Search Results
Overview
| Uniprot ID | F1LP76 |
|---|---|
| Protein Name | Elongator complex protein 1 |
| Gene Name | Elp1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 166 | ITVGWGSKDTQFHGS |
| 472 | AVGGTGFKVPLRTPH |
Function
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs
Protein Sequence
10
MRNLKLHQTL
20
EFRDIQAPGK
30
PQCFCLRAEQ
40
GTVLIGSERG
50
LTEVDPVKKE
60
VKTEISLVAE
70
GFLPEDGSGC
80
IVGIQDLLDQ
90
ESVCVATASG
100
DVIVCNVSTQ
110
QLECVGNVAS
120
GISVMSWSPD
130
QELLLLATAQ
140
QTLIMMTRDY
150
EVITEQQIHQ
160
DDFGEGKFIT
170
VGWGSKDTQF
180
HGSEGRPITF
190
PVQMHESALS
200
WDDHRPQITW
210
RGDGQFFAVS
220
VVCSQTGARK
230
IRVWNREFAL
240
QSTSESVPGL
250
GPSLAWKPSG
260
SLIASTQDKP
270
NQQDVVFFEK
280
NGLLHGYFTL
290
PFLKDEVKVN
300
DLLWNADSSV
310
LAVWLEDLPK
320
EGSSTLKSYV
330
QLWTVGNYHW
340
YLKQSLPFST
350
TGKNQIVSLL
360
WDPVTPGRLH
370
VLCQGWRYLC
380
CDWHWTTDRS
390
SGNSADDLAN
400
VAVIDGNKVL
410
VTVFQRTVTP
420
PPMCTYRLLI
430
PHPVNQVMFS
440
AHLGNDLAVL
450
DASNQISVYK
460
CDDKPDMDST
470
VKLGAVGGTG
480
FKVPLRTPHL
490
EKRYRIQFGN
500
KEEEEDVSPL
510
QFRFLTWIEG
520
DAFLAISHSH
530
SSPQSIIHHL
540
TMAGSEGDEE
550
QGQLNVSSSV
560
TVDGVVIGLC
570
CCSKTKSSAV
580
QLADGQVLKY
590
LWESPSSAVE
600
PWKNSEGRPV
610
RFARPCTQME
620
AAAIGGEECV
630
LGLTDRCRFF
640
INDTEVASNI
650
TSFAVCDDFL
660
LVTTHSHTCQ
670
CFSLSGASLK
680
MLQAGLCGSQ
690
VPSGEILRKV
700
ERGSRIVTVV
710
PQDTKLILQM
720
PRGNLEVVHH
730
RALVLAQIRK
740
WLDKLMFKEA
750
FECMRKLRIN
760
LNLIHDHNPK
770
VFLENVETFI
780
KQIDSVNHLN
790
LFFTELKEED
800
VTKTMYPPPV
810
TKSVQVSTNP
820
DGKKVDLICD
830
AMRVAMETIN
840
PRKFCLSILT
850
SHVKKTTPEL
860
DIVLQKVHEL
870
QGKIPFEPES
880
VSAEEALKYL
890
LLLVDVNELF
900
NHSLGTYDFD
910
LVLMVAEKSQ
920
KDPKEYLPFL
930
NTLKKMETNY
940
QRFTIDKYLK
950
RYEKALGHLS
960
KCGPEYFTEC
970
LNLIKDKNLY
980
KEALKLYRPD
990
SPQYQAVSVA
1000
YGEHLVQEHL
1010
YEPAGLVFAR
1020
CGAHEKALEA
1030
FLACGSWQQA
1040
LCMAAQLQMA
1050
KDKVAGLART
1060
LAGKLVEQRK
1070
HSEAATVLEQ
1080
YAQDYEEAVL
1090
LLLEGSAWEE
1100
ALRLVYKYDR
1110
VDIIETSVKP
1120
SILEAQKNYM
1130
DFLDSQTATF
1140
IRHKNRLKVV
1150
RELKSQAPRV
1160
HVDHEVAHGR
1170
ETDLFSETSS
1180
IRSGSEMSGR
1190
YSHSNSRISA
1200
RSSKNRRKAE
1210
RKKHSLKEGS
1220
PLEGLALLEA
1230
LSEVVQSIEK
1240
LKDEVHAILK
1250
VLFLFEFEEQ
1260
ARELQRAFES
1270
TLQLMGTALP
1280
DIWTLTGQQS
1290
SATPVLGPSS
1300
TVNSIMASYQ
1310
QQKTCVPVLD
1320
AWACLPPKID
1330
QRSQWKLSLL
E
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0033588 | elongator holoenzyme complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Biological Process | GO:0002098 | tRNA wobble uridine modification |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.