Search Results

Overview

Uniprot IDF1M0Z1
Protein NameTriple functional domain protein
Gene NameTrio
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1209 LADGFCEKGHAHAAE
2158 RLQGFDGKIVAQGKL

Function

Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth (By similarity). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (By similarity). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (PubMed:26721934). May act as a regulator of adipogenesis (By similarity)

Protein Sequence

10 MSGSSGGATA 20 PAASSGPAAA 30 ASAAGSGCGG 40 GAGEGAEEAA 50 KDLADIAAFF 60 RSGFRKNDEM 70 KAMDVLPILK 80 EKVAYLSGGR 90 DKRGGPILTF 100 PARSNHDRMR 110 QEDLRRLISY 120 LACIPSEEVC 130 KRGFTVIVDM 140 RGSKWDSIKP 150 LLKILQESFP 160 CCIHIALIIK 170 PDNFWQKQRT 180 NFGSSKFEFE 190 TNMVSLEGLT 200 KVVDPSQLTP 210 EFDGCLEYNH 220 EEWIEIRVAF 230 EDYISNAAHM 240 LSRLEELQDV 250 LAKKELPQDL 260 EGARNMIDEH 270 SQLKKKVIKA 280 PIEDLDLEGQ 290 KLLQRIQSSE 300 SFPKKNSGSG 310 NADLQNLLPK 320 VSTMLDRLHS 330 TRQHLHQMWH 340 VRKLKLDQCF 350 QLRLFEQDAE 360 KMFDWITHNK 370 GLFLNSYTEI 380 GASHPHAMEL 390 QTQHNHFAMN 400 CMNVYVNINR 410 IMSVANRLVE 420 SGHYASQQIK 430 QIANQLEQEW 440 KAFAAALDER 450 STLLDMSSIF 460 HQKAEKYMSN 470 VDSWCKACGE 480 VDLPSELQDL 490 EDAIHHHQGI 500 YEHITLAYSE 510 VSQDGKSLLD 520 KLQRPLTPGS 530 SDSLTASANY 540 SKAVHHVLDV 550 IHEVLHHQRQ 560 LENIWQHRKV 570 RLHQRLQLCV 580 FQQDVQQVLD 590 WIENHGEAFL 600 SKHTGVGKSL 610 HRARALQKRH 620 EDFEEVAQNT 630 YTNADKLLEA 640 AEQLAQTGEC 650 DPEEIYQAAH 660 QLEDRIQDFV 670 RRVEQRKILL 680 DMSVSFHTHV 690 KELWTWLEEL 700 QKELLDDVYA 710 ESVEAVQDLI 720 KRFGQQQQTT 730 LQVTVNVIKE 740 GEDLIQQLRD 750 SAISSNKTPH 760 NSSINHIETV 770 LQQLDEAQSQ 780 MEELFQERKI 790 KLELFLQLRI 800 FERDAIDIIS 810 DLESWNDELS 820 QQMNDFDTED 830 LTIAEQRLQH 840 HADKALTMNN 850 LTFDVIHQGQ 860 DLLQYVNEVQ 870 ASGVELLCDR 880 DVDMATRVQD 890 LLEFLHEKQQ 900 ELDLAAEQHR 910 KHLEQCVQLR 920 HLQAEVKQVL 930 GWIRNGESML 940 NAGLITASSL 950 QEAEQLQREH 960 EQFQHAIEKT 970 HQSALQVQQK 980 AEAMLQANHY 990 DMDMIRDCAE 1000 KVASHWQQLM 1010 LKMEDRLKLV 1020 NASVAFYKTS 1030 EQVCSVLESL 1040 EQEYKREEDW 1050 CGGADKLGPN 1060 SETDHVTPMI 1070 SKHLEQKEAF 1080 LKACTLARRN 1090 ADVFLKYLHR 1100 NSVSMPGMVT 1110 HIKAPEQQVK 1120 NILNELFQRE 1130 NRVLHYWTMR 1140 KRRLDQCQQY 1150 VVFERSAKQA 1160 LEWIHDNGEF 1170 YLSTHTSTGS 1180 SIQHTQELLK 1190 EHEEFQITAK 1200 QTKERVKLLI 1210 QLADGFCEKG 1220 HAHAAEIKKC 1230 VTAVDKRYRD 1240 FSLRMEKYRT 1250 SLEKALGISS 1260 DSNKSSKSLQ 1270 LDIIPASIPG 1280 SEVKLRDAAH 1290 ELNEEKRKSA 1300 RRKEFIMAEL 1310 IQTEKAYVRD 1320 LRECMDTYLW 1330 EMTSGVEEIP 1340 PGIVNKELII 1350 FGNMQEIYEF 1360 HNNIFLKELE 1370 KYEQLPEDVG 1380 HCFVTWADKF 1390 QMYVTYCKNK 1400 PDSTQLILEH 1410 AGSYFDEIQQ 1420 RHGLANSISS 1430 YLIKPVQRIT 1440 KYQLLLKELL 1450 TCCEEGKGEI 1460 KDGLEVMLSV 1470 PKRANDAMHL 1480 SMLEGFDENI 1490 ESQGELILQE 1500 SFQVWDPKTL 1510 IRKGRERHLF 1520 LFEMSLVFSK 1530 EVKDSSGRSK 1540 YLYKSKLFTS 1550 ELGVTEHVEG 1560 DPCKFALWVG 1570 RTPTSDNKIV 1580 LKASSIENKQ 1590 DWIKHIREVI 1600 QERTVHLRGA 1610 LKEPIHIPKT 1620 APAARQKGRR 1630 DGEDLDSQGD 1640 GSSQPDTISI 1650 ASRTSQNTLD 1660 