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Overview

Uniprot IDF1RJL2
Protein NameGeneral transcription factor II-I
Gene NameGTF2I
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
130 CYGKALGKSTVVPVP
219 GGSCGPIKVKTEPTE
326 SPPTKRPKSNEPPQP
353 VREFNFEKWNARITD
378 RKYAQAIKAKGPVTI
426 LERILLAKERIRFVI
435 RIRFVIKKHELLNST
456 DKPASGVKEEWYARI
477 VDQLFCKKFAEALGS
526 YGIPRLEKIIQVGNR
573 VRITKLRKQVEEIFN
664 MASKINTKALQSPKR
823 KESTSSSKSPPRKIN

Function

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation

Protein Sequence

10 MAQVAMSTLP 20 VEDEESSESR 30 MVVTFLMSAL 40 ESMCKELAKS 50 KAEVACIAVY 60 ETDVFVVGTE 70 RGRAFVNTRK 80 DFQKDFVKYC 90 VEEEEKAAEM 100 HKMKSTTQAN 110 RMSVDAVEIE 120 TLRKTVEDYF 130 CFCYGKALGK 140 STVVPVPYEK 150 MLRDQSAVVV 160 QGLPEGVAFK 170 HPENYDLATL 180 KWILENKAGI 190 SFIIKRPFLE 200 PKKHLGGRVM 210 VTDTERSMLS 220 PGGSCGPIKV 230 KTEPTEDSGI 240 SLEMAAVTVK 250 EESEDPDYYQ 260 YNIQAGPSET 270 DDVDDKLPLS 280 KSLQGSHHSS 290 EGNEGTEMEV 300 PAEDSTQHVP 310 SETSEDPEVE 320 VTIEDDDYSP 330 PTKRPKSNEP 340 PQPPVTEPAN 350 AGKRKVREFN 360 FEKWNARITD 370 LRKQVEELFE 380 RKYAQAIKAK 390 GPVTIPYPLF 400 QSHVEDLYVE 410 GLPEGIPFRR 420 PSTYGIPRLE 430 RILLAKERIR 440 FVIKKHELLN 450 STREDLQLDK 460 PASGVKEEWY 470 ARITKLRKMV 480 DQLFCKKFAE 490 ALGSTEAKAV 500 PYQKFEAHPN 510 DLYVEGLPEN 520 IPFRSPSWYG 530 IPRLEKIIQV 540 GNRIKFVIKR 550 PELLTHSTTE 560 VTQPRTNTPV 570 KEDWNVRITK 580 LRKQVEEIFN 590 LKFAQALGLT 600 EAVKVPYPVF 610 ESNPEFLYVE 620 GLPEGIPFRS 630 PTWFGIPRLE 640 RIVRGSNKIK 650 FVVKKPELVI 660 SYLPPGMASK 670 INTKALQSPK 680 RPRSPGSNSK 690 VPEIEVTVEG 700 PNNSNPQTSA 710 VRTPTQTNGS 720 NVPFKPRGRE 730 FSFEAWNAKI 740 TDLKQKVENL 750 FNEKCGEALG 760 LKQAVKVPFA 770 LFESFPEDFY 780 VEGLPEGVPF 790 RRPSTFGIPR 800 LEKILRNKAK 810 IKFIIKKPEM 820 FETAIKESTS 830 SSKSPPRKIN 840 SSPNVNTTAS 850 GVEDLNIIQV 860 TIPDDDNERL 870 SKVEKARQLR 880 EQVNDLFSRK 890 FGEAIGMGFP 900 VKVPYRKITI 910 NPGCVVVDGM 920 PPGVSFKAPS 930 YLEISSMRRI 940 LDSAEFIKFT 950 VIRPFPGLVI 960 NNQLVDQNES 970 EGPVIQESSE 980 PSQLEVPATE 990 EIKETDGNSQ IKQEPDPTW

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Biological Process GO:0006366 transcription by RNA polymerase II

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.