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Overview

Uniprot ID	F1LNT0
Protein Name	Dihydropyrimidinase-related protein 4
Gene Name	Dpysl4
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
557	DFVYKRIKARNRLAE

Function

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration

Protein Sequence

10 MDVPPDSLQR 20 SSDTRNHRDP 30 KEPGRDDPAN 40 TTCPQSLPQN 50 GPSLQASAAP 60 RVSPPARPRP 70 RSPYRGHPAR 80 PWIRMSFQGK 90 KSIPRITSDR 100 LLIKGGKIVN 110 DDQSFHADLY 120 VEDGLIKQIG 130 ENLIVPGGIK 140 TIDAHGLMVL 150 PGGVDVHTRL 160 QMPVLGMTPA 170 DDFCQGTKAA 180 LAGGTTMILD 190 HVFPDAGVSL 200 LAAYEQWRER 210 ADSAACCDYS 220 LHVDIPRWHE 230 STKEELEALV 240 RDKGVNSFLV 250 FMAYKDRCQC 260 TDGQIYEIFS 270 LIRDLGAVAQ 280 VHAENGDIVE 290 EEQKRLLEQG 300 ITGPEGHVLS 310 HPEEVEAEAV 320 YRAVTIAKQA 330 NCPLYITKVM 340 SKGAADMVAQ 350 AKRRGVVVFG 360 EPITASLGTD 370 GSHYWSKNWA 380 KAAAFVTSPP 390 INPDPTTADH 400 LTSLLSSGDL 410 QVTGSAHCTF 420 TTAQKAVGKD 430 NFTLIPEGIN 440 GIEERMSVVW 450 EKCVASGKMD 460 ENEFVAVTST 470 NAAKIFNFYP 480 RKGRVAVGSD 490 ADLVIWNPRA 500 TKVISAKSHN 510 LNVEYNIFEG 520 VECRGMPTVV 530 ISQGRVVLED 540 GNLLVTPGAG 550 RFIPRKTFPD 560 FVYKRIKARN 570 RLAEIHGVPR 580 GLYDGPVHEV 590 MLPAKPGSGT 600 QARASCPGKI 610 SVPPVRNLHQ 620 SGFSLSGSQA 630 DDHIARRTAQ 640 KIMAPPGGRS NITSLS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0031005	filamin binding
Molecular Function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.