Search Results

Overview

Uniprot ID	F1M3B3
Protein Name	PH-interacting protein
Gene Name	Phip
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
1469	AASSPERKKRILKPQ

Function

Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization

Protein Sequence

10 MSRERKGLSE 20 LRSELYFLIA 30 RFLEDGPCQQ 40 AAQVLIREVA 50 EKELLPRRTD 60 WTGKEHPRTY 70 QNLVKYYRHL 80 APDHLLQICH 90 RLGPLLEQEI 100 PQSVPGVQTL 110 LGAGRQSLLR 120 TNKSCKHVVW 130 KGSALAALHC 140 GRPPESPVNY 150 GSPPNIADTL 160 FSRKLNGKYR 170 LERLVPTAVY 180 QHMKMHKRIL 190 GHLSSVYCVT 200 FDRTGRRIFT 210 GSDDCLVKIW 220 ATDDGRLLAT 230 LRGHAAEISD 240 MAVNYENTMI 250 AAGSCDKMIR 260 VWCLRTCAPL 270 AVLQGHSASI 280 TSLQFSPLCS 290 GSKRYLSSTG 300 ADGTICFWLW 310 DAGTLKINPR 320 PTKFTERPRP 330 GVQMICSSFS 340 AGGMFLATGS 350 TDHIIRVYFF 360 GSGQPEKISE 370 LEFHTDKVDS 380 IQFSNTSNRF 390 VSGSRDGTAR 400 IWQFKRREWK 410 SILLDMATRP 420 AGQNLQGIED 430 KITKMKVTMV 440 AWDRHDSTVI 450 TAVNNMTLKV 460 WNSYTGQLIH 470 VLTGHEDEVF 480 VLEPHPFDPR 490 VLFSAGHDGN 500 VIVWDLARGV 510 KVRSYFNMIE 520 GQGHGAVFDC 530 KCSPDGQHFA 540 CTDSHGHLVI 550 FGFGSSSKYD 560 KIADQMFFHS 570 DYRPLIRDAN 580 NFVLDEQTQQ 590 APHLMPPPFL 600 VDVDGNPHPS 610 RYQRLVPGRE 620 NCREEQLIPQ 630 MGVTSSGLNQ 640 VLSQQAIQDI 650 SPLDSMIQRL 660 QQEQDLRRSG 670 EAAVSSAGRL 680 NRGSVSSTSE 690 VHSPPNVGLR 700 RSGQIEGVRQ 710 MHSNAPRSEI 720 ATERDLVAWS 730 RRVVVPELSA 740 GVASRQEEWR 750 TAKGEEEIKS 760 YRSEEKRKHL 770 TVAKENKILT 780 VSKNHAHEHF 790 LDLGDSKKQQ 800 ANQHNYRTRS 810 ALEETPRPLE 820 EIENGTSSSD 830 EGEVLAVSGG 840 TSEEEERAWH 850 SDGSSSDYSS 860 DYSDWTADAG 870 INLQPPKKVP 880 KHKTKKQDSS 890 SDEEEESENQ 900 KQKHIKKERK 910 KANEEKDGPT 920 SPKKKKPKER 930 KQKRLAVGEL 940 TENGLTLEEW 950 LPSAWITDTL 960 PRRCPFVPQM 970 GDEVYYFRQG 980 HEAYVEMARK 990 NRIYSINPKK 1000 QPWHKMELRE 1010 QELMKIVGIK 1020 YEVGLPTLCC 1030 LKLAFLDPDT 1040 GKLTGGSFTM 1050 KYHDMPDVID 1060 FLVLRQQFDD 1070 AKYRRWNIGD 1080 RFRSVIDDAW 1090 WFGTIESQEP 1100 LQPEYPDSLF 1110 QCYNVCWDNG 1120 DTEKMSPWDM 1130 ELIPNNAVFP 1140 EELGTSVPLT 1150 DVECRSLIYK 1160 PLDGEWGANP 1170 RDEECERIVG 1180 GINQLMTLDI 1190 ASAFVAPVDL 1200 QAYPMYCTVV 1210 AYPTDLSTIK 1220 QRLENRFYRR 1230 FSSLMWEVRY 1240 IEHNTRTFNE 1250 PGSPIVKSAK 1260 FVTDLLLHFI 1270 KHQHFLLFRD 1280 QTCYNIIPLY 1290 NSMKKKVLSD 1300 SEEEEKDADV 1310 PGTSTRKRKD 1320 HQPRRRLRNR 1330 AQSYDIQAWR 1340 KQCQELLNLI 1350 FQCEDSEPFR 1360 QPVDLLEYPD 1370 YRDIIDTPMD 1380 FATVRETLEA 1390 GNYESPMELC 1400 KDVRLIFSNS 1410 KAYTPSKRSR 1420 IYSMSLRLSA 1430 FFEEHISSVL 1440 SDYKSALRFH 1450 KRNTITKRRK 1460 RRNRSSSLSS 1470 SAASSPERKK 1480 RILKPQLKSE 1490 ISTSPFSIPT 1500 RSVLPRHSAA 1510 QMNGKPESSS 1520 VVRTRSNRIA 1530 VDPVVTEQPS 1540 TSAATKAFVS 1550 KTNTSAMPGK 1560 TILENSVKHS 1570 KALSTLSSPD 1580 QLTFSHGTKN 1590 NSAKENMEKE 1600 KPVKRKMKSS 1610 VFTKASPLPK 1620 SSAVVDQGDC 1630 KNNVLIPGTI 1640 QVNGHGGQPS 1650 KLVKRGPGRK 1660 PKVEVNTSSG 1670 EVTHKKRGRK 1680 PKNLQCTTKQ 1690 ENSEQNNMHP 1700 IRGDVVPSST 1710 CSFLSETNVV 1720 KEDLLQKKSR 1730 GGRKPKRKMK 1740 TQNLDSELIV 1750 PTNVKILRRS 1760 NRKKADDPID 1770 EEEEFEELKG 1780 SEPHMRTRNQ 1790 GRRTAFYNED 1800 DSEEEQRQLL 1810 FEDTSLTFGT 1820 SSRGRVRKLT 1830 EKAKANLIGW

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0140566	histone reader activity
Biological Process	GO:0007010	cytoskeleton organization
Biological Process	GO:0008286	insulin receptor signaling pathway
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
Biological Process	GO:0045840	positive regulation of mitotic nuclear division
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0006606	protein import into nucleus
Biological Process	GO:0008360	regulation of cell shape
Biological Process	GO:0040008	regulation of growth
Biological Process	GO:0001932	regulation of protein phosphorylation
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.