Search Results
Overview
| Uniprot ID | F1RIP4 |
|---|---|
| Protein Name | RuvB-like helicase |
| Gene Name | RUVBL2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 166 | IESLTKDKVQAGDVI |
| 214 | CPDGELQKRKEVVHT |
| 259 | VREQINAKVAEWREE |
| 345 | STSPYSEKDTKQILR |
| 348 | PYSEKDTKQILRIRC |
| 397 | SLVCRKRKGTEVQVD |
Function
Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding
Protein Sequence
10
PCSAHSHIRG
20
LGLDDALEPR
30
QASQGMVGQL
40
AARRAAGVVL
50
EMIREGKIAG
60
RAVLIAGQPG
70
TGKTAIAMGM
80
AQALGPDTPF
90
TAIAGSEIFS
100
LEMSKTEALT
110
QAFRRSIGVR
120
IKEETEIIEG
130
EVVEIQIDRP
140
ATGTGSKVGK
150
LTLKTTEMET
160
IYDLGTKMIE
170
SLTKDKVQAG
180
DVITIDKATG
190
KISKLGRSFT
200
RARDYDAMGS
210
QTKFVQCPDG
220
ELQKRKEVVH
230
TVSLHEIDVI
240
NSRTQGFLAL
250
FSGDTGEIKS
260
EVREQINAKV
270
AEWREEGKAE
280
IIPGVLFIDE
290
VHMLDIESFS
300
FLNRALESDM
310
APVLIMATNR
320
GITRIRGTSY
330
QSPHGIPIDL
340
LDRLLIVSTS
350
PYSEKDTKQI
360
LRIRCEEEDV
370
EMSEDAYTVL
380
TRIGLETSLR
390
YAIQLITAAS
400
LVCRKRKGTE
410
VQVDDIKRVY
420
SLFLDESRST
430
QYMKEYQDAF
440
LFNELSEYRP
450
RRPPPPARRP
460
AEGGEPGLES
470
SGPALWATPT
480
TWPSFSPQKA
490
RPWTPPEPTS
500
PSPPPPLFST
RVLTP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0120293 | dynein axonemal particle |
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0031011 | Ino80 complex |
| Cellular Component | GO:0071339 | MLL1 complex |
| Cellular Component | GO:0035267 | NuA4 histone acetyltransferase complex |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0097255 | R2TP complex |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0000812 | Swr1 complex |
| Molecular Function | GO:0043531 | ADP binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0003678 | DNA helicase activity |
| Molecular Function | GO:0140585 | promoter-enhancer loop anchoring activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
| Molecular Function | GO:0017025 | TBP-class protein binding |
| Molecular Function | GO:0001094 | TFIID-class transcription factor complex binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0071392 | cellular response to estradiol stimulus |
| Biological Process | GO:0034644 | cellular response to UV |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0006310 | DNA recombination |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0071169 | establishment of protein localization to chromatin |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:1905168 | positive regulation of double-strand break repair via homologous recombination |
| Biological Process | GO:1904507 | positive regulation of telomere maintenance in response to DNA damage |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0006275 | regulation of DNA replication |
| Biological Process | GO:0060382 | regulation of DNA strand elongation |
| Biological Process | GO:0045995 | regulation of embryonic development |
| Biological Process | GO:0000723 | telomere maintenance |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.