Search Results
Overview
| Uniprot ID | F1LSH0 |
|---|---|
| Protein Name | Symplekin |
| Gene Name | Sympk |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 358 | DDTESTLKKMKLEPN |
| 490 | KPESVLIKRRLSVQG |
Function
Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity
Protein Sequence
10
MASGSGDSVT
20
RRSVASQFFT
30
QEEGPGIDGM
40
TTSERVVDLL
50
NQAALITNDS
60
KITVLKQVQE
70
LIINKDPTLL
80
DNFLDEIIAF
90
QADKSTEVRK
100
FVIGFIEEAC
110
KRDIELLLKL
120
IANLNMLLRD
130
ENVNVVKKAI
140
LTMTQLYKVA
150
LQWMVKSRVI
160
SDLQEACWDM
170
VSSMAAEIIL
180
LLDSDNDGIR
190
THAIKFVEGL
200
IVTLSPRMAD
210
SEVPRRQEHD
220
ISLDRIPRDH
230
PYIQYNVLWE
240
EGKAALEQLL
250
KFMVHPAISS
260
INLTTALGSL
270
ANIARQRPMF
280
MSEVIQAYET
290
LHANLPPTLA
300
KSQVSSVRKN
310
LKLHLLSVLK
320
HPASLEFQAQ
330
ITTLLVDLGT
340
PQAEIARNMP
350
SSKDSRKRPR
360
DDTESTLKKM
370
KLEPNLGEDD
380
EDKDLEPGPS
390
GTSKASAQIS
400
GQSDTDITAE
410
FLQPLLTPDN
420
VANLVLISMV
430
YLPETMPASF
440
QAIYTPVESA
450
GTEAQIKHLA
460
RLMATQMTAA
470
GLGPGVEQTK
480
QCKEEPKEEK
490
VVKPESVLIK
500
RRLSVQGQAI
510
SVVGSQSTMS
520
PLEEEVPQAK
530
RRPEPIIPVT
540
QPRLAGAGGR
550
KKIFRLSDVL
560
KPLTDAQVEA
570
MKLGAVKRIL
580
RAEKAVACSG
590
AAQVRIKILA
600
SLVTQFDSGF
610
KAEVLSFILE
620
DVRARLDLAF
630
AWLYQEYNAY
640
LAAGPSGTLD
650
KYEDCLICLL
660
SGLQEKPDQK
670
DGIFTKVVLE
680
APLITESALE
690
VIRKYCEDES
700
RAYLGMSTLG
710
DLIFKRPSRQ
720
FQYLHVLLDL
730
SSHEKDRVRS
740
QALLFIKRMY
750
EKEQLREYVE
760
KFALNYLQLL
770
VHPNPPSVLF
780
GADKDTEVAA
790
PWTEETVKQC
800
LYLYLALLPQ
810
NHKLIHELAA
820
VYTEAIADIK
830
RTVLRVIEQP
840
IRGMGMNSPE
850
LLLLVENCPK
860
GAETLVTRCL
870
HSLTDKVPPS
880
PELVKRVRDL
890
YHKRLPDVRF
900
LIPVLNGLEK
910
KEVIQALPKL
920
IKLNPIVVKE
930
VFNRLLGTQH
940
GPCVVEVEKL
950
GEWGSHLMRD
960
IQAERGQATL
970
RLLTATNLCF
980
AERNVYTSEV
990
LAVVMQQLME
1000
QSPLPMLLMR
1010
TVIQSLTMYP
1020
RLGGFVMNIL
1030
ARLIMKQVWK
1040
YPKVWEGFIK
1050
CCQRTKPQSF
1060
QVILQLPPQQ
1070
LGAVFDKCPE
1080
LREPLLAHVR
1090
SFTPHQQAHI
1100
PNSIMTILEA
1110
SGKQEPEVKE
1120
APSGSLEEDD
1130
LEPLALALAP
1140
ALAPAPAPRP
1150
PQDLIGLRLA
1160
QEKALKRQLE
1170
EEQKQKPTGV
1180
GAPTSSVSST
1190
PLVGPAARAG
1200
PTPAEEVMEY
1210
REEGPECETP
1220
AIFISMDDDS
1230
GLAETTLLDS
1240
SLEGPLPKEA
1250
AAVGPSSKDE
1260
RSPQNLSHAV
1270
EEALKTSSPE
1280
AREPESKGNS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005923 | bicellular tight junction |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005886 | plasma membrane |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0006397 | mRNA processing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.