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Overview

Uniprot IDF1LQX4
Protein NameRho GTPase-activating protein 44
Gene NameArhgap44
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
175 SLQPAGAKADALREE
646 TLRKVSKKLAPIPPK

Function

GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:25498153). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (PubMed:25498153). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (PubMed:25498153). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity)

Protein Sequence

10 MKKQFNRMRQ 20 LANQTVGRAE 30 KTEVLSEDLL 40 QVEKRLELVK 50 QVSHSTHKKL 60 TACLQGQQGA 70 EADKRSKKLP 80 LTTLAQCLME 90 GSAILGDDTL 100 LGKMLKLCGE 110 TEDELAQELI 120 HFELRVERDV 130 IEPLFLLAEV 140 EIPNIQKQRK 150 HLAKLVLDMD 160 SSRTRWQQTS 170 KSSGLSSSLQ 180 PAGAKADALR 190 EEMEEAANRV 200 EICRDQLSAD 210 MYSFVAKEID 220 YANYFQTLIE 230 VQAEYHRKSL 240 TLLQAVLPQI 250 KAQQEAWVEK 260 PSFGKPLEEH 270 LMISGREIAF 280 PIEACVTMLL 290 ECGMQEEGLF 300 RVAPSASKLK 310 KLKAALDCCV 320 VDVQEYSADP 330 HAIAGALKSY 340 LRELPEPLMT 350 FELYDEWIQA 360 SNIQEQDKRL 370 QALWNACEKL 380 PKANHNNIRY 390 LIKFLSKLSE 400 YQDVNKMTPS 410 NMAIVLGPNL 420 LWPQSEGNIT 430 EMMTTVSLQI 440 VGIIEPIIQH 450 ADWFFPGEIE 460 FNITGSYGSP 470 VHVNHNANYS 480 SMPSPDMDPA 490 DRRQPEQARR 500 PLSVATDNMM 510 LEFYKKDGLR 520 KIQSMGVRVM 530 DTSWVARRGS 540 SAGRKAACAP 550 PSMQPPAPPS 560 ELAAPLPSPL 570 PEQVPDSPAT 580 PAPALSPSGA 590 SLQPTPERPS 600 VSKSKELSPG 610 SGQKGSPGSI 620 QGTTCPGTQL 630 GPQPAASPSQ 640 LPADQSPHTL 650 RKVSKKLAPI 660 PPKVPFVQPG 670 TVSDQPTGQP 680 SPVSLSPTPP 690 STPSPYGLSY 700 PPGYSMASGQ 710 LSPASAPPLA 720 SPSVFTSTLA 730 KSRPTPKPRQ 740 RPTLPPPQPP 750 SVSLSASSPQ 760 STEHPMLDGM 770 SPGESMSTDL 780 VHFDVPSIHI 790 ELGSTLRLSP 800 LEHARRHSVT 810 DKRDSEEESE STAL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030425 dendrite
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0031256 leading edge membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0098793 presynapse
Cellular Component GO:0048786 presynaptic active zone
Cellular Component GO:0055037 recycling endosome
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005543 phospholipid binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0006887 exocytosis
Biological Process GO:0099010 modification of postsynaptic structure
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0051490 negative regulation of filopodium assembly
Biological Process GO:0035021 negative regulation of Rac protein signal transduction
Biological Process GO:0032956 regulation of actin cytoskeleton organization
Biological Process GO:0061001 regulation of dendritic spine morphogenesis
Biological Process GO:0043087 regulation of GTPase activity
Biological Process GO:0099152 regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
Biological Process GO:0007165 signal transduction

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.