Search Results
Overview
| Uniprot ID | F1RFL6 |
|---|---|
| Protein Name | Translation initiation factor eIF2B subunit alpha |
| Gene Name | EIF2B1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 141 | LEAAVAAKKRFSVYI |
Function
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed
Protein Sequence
10
ELIEYFKSQM
20
KEDPDMASAV
30
AAIRTLLEYL
40
KRDKGETIQG
50
LRANLTSAIE
60
TLCGVDSSVA
70
VSSGGELFLR
80
FISLTSLEYS
90
DYSKCKKIMI
100
ERGEIFLRRI
110
SLSRKKIADM
120
CHTFIKDGAR
130
ILTHAYSRVV
140
LRVLEAAVAA
150
KKRFSVYITE
160
SQPDLSGKKM
170
AKALCHLNVP
180
VTVVLDAAVG
190
LEPTRWPYAP
200
KHRTSLFMLL
210
QRVSSLYGSS
H
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0003743 | translation initiation factor activity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.