Overview
| Uniprot ID | F1M0Z1 |
| Protein Name | Triple functional domain protein |
| Gene Name | Trio |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 1209 |
LADGFCEKGHAHAAE |
| 2158 |
RLQGFDGKIVAQGKL |
Function
Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth (By similarity). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (By similarity). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (PubMed:26721934). May act as a regulator of adipogenesis (By similarity)
Protein Sequence
10
MSGSSGGATA
20
PAASSGPAAA
30
ASAAGSGCGG
40
GAGEGAEEAA
50
KDLADIAAFF
60
RSGFRKNDEM
70
KAMDVLPILK
80
EKVAYLSGGR
90
DKRGGPILTF
100
PARSNHDRMR
110
QEDLRRLISY
120
LACIPSEEVC
130
KRGFTVIVDM
140
RGSKWDSIKP
150
LLKILQESFP
160
CCIHIALIIK
170
PDNFWQKQRT
180
NFGSSKFEFE
190
TNMVSLEGLT
200
KVVDPSQLTP
210
EFDGCLEYNH
220
EEWIEIRVAF
230
EDYISNAAHM
240
LSRLEELQDV
250
LAKKELPQDL
260
EGARNMIDEH
270
SQLKKKVIKA
280
PIEDLDLEGQ
290
KLLQRIQSSE
300
SFPKKNSGSG
310
NADLQNLLPK
320
VSTMLDRLHS
330
TRQHLHQMWH
340
VRKLKLDQCF
350
QLRLFEQDAE
360
KMFDWITHNK
370
GLFLNSYTEI
380
GASHPHAMEL
390
QTQHNHFAMN
400
CMNVYVNINR
410
IMSVANRLVE
420
SGHYASQQIK
430
QIANQLEQEW
440
KAFAAALDER
450
STLLDMSSIF
460
HQKAEKYMSN
470
VDSWCKACGE
480
VDLPSELQDL
490
EDAIHHHQGI
500
YEHITLAYSE
510
VSQDGKSLLD
520
KLQRPLTPGS
530
SDSLTASANY
540
SKAVHHVLDV
550
IHEVLHHQRQ
560
LENIWQHRKV
570
RLHQRLQLCV
580
FQQDVQQVLD
590
WIENHGEAFL
600
SKHTGVGKSL
610
HRARALQKRH
620
EDFEEVAQNT
630
YTNADKLLEA
640
AEQLAQTGEC
650
DPEEIYQAAH
660
QLEDRIQDFV
670
RRVEQRKILL
680
DMSVSFHTHV
690
KELWTWLEEL
700
QKELLDDVYA
710
ESVEAVQDLI
720
KRFGQQQQTT
730
LQVTVNVIKE
740
GEDLIQQLRD
750
SAISSNKTPH
760
NSSINHIETV
770
LQQLDEAQSQ
780
MEELFQERKI
790
KLELFLQLRI
800
FERDAIDIIS
810
DLESWNDELS
820
QQMNDFDTED
830
LTIAEQRLQH
840
HADKALTMNN
850
LTFDVIHQGQ
860
DLLQYVNEVQ
870
ASGVELLCDR
880
DVDMATRVQD
890
LLEFLHEKQQ
900
ELDLAAEQHR
910
KHLEQCVQLR
920
HLQAEVKQVL
930
GWIRNGESML
940
NAGLITASSL
950
QEAEQLQREH
960
EQFQHAIEKT
970
HQSALQVQQK
980
AEAMLQANHY
990
DMDMIRDCAE
1000
KVASHWQQLM
1010
LKMEDRLKLV
1020
NASVAFYKTS
1030
EQVCSVLESL
1040
EQEYKREEDW
1050
CGGADKLGPN
1060
SETDHVTPMI
1070
SKHLEQKEAF
1080
LKACTLARRN
1090
ADVFLKYLHR
1100
NSVSMPGMVT
1110
HIKAPEQQVK
1120
NILNELFQRE
1130
NRVLHYWTMR
1140
KRRLDQCQQY
1150
VVFERSAKQA
1160
LEWIHDNGEF
1170
YLSTHTSTGS
1180
SIQHTQELLK
1190
EHEEFQITAK
1200
QTKERVKLLI
1210
QLADGFCEKG
1220
HAHAAEIKKC
1230
VTAVDKRYRD
1240
FSLRMEKYRT
1250
SLEKALGISS
1260
DSNKSSKSLQ
1270
LDIIPASIPG
1280
SEVKLRDAAH
1290
ELNEEKRKSA
1300
RRKEFIMAEL
1310
IQTEKAYVRD
1320
LRECMDTYLW
1330
EMTSGVEEIP
1340
PGIVNKELII
1350
FGNMQEIYEF
1360
HNNIFLKELE
1370
KYEQLPEDVG
1380
HCFVTWADKF
1390
QMYVTYCKNK
1400
PDSTQLILEH
1410
AGSYFDEIQQ
1420
RHGLANSISS
1430
YLIKPVQRIT
1440
KYQLLLKELL
1450
TCCEEGKGEI
1460
KDGLEVMLSV
1470
PKRANDAMHL
1480
SMLEGFDENI
1490
ESQGELILQE
1500
SFQVWDPKTL
1510
IRKGRERHLF
1520
LFEMSLVFSK
1530
EVKDSSGRSK
1540
YLYKSKLFTS
1550
ELGVTEHVEG
1560
DPCKFALWVG
1570
RTPTSDNKIV
1580
LKASSIENKQ
1590
DWIKHIREVI
1600
QERTVHLRGA
1610
LKEPIHIPKT
1620
APAARQKGRR
1630
DGEDLDSQGD
1640
GSSQPDTISI
1650
ASRTSQNTLD
1660
SDKLSGGCEL
1670
TVVIHDFTAC
1680
NSNELTIRRG
1690
QTVEVLERPH
1700
DKPDWCLVRT
1710
TDRSPAAEGL
1720
VPCGSLCIAH
1730
