Search Results
Overview
| Uniprot ID | F1RFY1 |
|---|---|
| Protein Name | Profilin |
| Gene Name | PFN1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 199 | TLVLLMGKEGVHGGM |
| 209 | VHGGMINKKCYEMAS |
| 210 | HGGMINKKCYEMASH |
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR
Protein Sequence
10
TRSRSLPRRR
20
RGRTRCRRLP
30
FLPPQPHSRG
40
SGGARAAAQL
50
AEPRSGRQRV
60
PQALCLPPPA
70
SRGSPSPTRG
80
PSSSPESSPS
90
SSAMAGWNAY
100
IDNLMADGTC
110
QDAAIVGYKD
120
SPSVWAAVPG
130
KTFVNITPAE
140
VGVLVGKDRS
150
SFFVNGLTLG
160
GQKCSVIRDS
170
LLQDGEFTMD
180
LRTKSTGGAP
190
TFNITVTMTA
200
KTLVLLMGKE
210
GVHGGMINKK
220
CYEMASHLRR
SQY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Molecular Function | GO:0003779 | actin binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0032233 | positive regulation of actin filament bundle assembly |
| Biological Process | GO:0030833 | regulation of actin filament polymerization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.