Search Results
Overview
| Uniprot ID | F1LNF7 |
|---|---|
| Protein Name | Isocitrate dehydrogenase [NAD] subunit, mitochondrial |
| Gene Name | Idh3a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 134 | SMNLLLRKTFDLYAN |
| 195 | LITEGASKRIAEFAF |
| 232 | SDGLFLQKCREVAEN |
| 241 | REVAENCKDIKFNEM |
| 354 | AACFATIKDGKSLTK |
| 361 | KDGKSLTKDLGGNSK |
| 76 | MKIFDAAKAPIQWEE |
Function
Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers
Protein Sequence
10
TRMRPGVAAV
20
AAVREVDAMA
30
GSAWVSKVSR
40
LLGAFHNTKQ
50
VTRGFAGGVQ
60
TVTLIPGDGI
70
GPEISASVMK
80
IFDAAKAPIQ
90
WEERNVTAIQ
100
GPGGKWMIPP
110
EAKESMDKNK
120
MGLKGPLKTP
130
IAAGHPSMNL
140
LLRKTFDLYA
150
NVRPCVSIEG
160
YKTPYTDVNI
170
VTIRENTEGE
180
YSGIEHVIVD
190
GVVQSIKLIT
200
EGASKRIAEF
210
AFEYARNNHR
220
SNVTAVHKAN
230
IMRMSDGLFL
240
QKCREVAENC
250
KDIKFNEMYL
260
DTVCLNMVQD
270
PSQFDVLVMP
280
NLYGDILSDL
290
CAGLIGGLGV
300
TPSGNIGANG
310
VAIFESVHGT
320
APDIAGKDMA
330
NPTALLLSAV
340
MMLRHMGLFD
350
HAAKIEAACF
360
ATIKDGKSLT
370
KDLGGNSKCS
380
DFTEEICRRV
KDLD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0045242 | isocitrate dehydrogenase complex (NAD+) |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Molecular Function | GO:0004449 | isocitrate dehydrogenase (NAD+) activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0051287 | NAD binding |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.