKQ
360
VQVEGLSGNI
370
KFDQNGKRIN
380
YTINIMELKT
390
NGPRKIGYWS
400
EVDKMVVTLT
410
ELPSGNDTSG
420
LENKTVVVTT
430
ILESPYVMMK
440
KNHEMLEGNE
450
RYEGYCVDLA
460
AEIAKHCGFK
470
YKLTIVGDGK
480
YGARDADTKI
490
WNGMVGELVY
500
GKADIAIAPL
510
TITLVREEVI
520
DFSKPFMSLG
530
ISIMIKKPQK
540
SKPGVFSFLD
550
PLAYEIWMCI
560
VFAYIGVSVV
570
LFLVSRFSPY
580
EWHTEEFEDG
590
RETQSSESTN
600
EFGIFNSLWF
610
SLGAFMQQGC
620
DISPRSLSGR
630
IVGGVWWFFT
640
LIIISSYTAN
650
LAAFLTVERM
660
VSPIESAEDL
670
SKQTEIAYGT
680
LDSGSTKEFF
690
RRSKIAVFDK
700
MWTYMRSAEP
710
SVFVRTTAEG
720
VARVRKSKGK
730
YAYLLESTMN
740
EYIEQRKPCD
750
TMKVGGNLDS
760
KGYGIATPKG
770
SSLRNAVNLA
780
VLKLNEQGLL
790
DKLKNKWWYD
800
KGECGSGGGD
810
SKEKTSALSL
820
SNVAGVFYIL
830
VGGLGLAMLV
840
ALIEFCYKSR
850
AEAKRMKVAK
860
NPQNINPSSS
870
QNSQNFATYK
880
EGYNVYGIES
VKI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0032281 | AMPA glutamate receptor complex |
| Cellular Component | GO:0043198 | dendritic shaft |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0098839 | postsynaptic density membrane |
| Cellular Component | GO:0048787 | presynaptic active zone membrane |
| Molecular Function | GO:0004971 | AMPA glutamate receptor activity |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0022849 | glutamate-gated calcium ion channel activity |
| Biological Process | GO:0001919 | regulation of receptor recycling |
| Biological Process | GO:0060992 | response to fungicide |
| Biological Process | GO:0010226 | response to lithium ion |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.