Search Results

Overview

Uniprot ID	F1RFN3
Protein Name	Nuclear receptor corepressor 2
Gene Name	NCOR2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1190	VPGGSITKGLPSTRV
1220	TPADVLYKGTITRII
1253	GHVIYEGKKGHVLSY
1453	STSSTGSKKHDVRSI
1516	VIVPELGKPRQSPLT
1559	EGSLSSSKASQDRKL
1768	GGPTHLTKPTATSSS
1941	AGHTFLAKPPARAGL
1956	EPASSPGKGSEPRPL
1979	AIARTPAKSLAPHHA
2348	RPSSRKAKSPAPGLA
271	INQAMRKKLILYFKR
646	KNFYFNYKKRQNLDE
874	EGSGPGSKGPTAKGS

Function

Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3. Required to activate the histone deacetylase activity of HDAC3. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation

Protein Sequence

10 MSGSTQPVAQ 20 TWRATEPRYP 30 PHGISYPVQI 40 ARPHTDVGLL 50 EYQHHSRDYT 60 SHLSPGSIIQ 70 PQRRRPSLLS 80 EFQPGNERSQ 90 ELHLRPESHA 100 YLPELGKSEM 110 EFLESKRPRL 120 ELLSDPLLRP 130 SPLLAAGQPG 140 GSEDLSKDRS 150 LTGKLEPVSP 160 PSPPHVDPEL 170 ELVPPRLSKE 180 ELIQNMDRVD 190 REITMVEQQI 200 SKLKKKQQQL 210 EEEAAKPPEP 220 EKPVSPPPIE 230 SKHRSLVQII 240 YDENRLSRAS 250 LSLFLQPLYN 260 QPSDTRQYHE 270 NIKINQAMRK 280 KLILYFKRRN 290 HARKQWEQKF 300 CQRYDQLMEA 310 WEKKVERIEN 320 NPRRRAKESK 330 VREYYEKQFP 340 EIRKQRELQE 350 RMQSRVGQRG 360 SGLSMSAARS 370 EHEVSEIIDG 380 LSEQENLEKQ 390 MRQLAVIPPM 400 LYDADQQRIK 410 FINMNGLMDD 420 PMKVYKDRQV 430 MNMWSEQEKE 440 TFREKFMQHP 450 KNFGLIASFL 460 ERKTVAECVL 470 YYYLTKKNEN 480 YKSLVRRSYR 490 RRGKSQQQQQ 500 QQQQQQQQQQ 510 MPRSNQEEKD 520 EKEKEKEAEK 530 EEEKPDVEND 540 KEELIKEKAD 550 DTSGEDNDEK 560 EAVASKGRKT 570 ANSQGRRKGR 580 ITRSMANEAN 590 SEETVTPQQS 600 AELASMEMNE 610 SSRWTEEEME 620 TAKKGLLEHG 630 RNWSAIARMV 640 GSKTVSQCKN 650 FYFNYKKRQN 660 LDEILQQHKL 670 KMEKERNARR 680 KKKKTPAAAS 690 EEAAFPPVVE 700 DEEMEVSGVS 710 GNEEEMAEEA 720 EAAVNNSSDT 730 ESIPSPRTEA 740 AKDTGQNNGP 750 KPPPAPGADA 760 PPPEPPTPPP 770 EDAPAPTEPD 780 PAPEAAGPPT 790 PPPEEKEEEA 800 EAAPSAEEGE 810 EQKPSVAQEL 820 AADVGKTEEP 830 GDTPPSEPVK 840 SECKEEAAEE 850 GPDKVKAGTE 860 AVAEAAPEGA 870 LKVEKKEGSG 880 PGSKGPTAKG 890 SGAPQDSDSS 900 ATCSADEVDE 910 PEGGDKNRLL 920 SPRPSLLTPT 930 SDARTNASPQ 940 KPLDLKQLKQ 950 RAAAIPPIQV 960 TKVHEPPRED 970 TAPPKPAPPA 980 PPAPQHLQPE 990 GDTPQQPSNS 1000 PRGKSRSPVP 1010 PAEKEAEKPV 1020 FFPAFVAEGQ 1030 KLPTDPSCWT 1040 SGLPFPVPPR 1050 EVIKASPHAP 1060 DPLAFSYAPP 1070 GHPLPLGLHD 1080 SARPVLPRPP 1090 TISNPPPLIS 1100 SAKHPSVLER 1110 QMGAISQGMS 1120 VQLHVPYSEH 1130 AKAPVGPITM 1140 GLPLAMDPKK 1150 LAPFSGVKQE 1160 QLSPRGQAGP 1170 PESLGVPTAQ 1180 ETSVLRGTSL 1190 GSVPGGSITK 1200 GLPSTRVPSE 1210 SPITYRGSIT 1220 HGTPADVLYK 1230 GTITRIIGED 1240 SPSRLDRGRE 1250 DGLPKGHVIY 1260 EGKKGHVLSY 