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Overview

Uniprot IDF1LRZ7
Protein NameNeurofilament heavy polypeptide
Gene NameNefh
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1046 DKAAKGDK*******
114 RFAGYIDKVRQLEAH
219 ARVELQKKAQALQEE
264 AEARDALKCDVTSAL
305 DRLSEAAKVNTDAMR
336 TTELEALKSTKESLE
375 DNELRNTKWEMAAQL
525 AKSPAEAKSPAEAKS
549 VKSPAEAKSPAEAKS
567 VKSPATVKSPGEAKS
699 AKSPAEAKPPAEAKS
705 AKPPAEAKSPAEAKS
711 AKSPAEAKSPAEAKS
729 AKSPAEAKSPVEVKS
741 VKSPEKAKSPVKEGA
909 EPLTEKPKDSPGEAK
98 AVAARSEKEQLQALN
980 APEKKDTKEEKTTES

Function

Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks

Protein Sequence

10 MMSFGGADAL 20 LGAPFAPLHG 30 GGSLHYALSR 40 KAGAGGTRSA 50 AGSSSGFHSW 60 ARTSVSSVSA 70 SPSRFRGAGA 80 ASSTDSLDTL 90 SNGPEGCVVA 100 AVAARSEKEQ 110 LQALNDRFAG 120 YIDKVRQLEA 130 HNRSLEGEAA 140 ALRQQQAGRA 150 AMGELYEREV 160 REMRGAVLRL 170 GAARGQLRLE 180 QEHLLEDIAH 190 VRQRLDEEAR 200 QREEAEAAAR 210 ALARFAQEAE 220 AARVELQKKA 230 QALQEECGYL 240 RRHHQEEVGE 250 LLGQIQGCGA 260 AQAQAQAEAR 270 DALKCDVTSA 280 LREIRAQLEG 290 HTVQSTLQSE 300 EWFRVRLDRL 310 SEAAKVNTDA 320 MRSAQEEITE 330 YRRQLQARTT 340 ELEALKSTKE 350 SLERQRSELE 360 DRHQVDMASY 370 QDAIQQLDNE 380 LRNTKWEMAA 390 QLREYQDLLN 400 VKMALDIEIA 410 AYRKLLEGEE 420 CRIGFGPSPF 430 SLTEGLPKIP 440 SMSTHIKVKS 450 EEKIKVVEKS 460 EKETVIVEEQ 470 TEEIQVTEEV 480 TEEEDKEAQG 490 EEEEEAEEGG 500 EEAATTSPPA 510 EEAASPEKET 520 KSPVKEEAKS 530 PAEAKSPAEA 540 KSPAEAKSPA 550 EVKSPAEAKS 560 PAEAKSPAEV 570 KSPATVKSPG 580 EAKSPAEAKS 590 PAEVKSPVEA 600 KSPAEAKSPA 610 SVKSPGEAKS 620 PAEAKSPAEV 630 KSPATVKSPV 640 EAKSPAEVKS 650 PVTVKSPAEA 660 KSPVEVKSPA 670 SVKSPSEAKS 680 PAGAKSPAEA 690 KSPVVAKSPA 700 EAKSPAEAKP 710 PAEAKSPAEA 720 KSPAEAKSPA 730 EAKSPAEAKS 740 PVEVKSPEKA 750 KSPVKEGAKS 760 LAEAKSPEKA 770 KSPVKEEIKP 780 PAEVKSPEKA 790 KSPMKEEAKS 800 PEKAKTLDVK 810 SPEAKTPAKE 820 EAKRPADIRS 830 PEQVKSPAKE 840 EAKSPEKEET 850 RTEKVAPKKE 860 EVKSPVEEVK 870 AKEPPKKVEE 880 EKTPATPKTE 890 VKESKKDEAP 900 KEAQKPKAEE 910 KEPLTEKPKD 920 SPGEAKKEEA 930 KEKKAAAPEE 940 ETPAKLGVKE 950 EAKPKEKAED 960 AKAKEPSKPS 970 EKEKPKKEEV 980 PAAPEKKDTK 990 EEKTTESKKP 1000 EEKPKMEAKA 1010 KEEDKGLPQE 1020 PSKPKTEKAE 1030 KSSSTDQKDS 1040 QPSEKAPEDK AAKGDK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0097418 neurofibrillary tangle
Cellular Component GO:0005883 neurofilament
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0099160 postsynaptic intermediate filament cytoskeleton
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0099184 structural constituent of postsynaptic intermediate filament cytoskeleton
Biological Process GO:0061564 axon development
Biological Process GO:0033693 neurofilament bundle assembly
Biological Process GO:0099170 postsynaptic modulation of chemical synaptic transmission
Biological Process GO:1902513 regulation of organelle transport along microtubule

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.