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Overview

Uniprot ID	F1LWZ8
Protein Name	Inner nuclear membrane protein Man1
Gene Name	Lemd3
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
302	PFSALTAKSGGSRQE

Function

Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest

Protein Sequence

10 MAAAAATAAS 20 APQQLSDEEL 30 FSQLRRYGLS 40 PGPVTESTRP 50 VYLKKLKKLR 60 EEEQQQQQHR 70 AGGRGNKTRN 80 SNNNNTAAAA 90 SVAAAPAGMG 100 VRPGSGDFAY 110 LRTPAGLGRL 120 SASAPESPAG 130 GSGVAAAVPA 140 AGSKVLLGFS 150 SDESDVEASP 160 REQAGGGGAR 170 RDRAALQYRG 180 LKAPPAPPVA 190 GEATSGNSAE 200 RRKPHSWWGA 210 RRPVGPEPQL 220 PSGSDGAAED 230 VDEEVADGED 240 RDPEAEEPLW 250 GSRAVNGSRL 260 LPYSCREHYS 270 DSEEEDDGGD 280 VASARQVLKD 290 DSLSRHRPRR 300 SHSKPFSALT 310 AKSGGSRQET 320 SVQGGGGLAM 330 NDRAAAAGSL 340 DRSRNLEEAA 350 AEPGGGGGGG 360 GCDQVDSIPR 370 YRAGAKKLAP 380 LLSPPSPDVD 390 STLESPTGPL 400 KTNNHIGGGG 410 AFGVDSPSLY 420 ANSIPPGAAA 430 TAPGSLRINH 440 ANHTGSNHTY 450 LKNAYSKPKL 460 CEPEEELLQQ 470 FKREEVSPTG 480 SFSAHYLSMF 490 LLTAALNNTP 500 PPEKNLMMST 510 LYKLHDRLAQ 520 IAGDHECGRS 530 SQRMLSVQEA 540 AAYLKDLGPE 550 YEDVFNTSLL 560 WIFKNGKDVG 570 IRCVGYGPEE 580 DLTNITDVQF 590 LQSTRPQMPF 600 WCRFRRAFIT 610 VTHRLLLLCL 620 GVVLVCAVLR 630 YMRYRWTKEE 640 EETRQMYDMV 650 VKIIDVLRSH 660 NEACQETKDL 670 QPYMPIPHVR 680 DSLIQPQDRK 690 KMKKVWERAV 700 DFLAANESRV 710 RTETRRVGGA 720 DFVVWRWVQP 730 SASCDKTSVI 740 PSKVWQGQAF 750 HLDRRNSPPN 760 SLTPCLKIRN 770 MFDPVMEIGD 780 HWHLAIQEAI 790 LEKCSDNDGI 800 VHIAVDRNSR 810 EGCVYVKCLS 820 PGHAGKAFKA 830 LHGSWFDGKL 840 VTVKYLRLDR 850 YHHRFPQALT 860 CSTPLKPSDK 870 HMNSMSHLRL 880 RTGLANSQGS S

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005637	nuclear inner membrane
Molecular Function	GO:0003677	DNA binding

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.