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Overview

Uniprot IDF1RIG2
Protein NameUbiquitin conjugation factor E4
Gene NameUBE4B
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1198 KSTIAIEKFKLLAEK

Function

Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates

Protein Sequence

10 MEELSADEIR 20 RRRLARLAGG 30 QTSQPTTPLT 40 SPQRENPPGP 50 PIAASAPGPS 60 QSLGLNVHSM 70 TPATSPIGAS 80 GVAHRSQSSE 90 GVSSLSSSPS 100 NSLETQSQSL 110 SRSQSMDIDG 120 VSCEKSLSQV 130 DVDSGIENME 140 VDENDRREKR 150 SLSDKEPSSG 160 SEVSEEQALQ 170 LVCKILRVSW 180 KDRDRDVIFL 190 SSLSAQFKQN 200 PKEVFSDFKD 210 LIGQILMEVL 220 MMSTQTRDEN 230 PFASLTATSQ 240 PIAAAARSPD 250 RNLLLNAGSN 260 PGTSPMFCSA 270 GSFGASSLSS 280 LYETSPAPRT 290 SFWSSGPMTS 300 PPLASPSRAA 310 SQAAPGPHGA 320 GAGAPAGSQS 330 PSPRYRPYTV 340 THPWGSSSLC 350 LLSGSPGLPT 360 LASSPQAVPA 370 GSSGPRSSSA 380 GPPLLSASPG 390 AVSRRPASFR 400 SSPSLGASGG 410 ASTWDSYSDH 420 FTIETCKETD 430 MLNYLIECFD 440 RVGIEEKKAP 450 KMCSQPAVSQ 460 LLSNIRSQCI 470 SHTALVLQGS 480 LTQPRSMQQP 490 SFLVPYMLCR 500 NLPYGFIQEL 510 VRTTHQDEEV 520 FKQIFIPILQ 530 GLALAAKECS 540 LDSDYFKYPL 550 MALGELCETK 560 FGKTHPVCNL 570 VASLPLWLPK 580 SLSPGSGREL 590 QRLSYLGAFF 600 SFSVFAEDDA 610 KVVEKYFSGP 620 AITLENTRVV 630 SQSLQHYLEL 640 GRQELFKILH 650 SILLNGETRE 660 AALGYMAAVV 670 NANMKKAQMQ 680 TDDRLVSTDG 690 FMLNFLWVLQ 700 QLSTKIKLET 710 VDPTYIFHPR 720 CRITLPNDET 730 RVNATMEDVN 740 DWLTELYGDQ 750 PPYSEPKFPT 760 ECFFLTLHAH 770 HLSILPSCRR 780 YIRRLRAIRE 790 LNRTVEDLKN 800 NESQWKDSPL 810 ATRHREMLKR 820 CKTQLKKLVR 830 CKACADAGLL 840 DESFLRRCLN 850 FYGLLIQLLL 860 RILDPAYPDV 870 TLPLNSDVPK 880 VFAALPEFYV 890 EDVAEFLFFI 900 VQYSPQVLYE 910 PCTQDIVMFL 920 VVMLCNQNYI 930 RNPYLVAKLV 940 EVMFMTNPAV 950 QPRTQKFFEM 960 IENHPLSTKL 970 LVPSLMKFYT 980 DVEHTGATSE 990 FYDKFTIRYH 1000 ISTIFKSLWQ 1010 NLAHHGTFMD 1020 EFNSGKQFVR 1030 YINMLINDTT 1040 FLLDESLESL 1050 KRIHEVQEEM 1060 KNKEQWDQLP 1070 RDQQQARQSQ 1080 LAQDERVSRS 1090 YLALATETVD 1100 MFHILTKQVQ 1110 KPFLRPELGP 1120 RLAAMLNFNL 1130 QQLCGPKCRD 1140 LKVENPEKYG 1150 FEPKKLLDQL 1160 TDIYLQLDCA 1170 RFAKAIADDQ 1180 RSYSKELFEE 1190 VISKMRKAGI 1200 KSTIAIEKFK 1210 LLAEKVEEIV 1220 AKNARAEIDY 1230 SDAPDEFRDP 1240 LMDTLMTDPV 1250 RLPSGTIMDR 1260 SIILRHLLNS 1270 PTDPFNRQTL 1280 TESMLEPVPE 1290 LKEQIHAWMR EKQNSDH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000151 ubiquitin ligase complex
Molecular Function GO:0034450 ubiquitin-ubiquitin ligase activity
Biological Process GO:0036503 ERAD pathway
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.