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Overview

Uniprot ID	F1M779
Protein Name	Clathrin heavy chain
Gene Name	Cltc
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
1063	EAFAIFRKFDVNTSA
1107	LAKAQLQKGMVKEAI
1111	QLQKGMVKEAIDSYI
1198	GDRCYDEKMYDAAKL
1243	ANSTRTWKEVCFACV
1253	CFACVDGKEFRLAQM
1336	WSRVNIPKVLRAAEQ
1490	SLAQRLEKHELIEFR
1505	RIAAYLFKGNNRWKQ
1524	CKKDSLYKDAMQYAS
1601	EYLTKVDKLDASESL
216	VRGQAGGKLHIIEVG
356	AEELFARKFNALFAQ
371	GNYSEAAKVAANAPK
378	KVAANAPKGILRTPD
445	EKWLKEDKLECSEEL
495	QKIVLYAKKVGYTPD
496	KIVLYAKKVGYTPDW
608	HIAQLCEKAGLLQRA
626	FTDLYDIKRAVVHTH
67	AIMNPASKVIALKAG
72	ASKVIALKAGKTLQI
726	KYIQAACKTGQIKEV
731	ACKTGQIKEVERICR
795	YIEIYVQKVNPSRLP
840	ELVAEVEKRNRLKLL
896	YDSRVVGKYCEKRDP

Function

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating

Protein Sequence

10 LAQLQNLGIN 20 PANIGFSTLT 30 MESDKFICIR 40 EKVGEQAQVV 50 IIDMNDPSNP 60 IRRPISADSA 70 IMNPASKVIA 80 LKAGKTLQIF 90 NIEMKSKMKA 100 HTMTDDVTFW 110 KWISLNTVAL 120 VTDNAVYHWS 130 MEGESQPVKM 140 FDRHSSLAGC 150 QIINYRTDAK 160 QKWLLLTGIS 170 AQQNRVVGAM 180 QLYSVDRKVS 190 QPIEGHAASF 200 AQFKMEGNAE 210 ESTLFCFAVR 220 GQAGGKLHII 230 EVGTPPTGNQ 240 PFPKKAVDVF 250 FPPEAQNDFP 260 VAMQISEKHD 270 VVFLITKYGY 280 IHLYDLETGT 290 CIYMNRISGE 300 TIFVTAPHEA 310 TAGIIGVNRK 320 GQVLSVCVEE 330 ENIIPYITNV 340 LQNPDLALRM 350 AVRNNLAGAE 360 ELFARKFNAL 370 FAQGNYSEAA 380 KVAANAPKGI 390 LRTPDTIRRF 400 QSVPAQPGQT 410 SPLLQYFGIL 420 LDQGQLNKYE 430 SLELCRPVLQ 440 QGRKQLLEKW 450 LKEDKLECSE 460 ELGDLVKSVD 470 PTLALSVYLR 480 ANVPNKVIQC 490 FAETGQVQKI 500 VLYAKKVGYT 510 PDWIFLLRNV 520 MRISPDQGQQ 530 FAQMLVQDEE 540 PLADITQIVD 550 VFMEYNLIQQ 560 CTAFLLDALK 570 NNRPSEGPLQ 580 TRLLEMNLMH 590 APQVADAILG 600 NQMFTHYDRA 610 HIAQLCEKAG 620 LLQRALEHFT 630 DLYDIKRAVV 640 HTHLLNPEWL 650 VNYFGSLSVE 660 DSLECLRAML 670 SANIRQNLQI 680 CVQVASKYHE 690 QLSTQSLIEL 700 FESFKSFEGL 710 FYFLGSIVNF 720 SQDPDVHFKY 730 IQAACKTGQI 740 KEVERICRES 750 NCYDPERVKN 760 FLKEAKLTDQ 770 LPLIIVCDRF 780 DFVHDLVLYL 790 YRNSLQKYIE 800 IYVQKVNPSR 810 LPVVIGGLLD 820 VDCSEDVIKN 830 LILVVRGQFS 840 TDELVAEVEK 850 RNRLKLLLPW 860 LEARIHEGCE 870 EPATHNALAK 880 IYIDSNNNPE 890 RFLRENPYYD 900 SRVVGKYCEK 910 RDPHLACVAY 920 ERGQCDLELI 930 NVCNENSLFK 940 SLSRYLVRRK 950 DPELWGSVLL 960 ESNPYRRPLI 970 DQVVQTALSE 980 TQDPEEVSVT 990 VKAFMTADLP 1000 NELIELLEKI 1010 VLDNSVFSEH 1020 RNLQNLLILT 1030 AIKADRTRVM 1040 EYINRLDNYD 1050 APDIANIAIS 1060 NELFEEAFAI 1070 FRKFDVNTSA 1080 VQVLIEHIGN 1090 LDRAYEFAER 1100 CNEPAVWSQL 1110 AKAQLQKGMV 1120 KEAIDSYIKA 1130 DDPSSYMEVV 1140 QAANTSGNWE 1150 ELVKYLQMAR 1160 KKARESYVET 1170 ELIFALAKTN 1180 RLAELEEFIN 1190 GPNNAHIQQV 1200 GDRCYDEKMY 1210 DAAKLLYNNV 1220 SNFGRLASTL 1230 VHLGEYQAAV 1240 DGARKANSTR 1250 TWKEVCFACV 1260 DGKEFRLAQM 1270 CGLHIVVHAD 1280 ELEELINYYQ 1290 DRGYFEELIT 1300 MLEAALGLER 1310 AHMGMFTELA 1320 ILYSKFKPQK 1330 MREHLELFWS 1340 RVNIPKVLRA 1350 AEQAHLWAEL 1360 VFLYDKYEEY 1370 DNAIITMMNH 1380 PTDAWKEGQF 1390 KDIITKVANV 1400 ELYYKAIQFY 1410 LEFKPLLLND 1420 LLMVLSPRLD 1430 HTRAVNYFSK 1440 VKQLPLVKPY 1450 LRSVQNHNNK 1460 SVNESLNNLF 1470 ITEEDYQALR 1480 TSIDAYDNFD 1490 NISLAQRLEK 1500 HELIEFRRIA 1510 AYLFKGNNRW 1520 KQSVELCKKD 1530 SLYKDAMQYA 1540 SESKDTELAE 1550 ELLQWFLQEE 1560 KRECFGACLF 1570 TCYDLLRPDV 1580 VLETAWRHNI 1590 MDFAMPYFIQ 1600 VMKEYLTKVD 1610 KLDASESLRK 1620 EEEQATETQP 1630 IVYGQPQLML 1640 TAGPSVAVPP 1650 QAPFGYGYTA 1660 PPYGQPQPGF GYSM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030132	clathrin coat of coated pit
Cellular Component	GO:0030130	clathrin coat of trans-Golgi network vesicle
Cellular Component	GO:0071439	clathrin complex
Molecular Function	GO:0032051	clathrin light chain binding
Molecular Function	GO:0005198	structural molecule activity
Biological Process	GO:0006914	autophagy
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:0016192	vesicle-mediated transport

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.