Search Results
Overview
| Uniprot ID | F1MAJ8 |
|---|---|
| Protein Name | E3 ubiquitin-protein ligase ZFP91 |
| Gene Name | Zfp91 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 173 | NTRSSRSKTGSLQLV |
Function
DNA-binding transcription factor. Also acts as an atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis
Protein Sequence
10
MPGETEEPRS
20
PEQQDQEGGP
30
AAAADAASDE
40
LRSGVAAAAK
50
PAETASSRVL
60
RGGRDRGRTA
70
AAAAAAAVSR
80
RRKAEYPRRR
90
RSSPSNRPPD
100
GHGHQPAAAK
110
PPSPAQGKKS
120
PRLQCIEKIT
130
TDKDPKEEKE
140
DDSVLPQEVS
150
ITATRPSRSW
160
RSSSRTSISR
170
LRDSENTRSS
180
RSKTGSLQLV
190
CKTEPITDQL
200
DYDVPEEHQS
210
PSGISSDEEE
220
EEEEMLISEE
230
EIPFKDDPRD
240
ETYKPHLERE
250
TPKPRRKSGK
260
VKEEKEKKEI
270
KVEVEVEVKE
280
EENEIREDEE
290
PPRKRGRRRK
300
DDKSPRLPKR
310
RKKPPIQYVR
320
CEMEGCGTVL
330
AHPRYLQHHI
340
KYQHLLKKKY
350
VCPHPSCGRL
360
FRLQKQLLRH
370
AKHHTDQRDY
380
ICEYCARAFK
390
SSHNLAVHRM
400
IHTGEKPLQC
410
EICGFTCRQK
420
ASLNWHMKKH
430
DADSFYQFSC
440
NICGKKFEKK
450
DSVVAHKAKS
460
HPEVLIAEAL
470
AANAGALITS
480
TDILGTNPEP
490
LTQPADSQGL
500
PLLPEPLGNS
510
TSGECLLLEA
520
EGMSKSYCSG
530
TERVSLMADG
540
KIFVGSGSSG
550
GTEGLVMNSD
560
ILGATTEVLI
EDTDSTGP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0004842 | ubiquitin-protein transferase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0007250 | activation of NF-kappaB-inducing kinase activity |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0070534 | protein K63-linked ubiquitination |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.