Search Results
Overview
| Uniprot ID | F1LS86 |
|---|---|
| Protein Name | Isoleucine--tRNA ligase, cytoplasmic |
| Gene Name | Iars1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 606 | QKMSKRKKNYPDPVS |
Function
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA
Protein Sequence
10
MVQQVPENIS
20
FPAEEEKILQ
30
FWSKYNCFQE
40
CLKQSKLRPK
50
FTFYDGPPFA
60
TGLPHYGHIL
70
AGTIKDIVTR
80
YAHQSGFHVD
90
RRFGWDCHGL
100
PVEYEIDKTL
110
GIKGPEDVAK
120
MGIAEYNKQC
130
RAIVMRYSAE
140
WKSTVTRLGR
150
WIDFDNDYKT
160
LYPQFMESVW
170
WVFKQLYDKG
180
LVYRGVKVMP
190
FSTACGTPLS
200
NFESNQNYKD
210
VQDPSVFVTF
220
PLEEDENTSL
230
VAWTTTPWTL
240
PSNLALCVNP
250
EIQYVKIKDV
260
SRGKLFILME
270
ARLSALYKQE
280
SDYEILERFP
290
GASLKGKKYK
300
PLFDYFIKCK
310
ENGAFTVLVD
320
HYVKDEEGTG
330
VVHQAPYFGA
340
DDHRVCMDFN
350
IIQKDSAPVC
360
PVDASGCFTE
370
EVTHFVGQYV
380
KDADKNIIRM
390
LKEQGRLLVA
400
STFTHSYPFC
410
WRSDTPLIYK
420
SVPSWFVRVE
430
HMVDQLLKNN
440
DLCYWVPEFV
450
REKRFGNWLK
460
EARDWAISRN
470
RYWGTPIPLW
480
VSEDFEEVVC
490
IGSVAELEEL
500
SGTKISDLHR
510
ESIDHLTIPS
520
RCGKGPLRRV
530
SEVFDCWFES
540
GSMPYAQVHY
550
PFESKREFED
560
AFPADFIAEG
570
IDQTRGWFYT
580
LLVLATALFG
590
QPPFKNVIVN
600
GLILASDGQK
610
MSKRKKNYPD
620
PVSIINKYGA
630
DALRLYLINS
640
PVVRAENLRF
650
KEEGVRDVLK
660
DVLLPWYNAY
670
RFFIQNVFRL
680
HKEEEVEFLY
690
NEHTVRESPN
700
ITDRWILSFM
710
QSLIAFFETE
720
MAAYRLYTVV
730
PRLVKFVDIL
740
TNWYVRMNRR
750
RLKGENGMED
760
CVMALETLFS
770
VLLSLCRLMA
780
PYTPFLTELM
790
YQNLKLLIDP
800
ASIRDKDTLS
810
IHYLMLPHVR
820
EELIDKKTEN
830
AVSRMQSVIE
840
LGRVIRDRKT
850
IPIKYPLKEI
860
VVIHQDPEAL
870
EDIKSLEKYI
880
IEELNVRKVT
890
LSTDKNKYGI
900
RLRAEPDHMV
910
LGKRLKGAFK
920
AVMVAVKQLS
930
NEELEQFQKS
940
GSIVVEGHEL
950
HEEDIRLMYT
960
FDQATGGTAQ
970
FEAHSDAQAL
980
VLLDVTPDQS
990
MVDEGMAREV
1000
INRIQKLRKK
1010
CNLVPTDEIT
1020
VYYNAKSEGR
1030
YLSNVIESHT
1040
DFIYATIKAP
1050
LKPYPVPTSD
1060
NILIQEQTQL
1070
KGYELEITIT
1080
RGSCVPGPAC
1090
AYVNLNICAN
1100
GTEQGGVLLL
1110
ENPKGDNQLN
1120
LEKLKSVITS
1130
IFGVKSTGLS
1140
VFNGGTELQN
1150
QTDLLSLSGR
1160
TLCVTAGASL
1170
APASSPSTLL
1180
CQYINLQLVN
1190
AEPQECLTGT
1200
VGTLLLENPL
1210
GQNGLTHQGL
1220
VYEAAKVFGL
1230
RSRRLKLFLN
1240
ETQTQEITED
1250
IPMKTLNMKT
1260
VYVSVLPTTA
DG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0002161 | aminoacyl-tRNA deacylase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0051020 | GTPase binding |
| Molecular Function | GO:0004822 | isoleucine-tRNA ligase activity |
| Molecular Function | GO:0000049 | tRNA binding |
| Biological Process | GO:0006428 | isoleucyl-tRNA aminoacylation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.