Search Results
Overview
| Uniprot ID | F1M8K0 |
|---|---|
| Protein Name | Dystroglycan 1 |
| Gene Name | Dag1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 879 | EGKGSRPKNMTPYRS |
Function
Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity
Protein Sequence
10
MSVDNWLLHP
20
LWGQTFLLLL
30
SVAVAQAHWP
40
SEPSEAVRDW
50
KNQLEASMHS
60
VLSDFQEAVP
70
TVVGIPDGTA
80
VVGRSFRVSI
90
PTDLIASSGE
100
IIKVSAAGKE
110
ALPSWLHWDP
120
HSHILEGLPL
130
DTDKGVHYIS
140
VSAARLGANG
150
SHVPQTASVF
160
SIEVYPEDHS
170
EPQSVRAASS
180
DPGEVVSSAC
190
AADEPVTVLT
200
VILDADLTKM
210
TPKQRIDLLN
220
RMQSFSEVEL
230
NNMKLVPVVN
240
NRLFDMSAFM
250
AGPGNAKKVV
260
ENGALLSWKL
270
GCSLNQNSVP
280
DIRGVETPAR
290
EGTMSAHLGY
300
PVVGWHIANK
310
KPTLPKRIRR
320
QIHATPTPVT
330
AIGPPTTAIQ
340
EPPSRIVPTP
350
TSPAIAPPTE
360
TMAPPVRDPV
370
PGKPTVTIRT
380
RGAIIQTPTL
390
GPIPPTRVSE
400
AGTTVPGQIR
410
PTLTIPGYVE
420
PTAVVTPPTT
430
TTKKPRVSTP
440
KPATPSTDSS
450
TTTTRRPTKK
460
PRTPRPVPRV
470
TTKAPITRLE
480
TASPPTRIRT
490
TTSAVPRGGE
500
ANQRPELKNH
510
IDRVDAWVGT
520
YFEVKIPSDT
530
FYDNEDTTTD
540
KLKLTLKLRE
550
QQLVGEKSWV
560
QFNSNSQLMY
570
GLPDSSHVGK
580
HEYFMHATDK
590
GGLSAVDAFE
600
IHVHKRPQGD
610
KAPARFKAKL
620
AGDPAPVVND
630
IHKKIALVKK
640
LAFAFGDRNC
650
SSITLQNITR
660
GSIVVEWTNN
670
TLPLEPCPKE
680
QIVGLSRRIA
690
DENGKPRPAF
700
SNALEPDFKA
710
LSVAVAGSGS
720
CRHLQFIPVA
730
PPSPGTSAAP
740
ATEVPDRDPE
750
KSSEDDVYLH
760
TVIPAVVVAA
770
ILLIAGIIAM
780
ICYRKKRKGK
790
LTLEDQATFI
800
KKGVPIIFAD
810
ELDDSKPPPS
820
SSMPLILQEE
830
KAPLPPPEYP
840
NQSVPETTPL
850
NQDTVGEYTP
860
LRDEDPNAPP
870
YQPPPPFTAP
880
MEGKGSRPKN
890
MTPYRSPPPY
VPP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016010 | dystrophin-associated glycoprotein complex |
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0070938 | contractile ring |
| Cellular Component | GO:0043034 | costamere |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0016011 | dystroglycan complex |
| Biological Process | GO:0014044 | Schwann cell development |
| Biological Process | GO:0014037 | Schwann cell differentiation |
| Biological Process | GO:0043403 | skeletal muscle tissue regeneration |
| Biological Process | GO:0007416 | synapse assembly |
| Biological Process | GO:0051124 | synaptic assembly at neuromuscular junction |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0060077 | inhibitory synapse |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0033268 | node of Ranvier |
| Cellular Component | GO:0034399 | nuclear periphery |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0098684 | photoreceptor ribbon synapse |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0044853 | plasma membrane raft |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0099524 | postsynaptic cytosol |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0042383 | sarcolemma |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051393 | alpha-actinin binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0002162 | dystroglycan binding |
| Molecular Function | GO:0043395 | heparan sulfate proteoglycan binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0043236 | laminin binding |
| Molecular Function | GO:0005055 | laminin receptor activity |
| Molecular Function | GO:0043237 | laminin-1 binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0004252 | serine-type endopeptidase activity |
| Molecular Function | GO:0042169 | SH2 domain binding |
| Molecular Function | GO:0038023 | signaling receptor activity |
| Molecular Function | GO:0008307 | structural constituent of muscle |
| Molecular Function | GO:0015631 | tubulin binding |
| Molecular Function | GO:0017166 | vinculin binding |
| Molecular Function | GO:0001618 | virus receptor activity |
| Biological Process | GO:0060055 | angiogenesis involved in wound healing |
| Biological Process | GO:0007411 | axon guidance |
| Biological Process | GO:0031103 | axon regeneration |
| Biological Process | GO:0071711 | basement membrane organization |
| Biological Process | GO:0060445 | branching involved in salivary gland morphogenesis |
| Biological Process | GO:0016340 | calcium-dependent cell-matrix adhesion |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0071397 | cellular response to cholesterol |
| Biological Process | GO:0071260 | cellular response to mechanical stimulus |
| Biological Process | GO:0071679 | commissural neuron axon guidance |
| Biological Process | GO:0060441 | epithelial tube branching involved in lung morphogenesis |
| Biological Process | GO:0085029 | extracellular matrix assembly |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0003007 | heart morphogenesis |
| Biological Process | GO:1904862 | inhibitory synapse assembly |
| Biological Process | GO:0006509 | membrane protein ectodomain proteolysis |
| Biological Process | GO:0034453 | microtubule anchoring |
| Biological Process | GO:0002011 | morphogenesis of an epithelial sheet |
| Biological Process | GO:0002009 | morphogenesis of an epithelium |
| Biological Process | GO:0016203 | muscle attachment |
| Biological Process | GO:0022011 | myelination in peripheral nervous system |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:0043409 | negative regulation of MAPK cascade |
| Biological Process | GO:0051898 | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0021675 | nerve development |
| Biological Process | GO:0021682 | nerve maturation |
| Biological Process | GO:0001954 | positive regulation of cell-matrix adhesion |
| Biological Process | GO:0031643 | positive regulation of myelination |
| Biological Process | GO:0048714 | positive regulation of oligodendrocyte differentiation |
| Biological Process | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0045860 | positive regulation of protein kinase activity |
| Biological Process | GO:0035022 | positive regulation of Rac protein signal transduction |
| Biological Process | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering |
| Biological Process | GO:0035418 | protein localization to synapse |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0098696 | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane |
| Biological Process | GO:0050807 | regulation of synapse organization |
| Biological Process | GO:0048167 | regulation of synaptic plasticity |
| Biological Process | GO:0014894 | response to denervation involved in regulation of muscle adaptation |
| Biological Process | GO:0014850 | response to muscle activity |
| Biological Process | GO:0043434 | response to peptide hormone |
| Biological Process | GO:0098942 | retrograde trans-synaptic signaling by trans-synaptic protein complex |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.