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Overview

Uniprot IDF1REW6
Protein NameZinc finger CCHC domain-containing protein 8
Gene NameZCCHC8
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
753 LRIRNLLKNSPRNQQ

Function

Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing. It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function

Protein Sequence

10 MSQHAMLRSN 20 LRGGSEETPL 30 HSGSCSLTGL 40 ARPLCSSGGL 50 RLGGNPTGWL 60 RSAGAGRAVP 70 PNNLGRRPGG 80 QLRLFSCLFP 90 QPKMAAEVDF 100 GDLELFEAFD 110 HAEESIPKPV 120 HTRFKEDDGD 130 EEDENGVGDA 140 ELRERLRQCE 150 ETVEQLRAEN 160 ILPLELKRKL 170 NILTRPSGIL 180 VNNTKLDGPL 190 LQILFMNNTI 200 FILLLKIYGI 210 MMRPSSVMLQ 220 EDHKVEESSD 230 VQNNKEAFSV 240 VGSVLYFTNF 250 CLDKLGQPLL 260 NENPQLTEGW 270 EIPKYQQVFS 280 HIVSLEGQEI 290 QVKAKRPKPH 300 CFNCGSEEHQ 310 MKDCPMPRNA 320 ARISEKRKEY 330 MDACGETNNQ 340 NFQQRYHAEE 350 VEERFGRFKP 360 GVISEELQDA 370 LGVTDKSLPP 380 FIYRMRQLGY 390 PPGWLKEAEL 400 ENSGLALYDG 410 KDGADGETEA 420 GEVQQNKSVT 430 YDLSKLVNYP 440 GFNISTPRGI 450 PDEWRMFGSI 460 PMQACQQKDV 470 FASYLTSNFQ 480 APSVRSNSKR 490 ASSQSSPSSP 500 KKQKKEGSLA 510 ASPADMELDS 520 DAEVPSNEAF 530 QFQPPLPPGT 540 PPPLPQGTPP 550 PTFTPPLPKG 560 TPPLTPSDSP 570 QTRAASVTMD 580 EDALTLEELE 590 EQQRRIWAAL 600 EQAESVNSDS 610 DIPVDTPLTG 620 NSVASSPCPN 630 ELELPALEEK 640 PSEKQMPDEA 650 EVPDTCTKKS 660 EVEQCSSPDS 670 EAALLDQKEK 680 EASAQVSCKD 690 APLGNGSVKS 700 NCAISNGGGS 710 QKLLHVDTSP 720 ATAPKIHSPI 730 PDMSKFATGI 740 TPFEFENMAE 750 STGMYLRIRN 760 LLKNSPRNQQ KNKKTSE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0031499 TRAMP complex
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0180034 co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway
Biological Process GO:0031124 mRNA 3'-end processing
Biological Process GO:0006396 RNA processing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.