Search Results

Overview

Uniprot ID	F1LP30
Protein Name	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Gene Name	Mccc1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
262	MRIIRSEKEFQEQLE
277	SARREAKKSFNDDAM
736	PKDGRIKKVFFSEGA

Function

Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism

Protein Sequence

10 MIGSCGDAHL 20 LFGGRPTGNK 30 RLAQGGTLSR 40 VSQAVFGGQQ 50 GSAEMAAAAL 60 LAAVDRNQLR 70 RVPILLLQPR 80 EWPWKHRTVK 90 YGTTPGGSIT 100 KVLIANRGEI 110 ACRVIRTARK 120 MGVQSVAVYS 130 EADRNSMHVD 140 MADEAYSIGP 150 APSQQSYLAM 160 EKIIQVAKSS 170 AAQAIHPGYG 180 FLSENMEFAE 190 LCKQEGIIFI 200 GPPSTAIRDM 210 GIKSTSKSIM 220 AAAGVPVVEG 230 YHGNDQSDEC 240 LKEHAGKIGY 250 PVMIKAIRGG 260 GGKGMRIIRS 270 EKEFQEQLES 280 ARREAKKSFN 290 DDAMLIEKFV 300 DTPRHVEVQV 310 FGDHHGNAVY 320 LFERDCSVQR 330 RHQKIIEEAP 340 APGIDPEVRR 350 RLGEAAVRAA 360 KAVNYVGAGT 370 VEFIMDSKHN 380 FYFMEMNTRL 390 QVEHPVTEMI 400 TGTDLVEWQL 410 RIAAGEKIPL 420 SQEEIPLQGH 430 AFEARIYAED 440 PDNNFMPGAG 450 PLVHLSTPPP 460 DMSTRIETGV 470 RQGDEVSVHY 480 DPMIAKLVVW 490 ASDRQSALSK 500 LRYSLHQYNI 510 VGLRTNVDFL 520 LRLSGHSEFE 530 AGNVHTDFIP 540 QHHKDLLPTH 550 STIAKESVCQ 560 AALGLILKEK 570 EMTSAFKLHT 580 QDQFSPFSFS 590 SGRRLNISYT 600 RNMTLRSGKN 610 DIIIAVTYNR 620 DGSYDMQIEN 630 KLFRVLGDLS 640 NEDGYTYLKS 650 SVNGVASKSK 660 FILLDNTIYL 670 FSMEGSIEVG 680 IPVPKYLSPV 690 SAEGTQGGTI 700 APMTGTIEKV 710 FVKAGDRVKA 720 GDALMVMIAM 730 KMEHTIKAPK 740 DGRIKKVFFS 750 EGAQANRHAP LVEFEEEEV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004485	methylcrotonoyl-CoA carboxylase activity
Biological Process	GO:0019752	carboxylic acid metabolic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.