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Overview

Uniprot IDF1M801
Protein NameAnaphase-promoting complex subunit 1
Gene NameAnapc1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1346 GMHREKHKSPSYQIK

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins

Protein Sequence

10 MSNFSEERAT 20 MIAAGDLQEF 30 VPFGRDHCKH 40 HPNALNLQLR 50 QLQPASELWS 60 SDGAAGLVGS 70 LQEVTIHEKQ 80 KESWQLRKGV 90 SEIGDAADYD 100 EELYVAGNMV 110 IWSKGSKSQA 120 LAVYKAFTVD 130 STVQQALWCD 140 FIISQDKSEK 150 IYKSHELEKC 160 ICILQSSCMN 170 MHSIDGKDYI 180 ASLPFQVANV 190 WATKYGLLFE 200 RSSSSHEVPP 210 SLPREPLPTM 220 FSMLHPLDEI 230 TPLVCKSGSL 240 FGSSRVQYVV 250 DPAVKIVFLN 260 IDPSIVMTYD 270 AVQNVHSVWT 280 LRRVKPEEET 290 AVLKFPEQAG 300 TLQNAATSSS 310 LTAHLRSLSK 320 GESPVASPFQ 330 NYSSIHSQSR 340 SASSPSLHSR 350 SPSISNMAAL 360 SRAHSPALGV 370 HSFSGVQRFN 380 LSSHNQSPKR 390 HSISHSPSGS 400 FNDSFLAPET 410 EPIVPELCID 420 HLWTETLPNM 430 REKNSQASKV 440 FITTDLCGQK 450 FLCFLVEAQL 460 QLRCVKFQES 470 NDKTQLIFGS 480 VTNIHAKDAA 490 PVEKIDTMLV 500 LEGNGNLVLY 510 TGVVRVGKVF 520 IPGLPAPSLT 530 MSNMMPRPST 540 PLDGVSTPKP 550 LSKLLGSMDE 560 VVLLSPVPEL 570 RDSSKLNDSL 580 YNEDCTFQQL 590 GTYIHSVRDP 600 VHNRVTLELS 610 NGSMVRITIP 620 EVATSELVQT 630 CLQAIKFILP 640 KEVAVQVLVK 650 WYNVHSAPGG 660 PSCHSEWSLF 670 VICLLNMMGY 680 NTDRLAWTRS 690 FDFEGSLSPV 700 IAPKKARPSD 710 TGSDDDWEYL 720 LNSEYHHNVE 730 SHLLNKSLCL 740 NALEVTKTKD 750 EDFPQNLSLD 760 SSTLLFAHIP 770 AIFFVLHLVY 780 EELKLNTLMG 790 EGICSLIDLL 800 VQLARDLKLE 810 PYLDHYYRDY 820 PTLVKTTGQV 830 CTIDQGQMGF 840 MHHPSFFTSE 850 PPSIYQWVSS 860 CLKGEGTPPY 870 PYLPGICERS 880 RLVVLSIALY 890 TLGDESCVSD 900 ETSQYLSKVT 910 LTPQKPQAEQ 920 EENRFTFRQS 930 ASVSVLAERL 940 VVWMASVGFT 950 LRDLETLPFG 960 IALPIRDAIY 970 HCREQPDSDW 980 SEAVCLLIGR 990 QDLSKQACEG 1000 NLPRGKSVLS 1010 SDVASGAEAE 1020 EEDDGMNDLN 1030 HEVMSLIWSE 1040 DLRVQDVRRL 1050 LQSAQPVRVN 1060 VVQYPELSDH 1070 EFIEEKENRL 1080 LQLCQRTMAL 1090 PVGRGMFTLF 1100 SYHPVPTEPL 1110 PIPKLNLTGR 1120 APPRNTTVDL 1130 NSGNIDVPPN 1140 MASWASFHNG 1150 VAAGLKIAPA 1160 SQIDSAWIVY 1170 NKPKHAELAN 1180 EYAGFLMALG 1190 LNGHLTKLAT 1200 LNIHDYLTKG 1210 HEMTSIGLLL 1220 GVSAAKLGTM 1230 DMSITRLLSI 1240 HVPALLPPTS 1250 TELDVPHNVQ 1260 VAAVVGIGLV 1270 YQGTAHRHTA 1280 EVLLAEIGRP 1290 PGPEMEYCTD 1300 RESYSLAAGL 1310 ALGMVCLGHG 1320 SNLIGMSDLN 1330 VPEQLYQYMV 1340 GGHRRFQTGM 1350 HREKHKSPSY 1360 QIKEGDTINV 1370 DVTCPGATLA 1380 LAMIYLKTNN 1390 RSIADWLRAP 1400 DTMYLLDFVK 1410 PEFLLLRTLA 1420 RCLILWDDIL 1430 PNSKWVDSNV 1440 PQIIRENSIS 1450 LSEIELPCSE 1460 DLNLETLSQA 1470 HVYIIAGACL 1480 SLGFRFAGSE 1490 NLSAFNCLHK 1500 FAKDFMNYLS 1510 APNASVTGPY 1520 NLETCLSVVL 1530 LSLAMVMAGS 1540 GNLKVLQLCR 1550 FLHMKTGGEM 1560 NYGFHLAHHM 1570 ALGLLFLGGG 1580 RYSLSTSNSS 1590 IAALLCALYP 1600 HFPAHSTDNR 1610 YHLQALRHLY 1620 VLAAEPRLLV 1630 PVDVDTNTPC 1640 YALIEVTYKG 1650 TQWYEQTKEE 1660 LMAPTLLPEL 1670 HLLKQMKVKG 1680 PRYWELLIDL 1690 SKGEQHLRSI 1700 LSKDGVLYVK 1710 LRAGQLSYKE 1720 DPMGWQSLLA 1730 QTVANRNSEA 1740 RAFKPETISS 1750 FTSDPALLSF 1760 AEYFCKPTVS 1770 MGQKQEILDL 1780 FSSILYECVA 1790 QETPEMLPAY 1800 IAMDQALRSL 1810 KKRDMSNTSD 1820 LWQIKLILEF 1830 FSSRSHQERQ 1840 QTYPKRGLFI 1850 NSEFLPVVKC 1860 TVDSTLDQWL 1870 QAGGDVCVHA 1880 YLSGQPVEKS 1890 QLNMLACFLV 1900 YHSVPAPRHL 1910 PPLGLEGSTS 1920 FAELLFRFRH 1930 LKMPVRALLR 1940 LAPVLLGNPQ PMVM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005680 anaphase-promoting complex
Cellular Component GO:0005634 nucleus
Biological Process GO:0031145 anaphase-promoting complex-dependent catabolic process
Biological Process GO:0051301 cell division
Biological Process GO:0141198 protein branched polyubiquitination
Biological Process GO:0070979 protein K11-linked ubiquitination
Biological Process GO:0070936 protein K48-linked ubiquitination

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.