Search Results

Overview

Uniprot ID	F1LQ66
Protein Name	PR domain zinc finger protein 2
Gene Name	Prdm2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
1613	SKAVIQSKTALASKR
479	VKELHPCKYCKKVFG

Function

S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene

Protein Sequence

10 MHQNTESVAA 20 TETLAEVPEH 30 VLRGLPEEVR 40 LFPSAVDKTR 50 IGVWATKPIL 60 KGKKFGPFVG 70 DKKKRSQVRN 80 NVYMWEVYYP 90 NLGWMCIDAT 100 DPEKGNWLRY 110 VNWACSGEEQ 120 NLFPLEINRA 130 IYYKTLKPIA 140 PGEELLVWYN 150 GEDNPEIAAA 160 IEEERASARS 170 KRSSPKSRRG 180 KKKSHENKNK 190 GIRTHPTQLK 200 ASELDSTFAN 210 MRGSAEGPKE 220 EDERPLASAP 230 EQPAPLPEVG 240 NQDAVPQVAI 250 PLPACEPQPE 260 VDGKQEVTDC 270 EVNDVEEEEL 280 EEEEELEEEE 290 EEELGEDGVE 300 EADMPNESSA 310 KEPEIRCEEK 320 PEDLLEEPQS 330 MSNEAREDSP 340 DVTPPPHTPR 350 AREEANGDVL 360 ETFMFPCQHC 370 ERKFATKQGL 380 ERHMHIHIST 390 INHAFKCKYC 400 GKRFGTQINR 410 RRHERRHETG 420 LKRRPSMTLQ 430 SSEDPDDGKG 440 ENVTSKDESS 450 PPQLGQDCLI 460 LNSEKTSQEV 470 LNSSFVEENG 480 EVKELHPCKY 490 CKKVFGTHTN 500 MRRHQRRVHE 510 RHLIPKGVRR 520 KGGLLEEPQP 530 PAEQAPPSQN 540 VYVPSTEPEE 550 EGETDDVYIM 560 DISSNISENL 570 NYYIDGKIQT 580 NSSTSNCDVI 590 EMESNSAHLY 600 GIDCLLTPVT 610 VEITQNIKST 620 QVSVTDDLLK 630 DSPSSTNCES 640 KKRRTASPPV 650 LPKIKTETES 660 DSTAPSCSLS 670 LPLSISTAEV 680 VSFHKEKGVY 690 LSSKLKQLLQ 700 TQDKLTLPAG 710 FSAAEIPKLG 720 PVCASAPASM 730 LPVTSSRFKR 740 RTSSPPSSPQ 750 HSPALRDFGK 760 PNDGKAAWTD 770 TVLTSKKPKL 780 ESRSDSPAWS 790 LSGRDERETG 800 SPPCFDEYKI 810 SKEWAASSTF 820 SSVCNQQPLD 830 LSSGVKQKSE 840 GTGKTPVPWE 850 SVLDLSVHKK 860 PCDSEGKEFK 870 ENHLAQPAAK 880 KKKPTTCMLQ 890 KVLLNEYNGV 900 SLPTETTPEV 910 TRSPSPCKSP 920 DTQPDPELGP 930 DSSCSVPTAE 940 SPPEVVGPSS 950 PPLQTASLSS 960 GQLPPLLTPT 970 EPSSPPPCPP 980 VLTVATPPPP 990 LLPTVPLSHP 1000 SSDASPQQCP 1010 SPFSNTTAQS 1020 PLPILSPTVS 1030 PSPSPIPPVE 1040 PLMSAASPGP 1050 PTLSSSSSSS 1060 SSFPSSSCSS 1070 TSPSPPPLSA 1080 VSSVVSSGDN 1090 LEASLPAVTF 1100 KQEESESEGL 1110 KPKEEAPPAG 1120 GQSVVQETFS 1130 KNFICNVCES 1140 PFLSIKDLTK 1150 HLSVHAEEWP 1160 FKCEFCVQLF 1170 KVKTDLSEHR 1180 FLLHGVGNIF 1190 VCSVCKKEFA 1200 FLCNLQQHQR 1210 DLHPDEVCTH 1220 HEFESGTLRP 1230 QNFTDPSKAN 1240 VEHMPSLPEE 1250 PLETSREEEL 1260 NDSSEELYTT 1270 IKIMASGIKT 1280 KDPDVRLGLN 1290 QHYPSFKPPP 1300 FQYHHRNPMG 1310 IGVTATNFTT 1320 HNIPQTFTTA 1330 IRCTKCGKGV 1340 DNMPELHKHI 1350 LACASASDKK 1360 RYTPKKNPVP 1370 LKQTVQPKNG 1380 VVVLDNSGKN 1390 AFRRMGQPKR 1400 LSFNVELGKM 1410 SPNKLKLSAL 1420 KKKNQLVQKA 1430 ILQKNRAAKQ 1440 KADLRDTSEA 1450 SSHICPYCDR 1460 EFTYIGSLNK 1470 HAAFSCPKKP 1480 LSPSKRKVSH 1490 SSKKGGHASS 1500 SSSDRNSSSH 1510 PRRRTADTEI 1520 KMQSTQAPLG 1530 KTRARSTGPA 1540 QASLPSSSFR 1550 SRQNVKFAAS 1560 VKSKKASSSS 1570 LRNSSPIRMA 1580 KITHVEGKKP 1590 KAVAKSHSAQ 1600 LSSKSSRGLH 1610 VRVQKSKAVI 1620 QSKTALASKR 1630 RTDRFIVKSR 1640 ERSGGPITRS 1650 LQLAAAADLS 1660 ESRREDSSAR 1670 HELKDFSYSL 1680 RLASRCGSST 1690 ASYITRQCRK 1700 VKAAAATPFQ GPFLKE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function	GO:0140949	histone H3K9 trimethyltransferase activity
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0032259	methylation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.