Search Results
Overview
| Uniprot ID | F1RFI1 |
|---|---|
| Protein Name | Elongation factor Tu |
| Gene Name | TUFM |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 202 | LAEGGGAKFKKYEEI |
| 205 | GGGAKFKKYEEIDNA |
| 348 | RDPELGLKSVQKLLD |
| 400 | LERGILKKGDECEFL |
| 425 | TGIEMFHKSLERAEA |
Function
GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Participates in mitochondrial translation. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy
Protein Sequence
10
MSLRGAGVLC
20
GAHRPPAPPE
30
RTAWPLNPRR
40
PGASGKLSSS
50
FPTPEAPASS
60
WTSSVPSPEV
70
DREGHRDSGL
80
EVPKLALSAL
90
TSAGSRFQPQ
100
LPFAWCTRRG
110
PCAVPTVPGA
120
RKTTMAAATL
130
LRATPLFSGL
140
GAGPTSLLQG
150
LLRPLKAPAL
160
PLLCRGLAVE
170
AKKTYVRDKP
180
HVNVGTIGHV
190
DHGKTTLTAA
200
ITKILAEGGG
210
AKFKKYEEID
220
NAPEERARGI
230
TINAAHVEYS
240
TANRHYAHTD
250
CPGHADYVKN
260
MITGTAPLDG
270
CILVVAANDG
280
PMPQTREHLL
290
LAKQIGVEHV
300
VVYVNKADAV
310
QDSEMVELVE
320
LEIRELLTEF
330
GYKGEETPII
340
VGSALCALEQ
350
RDPELGLKSV
360
QKLLDAVDTY
370
IPVPTRDLEK
380
PFLLPVESVY
390
SIPGRGTVVT
400
GTLERGILKK
410
GDECEFLGHS
420
KNIRTVVTGI
430
EMFHKSLERA
440
EAGDNLGALV
450
RGLKREDLRR
460
GLVMAKPGSI
470
QTHQKVEAQV
480
YILSKEEGGR
490
HKPFVSHFMP
500
VMFSLTWDMA
510
CRIILPQGKE
520
LAMPGEDLKL
530
TLILRQPMIL
540
EKGQRFTLRD
550
GNRTIGTGLV
560
TDTPAMTEED
KNIKWS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0003746 | translation elongation factor activity |
| Biological Process | GO:1902775 | mitochondrial large ribosomal subunit assembly |
| Biological Process | GO:0070125 | mitochondrial translational elongation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.