Search Results
Overview
| Uniprot ID | F1LT35 |
|---|---|
| Protein Name | Large ribosomal subunit protein uL23 |
| Gene Name | Rpl23al1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 22 | HLKPKAKKEAPAPPK |
| 29 | KEAPAPPKAEAKAKA |
Function
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination
Protein Sequence
10
MLGIFQLWRL
20
KQDGHLKPKA
30
KKEAPAPPKA
40
EAKAKALKAK
50
KAVLKGVHSH
60
KKKKIRTSPT
70
FRRPKTLRLR
80
RQPKYPRKSA
90
PRRNKLDHYA
100
IIKFPLTTES
110
AMKKIEDNNT
120
LVFIVDVKAN
130
KHQIKQAVKK
140
LYDIDVAKVN
150
TLIRPDGEKK
160
AYVRLAPDYD
170
ALDVANKIGI
I
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0022625 | cytosolic large ribosomal subunit |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0019843 | rRNA binding |
| Molecular Function | GO:0003735 | structural constituent of ribosome |
| Biological Process | GO:0006412 | translation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.