Search Results

Overview

Uniprot ID	F1LPH1
Protein Name	Calpastatin
Gene Name	Cast
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
322	KSTGESSKAQSAGVT

Function

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue

Protein Sequence

10 MSRPGPKPAA 20 SSRPRRGAAA 30 SHTQEHVNEK 40 NIGSSSKPAE 50 KKGSDEKKAA 60 TLRSSQPPRP 70 HVGRAVTATN 80 VTASSAATGT 90 SPRMSTTGAK 100 AVKIESEKSQ 110 SSEPPVIHEK 120 KPKGKPKEGS 130 EPQTLPKHAS 140 DTGSKHAHKE 150 KALSRSNEQI 160 VSEKSSESKT 170 KFQDAPSADG 180 ESVAGGVTVA 190 TASDKVVVKK 200 KEKKSLTPTL 210 PMESTLNKLS 220 DKSGVNAALD 230 DLIDTLGECE 240 DTNKDDPPYT 250 GPVVLDPMDS 260 TYLEALGIKE 270 GTIPPEYRKL 280 LEKNEAITGP 290 LPDSPKPMGI 300 DHAIDALSSD 310 FTCSSPTGKQ 320 TEKEKSTGES 330 SKAQSAGVTR 340 SAVPPQEKKR 350 KVEEEVMNDQ 360 ALQALSDSLG 370 TRQPDPQSHL 380 RQAKQVKEAK 390 AKEERQEKCG 400 EDEDTVPAEY 410 RLKPAKDKDG 420 KPLLPEPEET 430 SKCLSESELI 440 GELSADFVQP 450 TYQEKPSMPA 460 AKKSKDTSQT 470 PMVEIVPFIS 480 MCSMPSAPPK 490 LAYSKGVVPD 500 DAVETLARSL 510 GTRKEDPEDE 520 KSLVDKVKEK 530 AKEEDHEKLG 540 EKEETIPPDY 550 RLEIVKDKDG 560 KPLLPKEAEE 570 QLPPLSDDFL 580 LDALSQDFSS 590 PANILSLGFE 600 DAKLSAAVSE 610 TVSQVPAPSN 620 HTAAPPPGTE 630 RRDKELDDAL 640 DELSDSLGQR 650 QPDPDENKPL 660 DDKVKEKIKA 670 EHSEKLGERD 680 DTIPPEYRHL 690 LDNDGKDKPE 700 KPLTKNTEKP 710 GQDQDPIDAL 720 SEDLDSCPPT 730 TETSQNTTKE 740 KGKKTSSSKA 750 SKNEEKTKDS 760 SKKTEEVPKP KVDEDATSL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity
Biological Process	GO:2000675	negative regulation of type B pancreatic cell apoptotic process
Biological Process	GO:1990709	presynaptic active zone organization

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.