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Overview

Uniprot IDF1LSH0
Protein NameSymplekin
Gene NameSympk
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
358 DDTESTLKKMKLEPN
490 KPESVLIKRRLSVQG

Function

Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity

Protein Sequence

10 MASGSGDSVT 20 RRSVASQFFT 30 QEEGPGIDGM 40 TTSERVVDLL 50 NQAALITNDS 60 KITVLKQVQE 70 LIINKDPTLL 80 DNFLDEIIAF 90 QADKSTEVRK 100 FVIGFIEEAC 110 KRDIELLLKL 120 IANLNMLLRD 130 ENVNVVKKAI 140 LTMTQLYKVA 150 LQWMVKSRVI 160 SDLQEACWDM 170 VSSMAAEIIL 180 LLDSDNDGIR 190 THAIKFVEGL 200 IVTLSPRMAD 210 SEVPRRQEHD 220 ISLDRIPRDH 230 PYIQYNVLWE 240 EGKAALEQLL 250 KFMVHPAISS 260 INLTTALGSL 270 ANIARQRPMF 280 MSEVIQAYET 290 LHANLPPTLA 300 KSQVSSVRKN 310 LKLHLLSVLK 320 HPASLEFQAQ 330 ITTLLVDLGT 340 PQAEIARNMP 350 SSKDSRKRPR 360 DDTESTLKKM 370 KLEPNLGEDD 380 EDKDLEPGPS 390 GTSKASAQIS 400 GQSDTDITAE 410 FLQPLLTPDN 420 VANLVLISMV 430 YLPETMPASF 440 QAIYTPVESA 450 GTEAQIKHLA 460 RLMATQMTAA 470 GLGPGVEQTK 480 QCKEEPKEEK 490 VVKPESVLIK 500 RRLSVQGQAI 510 SVVGSQSTMS 520 PLEEEVPQAK 530 RRPEPIIPVT 540 QPRLAGAGGR 550 KKIFRLSDVL 560 KPLTDAQVEA 570 MKLGAVKRIL 580 RAEKAVACSG 590 AAQVRIKILA 600 SLVTQFDSGF 610 KAEVLSFILE 620 DVRARLDLAF 630 AWLYQEYNAY 640 LAAGPSGTLD 650 KYEDCLICLL 660 SGLQEKPDQK 670 DGIFTKVVLE 680 APLITESALE 690 VIRKYCEDES 700 RAYLGMSTLG 710 DLIFKRPSRQ 720 FQYLHVLLDL 730 SSHEKDRVRS 740 QALLFIKRMY 750 EKEQLREYVE 760 KFALNYLQLL 770 VHPNPPSVLF 780 GADKDTEVAA 790 PWTEETVKQC 800 LYLYLALLPQ 810 NHKLIHELAA 820 VYTEAIADIK 830 RTVLRVIEQP 840 IRGMGMNSPE 850 LLLLVENCPK 860 GAETLVTRCL 870 HSLTDKVPPS 880 PELVKRVRDL 890 YHKRLPDVRF 900 LIPVLNGLEK 910 KEVIQALPKL 920 IKLNPIVVKE 930 VFNRLLGTQH 940 GPCVVEVEKL 950 GEWGSHLMRD 960 IQAERGQATL 970 RLLTATNLCF 980 AERNVYTSEV 990 LAVVMQQLME 1000 QSPLPMLLMR 1010 TVIQSLTMYP 1020 RLGGFVMNIL 1030 ARLIMKQVWK 1040 YPKVWEGFIK 1050 CCQRTKPQSF 1060 QVILQLPPQQ 1070 LGAVFDKCPE 1080 LREPLLAHVR 1090 SFTPHQQAHI 1100 PNSIMTILEA 1110 SGKQEPEVKE 1120 APSGSLEEDD 1130 LEPLALALAP 1140 ALAPAPAPRP 1150 PQDLIGLRLA 1160 QEKALKRQLE 1170 EEQKQKPTGV 1180 GAPTSSVSST 1190 PLVGPAARAG 1200 PTPAEEVMEY 1210 REEGPECETP 1220 AIFISMDDDS 1230 GLAETTLLDS 1240 SLEGPLPKEA 1250 AAVGPSSKDE 1260 RSPQNLSHAV 1270 EEALKTSSPE 1280 AREPESKGNS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005886 plasma membrane
Biological Process GO:0007155 cell adhesion
Biological Process GO:0006397 mRNA processing

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.