Overview
| Uniprot ID | F1MA52 |
|---|
| Protein Name | Nuclear RNA export factor 1 |
|---|
| Gene Name | Nxf1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 31 |
GRGPFRWKCGEGNRR |
Function
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export
Protein Sequence
10
MADEGKSYNE
20
HDDRVSFPQR
30
RKKGRGPFRW
40
KCGEGNRRSG
50
RGGSGIRSSR
60
FEEDDGDVAM
70
NDPQDGPRVR
80
YNPYTSRPNR
90
RRDTWHDRDR
100
IHVTVRRDRA
110
PQERGGAGTS
120
QDGTTKNWFK
130
ITIPYGKKYD
140
KMWLLSMIQS
150
KCSVPFNPIE
160
FHYENTRAQF
170
FVEDATTASA
180
LKAVNYKIQD
190
RENRRISIII
200
NSSAPPYIVQ
210
NELKPEQVEQ
220
LKLIMSKRYD
230
GSQQALDLKG
240
LRSDPDLVAQ
250
NIDVVLNRRG
260
CMAAALRIIE
270
ENIPELLSLN
280
LSNNRLYKLD
290
DMSSIVQKAP
300
NLKILNLSGN
310
ELKSEWELDK
320
IKGLKLEELW
330
LDRNPMCDTF
340
LDQSTYISTI
350
RERFPKLLRL
360
DGHELPPPIA
370
FDVEAPTMLP
380
PCKGSYFGTE
390
NLKSLVLHFL
400
QQYYAIYDSG
410
DRQGLLDAYH
420
DGACCSLSTP
430
SNPQNPVRHN
440
LAKYFNDSRN
450
VKKIKDTTTR
460
FRLLKHTRLN
470
VVAFLNELPK
480
THHDVNSFVV
490
DISAQTSTLL
500
CFSVNGVFKE
510
VDGKSRDSLR
520
AFTRTFIAVP
530
ASNSGLCIVN
540
DELFVRNASP
550
EEIQRAFAMP
560
APTPSSSPVP
570
TLSQEQQDML
580
QAFSTQSGMN
590
LEWSQKCLQD
600
NNWDYTRSAQ
610
AFTHLKAKGE
IPEVAFMK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0006406 |
mRNA export from nucleus |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.