1270 EGGMSVSQCS 1280 KEDGRSSSGS 1290 THEAAAPKRT 1300 YDMMEGRVSR 1310 AISSAGIEGL 1320 MGRAIPPERH 1330 SPHHLKEQHH 1340 IRGSITQGIP 1350 RSYVEAQEDY 1360 QRREAKLLKR 1370 EGTPPPPPPP 1380 PRDLAEAYKS 1390 RPLEALGTLK 1400 LKPAHEGLVA 1410 TVKEAGRSIH 1420 EIPREEMRPT 1430 PELPLAPRPL 1440 KEGSITQGTP 1450 LKYDTSTSST 1460 GSKKHDVRSI 1470 IGSPGRTFPP 1480 VHLLDDTRAL 1490 ERACYEESLK 1500 SRPGTVSSSG 1510 GSITRGAPVI 1520 VPELGKPRQS 1530 PLTYEDHAAP 1540 FAGHLPRGSP 1550 VTTREPTPRL 1560 QEGSLSSSKA 1570 SQDRKLTSTP 1580 REIAKSPHST 1590 VPEHHPHPIS 1600 PYEHLLRGVS 1610 GVDLYRSHIP 1620 LAFDPTSIPR 1630 GIPLDAAAAY 1640 YLPRHLAPNP 1650 TYPHLYPPYL 1660 IRGYPDTAAL 1670 ENRQTIINDY 1680 ITSQQMHHNA 1690 ATAMAQRADM 1700 LRGLSPRESS 1710 LALNYAAGPR 1720 GIIDLSQVPH 1730 LPVLVPPTPG 1740 TPATTMDRLT 1750 YLPTAPQHFS 1760 SRLSSSPLSP 1770 GGPTHLTKPT 1780 ATSSSERERE 1790 RDRERERERE 1800 KSILTSTTTV 1810 EHAPIWRPGT 1820 EQGSGGSGGG 1830 GGGGGSSSRP 1840 ASHSHSHQHS 1850 PISPRTQDAI 1860 QQRPSVLHNT 1870 GMKGIVTSVE 1880 PSTPTVLRST 1890 STSSPVRPAA 1900 TFPPATHCPL 1910 GGPLDGVYPT 1920 LVEPVLLPKE 1930 ASRVARPERS 1940 RADAGHTFLA 1950 KPPARAGLEP 1960 ASSPGKGSEP 1970 RPLAPPGSGH 1980 AAIARTPAKS 1990 LAPHHASPDQ 2000 PAPPASAADL 2010 HREKTQSKPF 2020 SIQELELRSL 2030 GYHGGSYSPD 2040 GVEPVSPVSS 2050 PSLTHDKGLP 2060 KHLEELDKSH 2070 LEGDLRHKQP 2080 GPGKLSGEPA 2090 HLPHLRPLPE 2100 SQPSSSPLLQ 2110 TTPGVKGHQR 2120 VVTLAQHISE 2130 VITQDYTRHH 2140 PQQLSAPLPA 2150 PLYSFPGASC 2160 PVLDLRRPPS 2170 DLYLPPPDHG 2180 APARGSPHSE 2190 GGKRSPEPSK 2200 TSALVSGEDG 2210 IEPVSPPEGM 2220 AEPGHPRSAM 2230 YPLLYRDGEQ 2240 AEPSRMGSKS 2250 PGNTSQPPAF 2260 FSKLTESNSA 2270 MVKSKKQEIN 2280 KKLNTHNRNE 2290 PEYNIGQPGT 2300 EIFNMPAITG 2310 AGLMTCRSQA 2320 VQEHASTNMG 2330 LEAIIRKALM 2340 GGGGKAKVSG 2350 RPSSRKAKSP 2360 APGLASGDRP 2370 PSVSSVHSEG 2380 DCNRRTPLTN 2390 RVWEDRPSSA 2400 GSTPFPYNPL 2410 IMRLQAGVMA 2420 SPPPPGLPTG 2430 SGPLAGPHHA 2440 WDEEPKPLLC 2450 SQYETLSDSE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0016363	nuclear matrix
Cellular Component	GO:0017053	transcription repressor complex
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0008047	enzyme activator activity
Molecular Function	GO:0042826	histone deacetylase binding
Molecular Function	GO:0005112	Notch binding
Molecular Function	GO:0003714	transcription corepressor activity
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway
Biological Process	GO:1902894	negative regulation of miRNA transcription
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0010565	regulation of ketone metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.