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Overview

Uniprot IDF1LS86
Protein NameIsoleucine--tRNA ligase, cytoplasmic
Gene NameIars1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
606 QKMSKRKKNYPDPVS

Function

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA

Protein Sequence

10 MVQQVPENIS 20 FPAEEEKILQ 30 FWSKYNCFQE 40 CLKQSKLRPK 50 FTFYDGPPFA 60 TGLPHYGHIL 70 AGTIKDIVTR 80 YAHQSGFHVD 90 RRFGWDCHGL 100 PVEYEIDKTL 110 GIKGPEDVAK 120 MGIAEYNKQC 130 RAIVMRYSAE 140 WKSTVTRLGR 150 WIDFDNDYKT 160 LYPQFMESVW 170 WVFKQLYDKG 180 LVYRGVKVMP 190 FSTACGTPLS 200 NFESNQNYKD 210 VQDPSVFVTF 220 PLEEDENTSL 230 VAWTTTPWTL 240 PSNLALCVNP 250 EIQYVKIKDV 260 SRGKLFILME 270 ARLSALYKQE 280 SDYEILERFP 290 GASLKGKKYK 300 PLFDYFIKCK 310 ENGAFTVLVD 320 HYVKDEEGTG 330 VVHQAPYFGA 340 DDHRVCMDFN 350 IIQKDSAPVC 360 PVDASGCFTE 370 EVTHFVGQYV 380 KDADKNIIRM 390 LKEQGRLLVA 400 STFTHSYPFC 410 WRSDTPLIYK 420 SVPSWFVRVE 430 HMVDQLLKNN 440 DLCYWVPEFV 450 REKRFGNWLK 460 EARDWAISRN 470 RYWGTPIPLW 480 VSEDFEEVVC 490 IGSVAELEEL 500 SGTKISDLHR 510 ESIDHLTIPS 520 RCGKGPLRRV 530 SEVFDCWFES 540 GSMPYAQVHY 550 PFESKREFED 560 AFPADFIAEG 570 IDQTRGWFYT 580 LLVLATALFG 590 QPPFKNVIVN 600 GLILASDGQK 610 MSKRKKNYPD 620 PVSIINKYGA 630 DALRLYLINS 640 PVVRAENLRF 650 KEEGVRDVLK 660 DVLLPWYNAY 670 RFFIQNVFRL 680 HKEEEVEFLY 690 NEHTVRESPN 700 ITDRWILSFM 710 QSLIAFFETE 720 MAAYRLYTVV 730 PRLVKFVDIL 740 TNWYVRMNRR 750 RLKGENGMED 760 CVMALETLFS 770 VLLSLCRLMA 780 PYTPFLTELM 790 YQNLKLLIDP 800 ASIRDKDTLS 810 IHYLMLPHVR 820 EELIDKKTEN 830 AVSRMQSVIE 840 LGRVIRDRKT 850 IPIKYPLKEI 860 VVIHQDPEAL 870 EDIKSLEKYI 880 IEELNVRKVT 890 LSTDKNKYGI 900 RLRAEPDHMV 910 LGKRLKGAFK 920 AVMVAVKQLS 930 NEELEQFQKS 940 GSIVVEGHEL 950 HEEDIRLMYT 960 FDQATGGTAQ 970 FEAHSDAQAL 980 VLLDVTPDQS 990 MVDEGMAREV 1000 INRIQKLRKK 1010 CNLVPTDEIT 1020 VYYNAKSEGR 1030 YLSNVIESHT 1040 DFIYATIKAP 1050 LKPYPVPTSD 1060 NILIQEQTQL 1070 KGYELEITIT 1080 RGSCVPGPAC 1090 AYVNLNICAN 1100 GTEQGGVLLL 1110 ENPKGDNQLN 1120 LEKLKSVITS 1130 IFGVKSTGLS 1140 VFNGGTELQN 1150 QTDLLSLSGR 1160 TLCVTAGASL 1170 APASSPSTLL 1180 CQYINLQLVN 1190 AEPQECLTGT 1200 VGTLLLENPL 1210 GQNGLTHQGL 1220 VYEAAKVFGL 1230 RSRRLKLFLN 1240 ETQTQEITED 1250 IPMKTLNMKT 1260 VYVSVLPTTA DG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Molecular Function GO:0002161 aminoacyl-tRNA deacylase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0051020 GTPase binding
Molecular Function GO:0004822 isoleucine-tRNA ligase activity
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0006428 isoleucyl-tRNA aminoacylation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.