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Overview

Uniprot IDF1LP76
Protein NameElongator complex protein 1
Gene NameElp1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
166 ITVGWGSKDTQFHGS
472 AVGGTGFKVPLRTPH

Function

Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs

Protein Sequence

10 MRNLKLHQTL 20 EFRDIQAPGK 30 PQCFCLRAEQ 40 GTVLIGSERG 50 LTEVDPVKKE 60 VKTEISLVAE 70 GFLPEDGSGC 80 IVGIQDLLDQ 90 ESVCVATASG 100 DVIVCNVSTQ 110 QLECVGNVAS 120 GISVMSWSPD 130 QELLLLATAQ 140 QTLIMMTRDY 150 EVITEQQIHQ 160 DDFGEGKFIT 170 VGWGSKDTQF 180 HGSEGRPITF 190 PVQMHESALS 200 WDDHRPQITW 210 RGDGQFFAVS 220 VVCSQTGARK 230 IRVWNREFAL 240 QSTSESVPGL 250 GPSLAWKPSG 260 SLIASTQDKP 270 NQQDVVFFEK 280 NGLLHGYFTL 290 PFLKDEVKVN 300 DLLWNADSSV 310 LAVWLEDLPK 320 EGSSTLKSYV 330 QLWTVGNYHW 340 YLKQSLPFST 350 TGKNQIVSLL 360 WDPVTPGRLH 370 VLCQGWRYLC 380 CDWHWTTDRS 390 SGNSADDLAN 400 VAVIDGNKVL 410 VTVFQRTVTP 420 PPMCTYRLLI 430 PHPVNQVMFS 440 AHLGNDLAVL 450 DASNQISVYK 460 CDDKPDMDST 470 VKLGAVGGTG 480 FKVPLRTPHL 490 EKRYRIQFGN 500 KEEEEDVSPL 510 QFRFLTWIEG 520 DAFLAISHSH 530 SSPQSIIHHL 540 TMAGSEGDEE 550 QGQLNVSSSV 560 TVDGVVIGLC 570 CCSKTKSSAV 580 QLADGQVLKY 590 LWESPSSAVE 600 PWKNSEGRPV 610 RFARPCTQME 620 AAAIGGEECV 630 LGLTDRCRFF 640 INDTEVASNI 650 TSFAVCDDFL 660 LVTTHSHTCQ 670 CFSLSGASLK 680 MLQAGLCGSQ 690 VPSGEILRKV 700 ERGSRIVTVV 710 PQDTKLILQM 720 PRGNLEVVHH 730 RALVLAQIRK 740 WLDKLMFKEA 750 FECMRKLRIN 760 LNLIHDHNPK 770 VFLENVETFI 780 KQIDSVNHLN 790 LFFTELKEED 800 VTKTMYPPPV 810 TKSVQVSTNP 820 DGKKVDLICD 830 AMRVAMETIN 840 PRKFCLSILT 850 SHVKKTTPEL 860 DIVLQKVHEL 870 QGKIPFEPES 880 VSAEEALKYL 890 LLLVDVNELF 900 NHSLGTYDFD 910 LVLMVAEKSQ 920 KDPKEYLPFL 930 NTLKKMETNY 940 QRFTIDKYLK 950 RYEKALGHLS 960 KCGPEYFTEC 970 LNLIKDKNLY 980 KEALKLYRPD 990 SPQYQAVSVA 1000 YGEHLVQEHL 1010 YEPAGLVFAR 1020 CGAHEKALEA 1030 FLACGSWQQA 1040 LCMAAQLQMA 1050 KDKVAGLART 1060 LAGKLVEQRK 1070 HSEAATVLEQ 1080 YAQDYEEAVL 1090 LLLEGSAWEE 1100 ALRLVYKYDR 1110 VDIIETSVKP 1120 SILEAQKNYM 1130 DFLDSQTATF 1140 IRHKNRLKVV 1150 RELKSQAPRV 1160 HVDHEVAHGR 1170 ETDLFSETSS 1180 IRSGSEMSGR 1190 YSHSNSRISA 1200 RSSKNRRKAE 1210 RKKHSLKEGS 1220 PLEGLALLEA 1230 LSEVVQSIEK 1240 LKDEVHAILK 1250 VLFLFEFEEQ 1260 ARELQRAFES 1270 TLQLMGTALP 1280 DIWTLTGQQS 1290 SATPVLGPSS 1300 TVNSIMASYQ 1310 QQKTCVPVLD 1320 AWACLPPKID 1330 QRSQWKLSLL E

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0033588 elongator holoenzyme complex
Cellular Component GO:0005654 nucleoplasm
Biological Process GO:0002098 tRNA wobble uridine modification

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.