Search Results

Overview

Uniprot ID	F1LQ48
Protein Name	Heterogeneous nuclear ribonucleoprotein L
Gene Name	Hnrnpl
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
527	STPEQAAKNRIQHPS
572	SVKVFSGKSERSSSG
62	GRAPKRLKTENAGDQ

Function

Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8

Protein Sequence

10 MSRRLLPRAE 20 KRRRRLEQRQ 30 QPDEQLRRAG 40 AMVKMAAAGG 50 GGGGGRYYGG 60 GNEGGRAPKR 70 LKTENAGDQH 80 GGGGGGGSGA 90 AGGGGGENYD 100 DPHKTPASPV 110 VHIRGLIDGV 120 VEADLVEALQ 130 EFGPISYVVV 140 MPKKRQALVE 150 FEDVLGACNA 160 VNYAADNQIY 170 IAGHPAFVNY 180 STSQKISRPG 190 DSDDSRSVNS 200 VLLFTILNPI 210 YSITTDVLYT 220 ICNPCGPVQR 230 IVIFRKNGVQ 240 AMVEFDSVQS 250 AQRAKASLNG 260 ADIYSGCCTL 270 KIEYAKPTRL 280 NVFKNDQDTW 290 DYTNPNLSGQ 300 GDPGSNPNKR 310 QRQPPLLGDH 320 PAEYGEGRGF 330 PSVDSRGSCA 340 PARRPPRKFS 350 PVLPLFPSHP 360 PGGPHGGYHS 370 HYHDEGYGPP 380 PPHYEGRRMG 390 PPVGGHRRGP 400 SRYGPQYGHP 410 PPPPPPPDYG 420 PHADSPVLMV 430 YGLDQSKMNC 440 DRVFNVFCLY 450 GNVEKVKFMK 460 SKPGAAMVEM 470 ADGYAVDRAI 480 THLNNNFMFG 490 QKMNVCVSKQ 500 PAIMPGQSYG 510 LEDGSCSYKD 520 FSESRNNRFS 530 TPEQAAKNRI 540 QHPSNVLHFF 550 NAPLEVTEEN 560 FFEICDELGV 570 KRPTSVKVFS 580 GKSERSSSGL 590 LEWDSKSDAL 600 ETLGFLNHYQ 610 MKNPNGPYPY 620 TLKLCFSTAQ HAS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030054	cell junction
Cellular Component	GO:0071944	cell periphery
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0045120	pronucleus
Cellular Component	GO:1990904	ribonucleoprotein complex
Cellular Component	GO:0035770	ribonucleoprotein granule
Cellular Component	GO:0001725	stress fiber
Cellular Component	GO:0045202	synapse
Molecular Function	GO:0031005	filamin binding
Molecular Function	GO:0003730	mRNA 3'-UTR binding
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:1990715	mRNA CDS binding
Molecular Function	GO:0097157	pre-mRNA intronic binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0000976	transcription cis-regulatory region binding
Biological Process	GO:0098609	cell-cell adhesion
Biological Process	GO:0034198	cellular response to amino acid starvation
Biological Process	GO:0007623	circadian rhythm
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0048025	negative regulation of mRNA splicing, via spliceosome
Biological Process	GO:0045727	positive regulation of translation
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
Biological Process	GO:0033623	regulation of integrin activation
Biological Process	GO:0043484	regulation of RNA splicing
Biological Process	GO:1901652	response to peptide

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.