Search Results
Overview
| Uniprot ID | F1LRS8 |
|---|---|
| Protein Name | CD2-associated protein |
| Gene Name | Cd2ap |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | IQPHPQTKAMKKKTK |
| 221 | VGFGDIFKEGSVKLR |
| 365 | EKKTFPLKAEDRDEK |
| 397 | KKPTPPTKANNLLRS |
| 446 | TEPLSKPKLDPEQLP |
Function
Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (By similarity). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (PubMed:18753381). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. Plays a role in epithelial cell junctions formation (By similarity)
Protein Sequence
10
MVDYIVEYDY
20
DAVHDDELTI
30
RVGEIIRNVK
40
KLQEEGWLEG
50
ELNGRRGMFP
60
DNFVKEIKRE
70
TEPKDDNLPI
80
KRERPGNVAS
90
LVQRISTYGL
100
PAGGIQPHPQ
110
TKAMKKKTKK
120
RQCKVLFEYS
130
PQNEDELELT
140
VGDVIDVIEE
150
VEEGWWSGTL
160
NNKLGLFPSN
170
FVKELESTDD
180
GEMHDAQEES
190
EVSLTGPTSP
200
MPSPGNGSEP
210
APGSVTQPKK
220
IRGVGFGDIF
230
KEGSVKLRTR
240
TSSSETEEKK
250
SEKPLILQSL
260
GSRTQNVEVT
270
KPDIDGKIKA
280
KEYCKTVFPY
290
TGTNEDELTF
300
REGEIIHLIS
310
KETGEAGWWK
320
GELNGKEGVF
330
PDNFAVQISE
340
LDKDFPKPKK
350
PPPPAKGPAP
360
KPDPLAGEKK
370
TFPLKAEDRD
380
EKSLLEQKPS
390
KPAAPQVPPK
400
KPTPPTKANN
410
LLRSPGTMYP
420
KRPEKPVPPP
430
PPTAKINGEV
440
STISSKIDTE
450
PLSKPKLDPE
460
QLPVRPKSVD
470
LDALVARNSK
480
ETDNVNFDDI
490
ASSENLLHLT
500
ANRPKMPGRR
510
LPGRFNGGHS
520
PTQSPEKTLK
530
LPKDDDSGNI
540
KPSEFKKDAG
550
YSSKPSLSAP
560
SSASKVNTAA
570
FLSPLELKAK
580
VEADDGKKSS
590
LDELRAQIIE
600
LLCIVDALKK
610
DHGKELEKLR
620
RELEEEKAMR
630
SNLEVEIAKL
KKAVLLS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0072112 | podocyte differentiation |
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0031252 | cell leading edge |
| Cellular Component | GO:0071944 | cell periphery |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0030139 | endocytic vesicle |
| Cellular Component | GO:0031941 | filamentous actin |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0005770 | late endosome |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0005641 | nuclear envelope lumen |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0002102 | podosome |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0036057 | slit diaphragm |
| Cellular Component | GO:0032588 | trans-Golgi network membrane |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0030276 | clathrin binding |
| Molecular Function | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:0005172 | vascular endothelial growth factor receptor binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0030041 | actin filament polymerization |
| Biological Process | GO:0060612 | adipose tissue development |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0008283 | cell population proliferation |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0044331 | cell-cell adhesion mediated by cadherin |
| Biological Process | GO:0045216 | cell-cell junction organization |
| Biological Process | GO:0048668 | collateral sprouting |
| Biological Process | GO:0003158 | endothelium development |
| Biological Process | GO:0070371 | ERK1 and ERK2 cascade |
| Biological Process | GO:0046847 | filopodium assembly |
| Biological Process | GO:0010467 | gene expression |
| Biological Process | GO:0032835 | glomerulus development |
| Biological Process | GO:0001771 | immunological synapse formation |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0001822 | kidney development |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0051674 | localization of cell |
| Biological Process | GO:0048535 | lymph node development |
| Biological Process | GO:0035633 | maintenance of blood-brain barrier |
| Biological Process | GO:0008584 | male gonad development |
| Biological Process | GO:0061024 | membrane organization |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0051058 | negative regulation of small GTPase mediated signal transduction |
| Biological Process | GO:0032911 | negative regulation of transforming growth factor beta1 production |
| Biological Process | GO:0038180 | nerve growth factor signaling pathway |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0038179 | neurotrophin signaling pathway |
| Biological Process | GO:0048011 | neurotrophin TRK receptor signaling pathway |
| Biological Process | GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:1900182 | positive regulation of protein localization to nucleus |
| Biological Process | GO:0050714 | positive regulation of protein secretion |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0030163 | protein catabolic process |
| Biological Process | GO:0051291 | protein heterooligomerization |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:0009306 | protein secretion |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0032482 | Rab protein signal transduction |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0048259 | regulation of receptor-mediated endocytosis |
| Biological Process | GO:0048167 | regulation of synaptic plasticity |
| Biological Process | GO:0097018 | renal albumin absorption |
| Biological Process | GO:1990790 | response to glial cell derived neurotrophic factor |
| Biological Process | GO:0032868 | response to insulin |
| Biological Process | GO:0006979 | response to oxidative stress |
| Biological Process | GO:0071559 | response to transforming growth factor beta |
| Biological Process | GO:0009615 | response to virus |
| Biological Process | GO:0009611 | response to wounding |
| Biological Process | GO:0051403 | stress-activated MAPK cascade |
| Biological Process | GO:0050808 | synapse organization |
| Biological Process | GO:0050852 | T cell receptor signaling pathway |
| Biological Process | GO:0016050 | vesicle organization |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.