SRSSMEMEGI
1740
FNHKDSLSVS
1750
SNDASPPASV
1760
ASLQPHMMGA
1770
QSSPGPKRPG
1780
NTLRKWLTSP
1790
VRRLSSGKAD
1800
GHAKKLAHKH
1810
KKSREVRKSA
1820
DAGSQKDSDD
1830
SAATPQDETI
1840
EERGRNEGLS
1850
SGTLSKSSSS
1860
GMQSCGEEEG
1870
EEGADAVPLP
1880
PPMAIQQHSL
1890
LQPDSQDDKA
1900
SSRLLVRPTS
1910
SETPSAAELV
1920
SAIEELVKSK
1930
MALEDRPSSL
1940
LVDQGDSSSP
1950
SFNPSDNSLL
1960
SSSSPIDEME
1970
ERKCSLSLKR
1980
RHYVLQELVE
1990
TERDYVRDLG
2000
CVVEGYMALM
2010
KEDGVPDDMK
2020
GKDKIVFGNI
2030
HQIYDWHRDF
2040
FLGELEKCLE
2050
DPEKLGSLFV
2060
KHERRLHMYI
2070
VYCQNKPKSE
2080
HIVSEYIDTF
2090
FEDLKQRLGH
2100
RLQLTDLLIK
2110
PVQRIMKYQL
2120
LLKDFLKYSK
2130
KASLDTSELE
2140
KAVEVMCIVP
2150
KRCNDMMNVG
2160
RLQGFDGKIV
2170
AQGKLLLQDT
2180
FLVTDQDAGL
2190
LPRCKERRVF
2200
LFEQIVIFSE
2210
PLDKKKGFSM
2220
PGFLFKNSIK
2230
VSCLCLEENV
2240
ESDPCKFALT
2250
SRTGDAVETF
2260
ILHSSSPSVR
2270
QTWIHEINQI
2280
LENQRNFLNA
2290
LTSPIEYQRN
2300
HSGGGGSGSG
2310
GSSGGGGGSG
2320
GSGASSGGSS
2330
SHGSGPSSCS
2340
SGPSSSRSRP
2350
SRIPQPVRHH
2360
PPMLVSSAAS
2370
SQAEADKMSG
2380
MSAPSPSLPT
2390
PSNSLALEAS
2400
LGQPSRLPLS
2410
GDSEGHERET
2420
EPIPKMKVME
2430
SPRKALGSTS
2440
GTSQDGNTKD
2450
ARGNLGPLPL
2460
GKTRPGAVSP
2470
LNSPLSTTFP
2480
SPFGKEAFPP
2490
SSPLQKGGSF
2500
WSSIPASPAS
2510
RPSSFTFPGD
2520
SDSLQRQTHR
2530
HAAPSKDTDR
2540
MSTCSSASEQ
2550
SVQSTQSNGS
2560
ESSSSSNIST
2570
MLVTHEYTAV
2580
KEDEINVYQG
2590
EVVQILASNQ
2600
QNMFLVFRAA
2610
TDQCPAAEGW
2620
IPGFVLGHTS
2630
AVIMENPDGT
2640
FKKSTSWHTA
2650
LRLRKKSEKK
2660
DKDGKRDGKL
2670
ENGYRKPREG
2680
LSNKLLNPNY
2690
IYDVPPEFVI
2700
PLSEVTCETG
2710
ETVVFRCRVC
2720
GRPKASITWK
2730
GPEHNTLNND
2740
DHYNISYSDV
2750
GEATLKIIGV
2760
STEDDGVYTC
2770
IAVNDMGSAS
2780
SSASLRVLGP
2790
GSDGIVVTWK
2800
DNFDAFYSEV
2810
AELGRGRFAV
2820
VKKCDQKGTK
2830
RAVATKFVNK
2840
KLMKRDQVTH
2850
ELGILQNLQH
2860
PLFVSLLDTF
2870
ETPTSYVLVL
2880
ELADQGRLLD
2890
CVVRWGSLTE
2900
GKVRAHLGEV
2910
LEAVRYLHNC
2920
RIAHLDLKPE
2930
NILVDQSLAK
2940
PTIKLTDFGD
2950
AVQLNTTYYI
2960
HQLLGNPEFA
2970
APEIILGNPV
2980
SLTADTWSVG
2990
VLTYVLLSGV
3000
SPFLDDSVEE
3010
TCLNICRLDF
3020
SFPEDYFQGV
3030
SQKAKEFVCF
3040
LLQEDPAKRP
3050
SAALALQEQW
3060
LQAGNGSGKG
3070
MGVLDTSRLT
3080
SFIERRKHQN
3090
DVRPIRSIKN
3100
FLQSRLLPRV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0042995 |
cell projection |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0019898 |
extrinsic component of membrane |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0098794 |
postsynapse |
| Cellular Component |
GO:0048786 |
presynaptic active zone |
| Cellular Component |
GO:0098685 |
Schaffer collateral - CA1 synapse |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Molecular Function |
GO:0004674 |
protein serine/threonine kinase activity |
| Biological Process |
GO:0007411 |
axon guidance |
| Biological Process |
GO:0050804 |
modulation of chemical synaptic transmission |
| Biological Process |
GO:0045599 |
negative regulation of fat cell differentiation |
| Biological Process |
GO:0048812 |
neuron projection morphogenesis |
| Biological Process |
GO:0099170 |
postsynaptic modulation of chemical synaptic transmission |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.