Search Results

Overview

Uniprot ID	F1RJM4
Protein Name	TRAF-type zinc finger domain-containing protein 1
Gene Name	TRAFD1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
103	ELSVLKLKDHEDYCG
126	CGRNVLVKDLKTHPE
77	LEKRQLKKHEETECP

Function

Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3

Protein Sequence

10 MAEFLDDQDT 20 RLCDNCKKEI 30 PVFNFTIHEI 40 HCQRNIGMCA 50 ICKEPFPKSD 60 METHMATEHC 70 QVTCKCNKKL 80 EKRQLKKHEE 90 TECPLRLALC 100 QHCDLELSVL 110 KLKDHEDYCG 120 ARTELCGSCG 130 RNVLVKDLKT 140 HPEVCGRNEE 150 EKRDEVTMLP 160 NAYDDSWGQD 170 GIWIASQLRQ 180 IEALDPPMRL 190 PRRPLRAFES 200 DLFQSRTTSQ 210 RSVTAQFPIQ 220 NNLLEEQESQ 230 ERNRRRQTPK 240 EGGEDSANLD 250 FMLALSLQNE 260 GQPPNMAEQD 270 LWRVVCEADQ 280 SHEGPSALND 290 IRGAADGTML 300 PCEFCEELYP 310 EELLIDHQTS 320 CNPSCALPPL 330 GVGSTSPKGM 340 EDPDVIFQEI 350 MQQAARNQLD 360 SLGLRSSPPV 370 EDSIIIPCEF 380 CGVQLEEEVL 390 FHHQDQCDQR 400 PATANNHVSE 410 GIPRQDFQPR 420 GTSPELPKRR 430 VRHQGDLSSD 440 YMDDIKQEMA 450 KGPTYPLPLS 460 RPINNMTATS 470 NRLSVSTSGP 480 RPGCQPSPPR 490 TLKLNNLDNQ 500 GIRGRNRNSH 510 NGALASEQIP 520 AVHPARSLYP 530 ENLVSAFPRG 540 PSGRYGASGR 550 SEGGRNSRVT 560 PTTTSYCSRT 570 VKAKPPKQQG 580 AGDAEEEEEE E

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0045824	negative regulation of innate immune response

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.