Search Results
Overview
| Uniprot ID | F1M3H8 |
|---|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein A0 |
| Gene Name | Hnrnpa0 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 133 | KAEIIADKQSGKKRG |
| 159 | ADKAAVVKFHPIQGH |
| 176 | EVKKAVPKEDIHAGG |
| 45 | VVVNPQTKRSRCFGF |
Function
mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs
Protein Sequence
10
MENSQLCKLF
20
IGGLNVQTSE
30
SGLRGHFEAF
40
GTLTDCVVVV
50
NPQTKRSRCF
60
GFVTYSNVEE
70
ADAAMAASPH
80
AVDGNTVELK
90
RAVSREDSAR
100
PGAHAKVKKL
110
FVGGLKGDVA
120
EGDLIEHFSQ
130
FGAVEKAEII
140
ADKQSGKKRG
150
FGFVYFQSHD
160
AADKAAVVKF
170
HPIQGHRVEV
180
KKAVPKEDIH
190
AGGGGARAAR
200
GGRGGGRGRG
210
GGGGGGGGRD
220
QNGLAKGGGG
230
GYNSYGGYGG
240
YGAYGGGGGG
250
GSYGGSDYGN
260
GFGGFGSYSQ
270
HQSSYGPMKS
280
GGGGGGGGGS
290
WGGRSNSGLG
300
PTHTFLCYSH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003729 | mRNA binding |
| Biological Process | GO:0070935 | 3'-UTR-mediated mRNA stabilization |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.