Search Results
Overview
| Uniprot ID | F1LPB9 |
|---|---|
| Protein Name | Rabphilin-3A |
| Gene Name | Rph3a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 432 | HLLPGASKSNKLRTK |
| 590 | WLKPDMGKKAKHKTQ |
| 63 | RVIARAEKMEAMEQE |
| 656 | SAKGERLKHWYECLK |
Function
Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone
Protein Sequence
10
MTDTVVNRWM
20
YPGDGPLQSN
30
DKEQLQAGWS
40
VHPGAQTDRQ
50
RKQEELTDEE
60
KEIINRVIAR
70
AEKMEAMEQE
80
RIGRLVDRLE
90
TMRKNVAGDG
100
VNRCILCGEQ
110
LGMLGSACVV
120
CEDCKKNVCT
130
KCGVETSNNR
140
PHPVWLCKIC
150
LEQREVWKRS
160
GAWFFKGFPK
170
QVLPQPMPIK
180
KTKPQQPAGE
190
PATQEQPTPE
200
SRHPARAPAR
210
GDMEDRRAPG
220
QKPGPDLTSA
230
PGRGSHGPPT
240
RRASEARMST
250
TTRDSEGWDH
260
GHGGGAGDTS
270
RSPGGEQGLR
280
RANSVQASRP
290
APASMPSPAP
300
PQPVQPGPPG
310
GSRAAPGPGR
320
FPEQSTEAPP
330
SDPGYPGAVA
340
PAREERTGPT
350
GGFQAAPHTA
360
GPYSQAAPAR
370
QPPPAEEEEE
380
EANSYDSDEA
390
TTLGALEFSL
400
LYDQDNSNLQ
410
CTIIRAKGLK
420
PMDSNGLADP
430
YVKLHLLPGA
440
SKSNKLRTKT
450
LRNTRNPVWN
460
ETLQYHGITE
470
EDMQRKTLRI
480
SVCDEDKFGH
490
NEFIGETRFS
500
LKKLKANQRK
510
NFNICLERVI
520
PMKRAGTTGS
530
ARGMALYEEE
540
QVERIGDIEE
550
RGKILVSLMY
560
STQQGGLIVG
570
IIRCVHLAAM
580
DANGYSDPFV
590
KLWLKPDMGK
600
KAKHKTQIKK
610
KTLNPEFNEE
620
FFYDIKHSDL
630
AKKSLDISVW
640
DYDIGKSNDY
650
IGGCQLGISA
660
KGERLKHWYE
670
CLKNKDKKIE
680
RWHQLQNENH
VSSD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098850 | extrinsic component of synaptic vesicle membrane |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0016082 | synaptic vesicle priming |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.