Search Results
Overview
| Uniprot ID | F1RIS8 |
|---|---|
| Protein Name | Mevalonate kinase |
| Gene Name | MVK |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 301 | TKVPRSTKALVASVR |
Function
Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis
Protein Sequence
10
MLSQVLLVSA
20
PGKVILHGEH
30
SVVHGKVALA
40
VALNLRTFLR
50
LQPHNSGKVS
60
LRLPNIGIQQ
70
TWDVARLQLL
80
DTSFLEQGDL
90
TEQVEKLKEV
100
AGFSKDSTNH
110
DCLAVPAFLY
120
LYLTICRSQR
130
TLPSLDIAVW
140
SELPTGAGLG
150
SSAAYSVCLA
160
AALLTACEEI
170
PNPLKDGEAT
180
GRWTEENLEL
190
INKWAFQGER
200
VIHGNPSGVD
210
NAVSTWGGAL
220
RYQQGKISPL
230
KRTHTFLCSG
240
CTVPGPRAIK
250
MDLDLVLGSR
260
NRPAQATERQ
270
RGGCHHEGVP
280
VEQGQSPRKA
290
CGKLPTLEIL
300
LVNTKVPRST
310
KALVASVRNR
320
MLKFPEIIAP
330
LLASMDAISL
340
ECERVLGEMA
350
AAPALEHYLV
360
LEELIDMNQH
370
HLNALGVGHA
380
SLDQLCQVTT
390
AHGLHSKLTG
400
AGGGGCGITL
410
LRPDLERPEV
420
EDTKQALTSC
430
GFDCWETSIG
440
APGVFVHMAA
450
SLDASVQQAL
GDLR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004496 | mevalonate kinase activity |
| Biological Process | GO:0033489 | cholesterol biosynthetic process via desmosterol |
| Biological Process | GO:0033490 | cholesterol biosynthetic process via lathosterol |
| Biological Process | GO:0010142 | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0033386 | geranylgeranyl diphosphate biosynthetic process |
| Biological Process | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0050728 | negative regulation of inflammatory response |
| Biological Process | GO:0036197 | zymosterol biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.