Search Results
Overview
| Uniprot ID | F1RFM7 |
|---|---|
| Protein Name | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 |
| Gene Name | AIMP2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 173 | LKCFGEQKQQPRHEY |
| 251 | KEGSSKEKAAVFRSM |
| 64 | SRQDDILKRLYELKA |
| 70 | LKRLYELKAAVDGLS |
Function
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor
Protein Sequence
10
MPMYQVKPYH
20
EGSASLRVEL
30
PTCMYRLPNV
40
HCRTDNPAPA
50
TGHVQEAADP
60
SLQALESRQD
70
DILKRLYELK
80
AAVDGLSKMI
90
QTPDADLDVT
100
NIIQAEEPAA
110
LATSAFDLNS
120
VLGKDYGALK
130
DIVINANPAS
140
PPLSLLVLHR
150
LLCDHYRVLS
160
AVHTHSAVQR
170
VPPHLLKCFG
180
EQKQQPRHEY
190
QLGFTLIWKD
200
VPKTQMKFSV
210
QTMCPIEGEG
220
NIARFLFSLF
230
GRKQDAVSLT
240
LMDSWVDTAV
250
FQLKEGSSKE
260
KAAVFRSMNS
270
ALGKSPWLVG
280
NELTVADVVL
290
WSALRQTGAC
300
GAVVPASVQK
310
WMGACENLAP
FHTALQLLR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0006412 | translation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.