SDKLSGGCEL 1670 TVVIHDFTAC 1680 NSNELTIRRG 1690 QTVEVLERPH 1700 DKPDWCLVRT 1710 TDRSPAAEGL 1720 VPCGSLCIAH 1730 SRSSMEMEGI 1740 FNHKDSLSVS 1750 SNDASPPASV 1760 ASLQPHMMGA 1770 QSSPGPKRPG 1780 NTLRKWLTSP 1790 VRRLSSGKAD 1800 GHAKKLAHKH 1810 KKSREVRKSA 1820 DAGSQKDSDD 1830 SAATPQDETI 1840 EERGRNEGLS 1850 SGTLSKSSSS 1860 GMQSCGEEEG 1870 EEGADAVPLP 1880 PPMAIQQHSL 1890 LQPDSQDDKA 1900 SSRLLVRPTS 1910 SETPSAAELV 1920 SAIEELVKSK 1930 MALEDRPSSL 1940 LVDQGDSSSP 1950 SFNPSDNSLL 1960 SSSSPIDEME 1970 ERKCSLSLKR 1980 RHYVLQELVE 1990 TERDYVRDLG 2000 CVVEGYMALM 2010 KEDGVPDDMK 2020 GKDKIVFGNI 2030 HQIYDWHRDF 2040 FLGELEKCLE 2050 DPEKLGSLFV 2060 KHERRLHMYI 2070 VYCQNKPKSE 2080 HIVSEYIDTF 2090 FEDLKQRLGH 2100 RLQLTDLLIK 2110 PVQRIMKYQL 2120 LLKDFLKYSK 2130 KASLDTSELE 2140 KAVEVMCIVP 2150 KRCNDMMNVG 2160 RLQGFDGKIV 2170 AQGKLLLQDT 2180 FLVTDQDAGL 2190 LPRCKERRVF 2200 LFEQIVIFSE 2210 PLDKKKGFSM 2220 PGFLFKNSIK 2230 VSCLCLEENV 2240 ESDPCKFALT 2250 SRTGDAVETF 2260 ILHSSSPSVR 2270 QTWIHEINQI 2280 LENQRNFLNA 2290 LTSPIEYQRN 2300 HSGGGGSGSG 2310 GSSGGGGGSG 2320 GSGASSGGSS 2330 SHGSGPSSCS 2340 SGPSSSRSRP 2350 SRIPQPVRHH 2360 PPMLVSSAAS 2370 SQAEADKMSG 2380 MSAPSPSLPT 2390 PSNSLALEAS 2400 LGQPSRLPLS 2410 GDSEGHERET 2420 EPIPKMKVME 2430 SPRKALGSTS 2440 GTSQDGNTKD 2450 ARGNLGPLPL 2460 GKTRPGAVSP 2470 LNSPLSTTFP 2480 SPFGKEAFPP 2490 SSPLQKGGSF 2500 WSSIPASPAS 2510 RPSSFTFPGD 2520 SDSLQRQTHR 2530 HAAPSKDTDR 2540 MSTCSSASEQ 2550 SVQSTQSNGS 2560 ESSSSSNIST 2570 MLVTHEYTAV 2580 KEDEINVYQG 2590 EVVQILASNQ 2600 QNMFLVFRAA 2610 TDQCPAAEGW 2620 IPGFVLGHTS 2630 AVIMENPDGT 2640 FKKSTSWHTA 2650 LRLRKKSEKK 2660 DKDGKRDGKL 2670 ENGYRKPREG 2680 LSNKLLNPNY 2690 IYDVPPEFVI 2700 PLSEVTCETG 2710 ETVVFRCRVC 2720 GRPKASITWK 2730 GPEHNTLNND 2740 DHYNISYSDV 2750 GEATLKIIGV 2760 STEDDGVYTC 2770 IAVNDMGSAS 2780 SSASLRVLGP 2790 GSDGIVVTWK 2800 DNFDAFYSEV 2810 AELGRGRFAV 2820 VKKCDQKGTK 2830 RAVATKFVNK 2840 KLMKRDQVTH 2850 ELGILQNLQH 2860 PLFVSLLDTF 2870 ETPTSYVLVL 2880 ELADQGRLLD 2890 CVVRWGSLTE 2900 GKVRAHLGEV 2910 LEAVRYLHNC 2920 RIAHLDLKPE 2930 NILVDQSLAK 2940 PTIKLTDFGD 2950 AVQLNTTYYI 2960 HQLLGNPEFA 2970 APEIILGNPV 2980 SLTADTWSVG 2990 VLTYVLLSGV 3000 SPFLDDSVEE 3010 TCLNICRLDF 3020 SFPEDYFQGV 3030 SQKAKEFVCF 3040 LLQEDPAKRP 3050 SAALALQEQW 3060 LQAGNGSGKG 3070 MGVLDTSRLT 3080 SFIERRKHQN 3090 DVRPIRSIKN 3100 FLQSRLLPRV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042995 cell projection
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0019898 extrinsic component of membrane
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0048786 presynaptic active zone
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0106310 protein serine kinase activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Biological Process GO:0007411 axon guidance
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0045599 negative regulation of fat cell differentiation
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0099170 postsynaptic modulation of chemical synaptic transmission

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.