Overview
| Uniprot ID | F1RGS3 |
|---|
| Protein Name | Nuclear cap-binding protein subunit 3 |
|---|
| Gene Name | NCBP3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 446 |
TLSTSNIKNRIGNKL |
Function
Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth
Protein Sequence
10
MAAVRGLRVS
20
VKAEAPAGPA
30
LGPLSPEAES
40
GLDRGEPEPM
50
EVEEGELEIV
60
PVRRSLKELI
70
PDTSRRYENK
80
AGSFITGIDV
90
TSKEAIEKKE
100
QRAKRFHFRS
110
EVNLSQRNVA
120
LDRDMMKKAI
130
PKVRLETIYI
140
CGVDEMSTQD
150
IFSYFKEYPP
160
AHIEWLDDTS
170
CNVVWLDEMT
180
AARALINMSS
190
LPALDKIRSR
200
DASEDKSSEK
210
SKKDKQEDSS
220
DDDEAEEGEV
230
EDENSSDAEL
240
DTLSQVEEES
250
LLRNDLRPAN
260
KLAKGNRLFM
270
RFATKDDKKE
280
LGAARRSQYY
290
MKYGNPNYGG
300
MKGILSNSWK
310
RRYHSRRIQR
320
DVIKKRALIG
330
DDVGLTSYKH
340
RHSGLVNVPE
350
EPIEEEEEEE
360
EEGEDQDMDA
370
DDRVVVEYHE
380
ELPALKQTRE
390
RSTSRRSSAS
400
SSDSDEMDYD
410
LELKMISTPS
420
PKKSMKMTMY
430
ADEVESQLKN
440
IRNSMRADTL
450
STSNIKNRIG
460
NKLPPEKFAD
470
VRHLLDEKRQ
480
HTRPRPPSSN
490
TKTDIRQRLG
500
KRPYSPEKPF
510
SSNPVVRREP
520
FSDVHSRLGV
530
PRQDVKGLYS
540
DTREKKSGSL
550
WTRLGSATKT
560
KEKNTKKVDH
570
RTPGTEEDDS
580
ELQRAWGALI
590
KEKEQSRQKK
600
SRLDNLPSLQ
610
IEVSRESSSG
SEAES
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0000340 |
RNA 7-methylguanosine cap binding |
| Molecular Function |
GO:0000339 |
RNA cap binding |
| Biological Process |
GO:0006370 |
7-methylguanosine mRNA capping |
| Biological Process |
GO:0051607 |
defense response to virus |
| Biological Process |
GO:0006406 |
mRNA export from nucleus |
| Biological Process |
GO:0006408 |
snRNA export from nucleus |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.