Search Results

Overview

Uniprot IDF1RID1
Protein NameElongation factor-like GTPase 1
Gene NameEFL1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1005 RVYAVLSKREGRVLQ
255 FAKIYSQKTGIRKEV
452 ARRRHAEKLAAAQGQ
513 GVARRGKKIFVLGPK

Function

GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export

Protein Sequence

10 MVLNSLDKMI 20 QLQKNTANIR 30 NICVLAHVDH 40 GKTTLADCLI 50 SSNGIISSRL 60 AGKLRYMDSR 70 EDEQIRGITM 80 KSSAISLHYA 90 KDDEEYLINL 100 IDSPGHVDFS 110 SEVSTAVRIC 120 DGCIIVVDAV 130 EGVCPQTQAV 140 LRQAWLENIR 150 PVLVINKIDR 160 LIVELKFTPQ 170 EAYSHLKNIL 180 EQINALTGTL 190 FTSKVLEERA 200 ERVTESQVNP 210 HSEQGEQVYD 220 WSTGLEDTDD 230 SHLYFSPDQG 240 NVVFTSAIDG 250 WGFGIEHFAK 260 IYSQKTGIRK 270 EVLLKTLWGD 280 YYINMKAKKI 290 MKVDQAKGKK 300 PLFVQLILGN 310 IWSLYDAVLK 320 KDKEKIDKIV 330 TSLGLKIGAR 340 EARHSDPKVQ 350 INAICSQWLP 360 ISQAVLAMVC 370 QKLPSPLDIT 380 AERVEKLMCA 390 GSQTFDSLPP 400 ETQALKAAFM 410 KCGSEDTAPV 420 IIFVSKMFAV 430 DAKALPQNKP 440 RPLTPEEIAE 450 RRERARRRHA 460 EKLAAAQGQA 470 PVEPTQDGSA 480 LEASPKEEEP 490 KGDEQQVLQE 500 GNDQESFIAF 510 ARVFSGVARR 520 GKKIFVLGPK 530 YSPLEFLQRV 540 PLGFSAPLDG 550 LPPVPHMACC 560 TLENLYLLMG 570 RELEDLEEVP 580 PGNVLGIGGL 590 QDFVLKSATL 600 CTLPSCPPFI 610 PLNFEATPIV 620 RVAVEPKHPS 630 EMPQLVKGMK 640 LLNQADPCVQ 650 ILIQETGEHV 660 LVTAGEVHLQ 670 RCLDDLKERF 680 AKIQISVSEP 690 IIPFRETITK 700 PPKVDMVNEE 710 IGKQQKVAVI 720 HQTKEDQSKI 730 PEGIQVDSDG 740 LVTITTPNKL 750 ATLCVRAMPL 760 PEEVTQILEE 770 NSDLIRSMEQ 780 LTSSLNEGKN 790 TQVIHQKTQE 800 KIGEFKGRLE 810 QHLTGRKWRN 820 TVDQIWSFGP 830 RKCGPNILVN 840 KSEDFQNSVW 850 TGPDGKASQE 860 ANRYRDLGNS 870 IVSGFQLATL 880 SGPMCEEPLM 890 GVCFVLEKWD 900 LSKFEEQTAS 910 DKQNQKQSDL 920 VDAGQGEGET 930 SSAGDENQEV 940 HNGCSEPFEK 950 RPSQKGESSL 960 TDCYGPFSGQ 970 LIATMKEACR 980 YALQVKPQRL 990 MAAMYTCDIM 1000 ATSDVLGRVY 1010 AVLSKREGRV 1020 LQEEMKEGTD 1030 MFIIKAVLPV 1040 AESFGFADEI 1050 RKRTSGLASP 1060 QLVFSHWEII 1070 PSDPFWVPTT 1080 EEEYLHFGEK 1090 ADSENQARKY 1100 MNAVRKRKGL 1110 YVEEKIVEHA 1120 EKQRTLSKNK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:1990904 ribonucleoprotein complex
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0043022 ribosome binding
Molecular Function GO:0003746 translation elongation factor activity
Biological Process GO:0042256 cytosolic ribosome assembly
Biological Process GO:0046039 GTP metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.