Search Results
Overview
| Uniprot ID | F1LRV6 |
|---|---|
| Protein Name | GMP reductase |
| Gene Name | Gmpr |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 277 | SSDTAMKKHAGGVAE |
Function
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation
Protein Sequence
10
MPRIDADLKL
20
DFKDVLLRPK
30
RSSLKSRSEV
40
DLERTFTFRN
50
SKQTYSGIPV
60
IVANMDTVGT
70
FEMAVVMSQH
80
AMFTAIHKHY
90
SLDDWKHFAE
100
NHPECLQHVA
110
VSSGSGQNDL
120
EKMSLILEAV
130
PQVKFICLDV
140
ANGYSEHFVE
150
FVKLVRSKFP
160
EHTIMAGNVV
170
TGEMVEELIL
180
SGADIIKVGV
190
GPGSVCTTRT
200
KTGVGYPQLS
210
AVIECADSAH
220
GLKGHIISDG
230
GCTCPGDVAK
240
AFGAGADFVM
250
LGGMFSGHTE
260
CAGEVIERNG
270
QKLKLFYGMS
280
SDTAMKKHAG
290
GVAEYRASEG
300
KTVEVPYKGD
310
VENTILDILG
320
GLRSTCTYVG
330
AAKLKELSRR
340
ATFIRVTQQH
NTVFG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1902560 | GMP reductase complex |
| Molecular Function | GO:0003920 | GMP reductase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006144 | purine nucleobase metabolic process |
| Biological Process | GO:0006163 | purine nucleotide metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.