Search Results

Overview

Uniprot IDF1RJX8
Protein NameCoatomer subunit alpha
Gene NameCOPA
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1028 KFEEAVEKFRSILLS
1082 KESLEQQKRICEMAA
1119 FFKLKNFKTAATFAR
1134 RLLELGPKPEVAQQT
1143 EVAQQTRKILSACEK
1211 TTVTEIGKDVIGLRI
13 ETKSARVKGLSFHPK
170 DISGLRKKNLSPGAV
238 IWRMNESKAWEVDTC
280 IRVWDMSKRTGVQTF
4 ****MLTKFETKSAR
411 NPDAPEGKRSSGLTA
487 KRTLASVKISKVKYV
517 AIVICNRKLEALCNI
531 IHENIRVKSGAWDES
600 DPTEFKFKLALINRK
607 KLALINRKYDEVLHM
632 IIAYLQKKGYPEVAL
74 VSGGDDYKIKVWNYK
750 SERVRILKNCGQKSL
76 GGDDYKIKVWNYKLR
8 MLTKFETKSARVKGL
81 KIKVWNYKLRRCLFT

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors

Protein Sequence

10 MLTKFETKSA 20 RVKGLSFHPK 30 RPWILTSLHN 40 GVIQLWDYRM 50 CTLIDKFDEH 60 DGPVRGIDFH 70 KQQPLFVSGG 80 DDYKIKVWNY 90 KLRRCLFTLL 100 GHLDYIRTTF 110 FHHEYPWILS 120 ASDDQTIRVW 130 NWQSRTCVCV 140 LTGHNHYVMC 150 AQFHPSEDLV 160 VSASLDQTVR 170 VWDISGLRKK 180 NLSPGAVESD 190 VRGITGVDLF 200 GTTDAVVKHV 210 LEGHDRGVNW 220 AAFHPTMPLI 230 VSGADDRQVK 240 IWRMNESKAW 250 EVDTCRGHYN 260 NVSCAVFHPR 270 QELILSNSED 280 KSIRVWDMSK 290 RTGVQTFRRD 300 HDRFWVLAAH 310 PNLNLFAAGH 320 DGGMIVFKLE 330 RERPAYAVHG 340 NMLHYVKDRF 350 LRQLDFNSSK 360 DVAVMQLRSG 370 SKFPVFNMSY 380 NPAENAVLLC 390 TRASNLENST 400 YDLYTIPKDA 410 DSQNPDAPEG 420 KRSSGLTAVW 430 VARNRFAVLD 440 RMHSLLIKNL 450 KNEITKKVQV 460 PNCDEIFYAG 470 TGNLLLRDAE 480 SITLFDVQQK 490 RTLASVKISK 500 VKYVIWSADM 510 SHVALLAKHA 520 IVICNRKLEA 530 LCNIHENIRV 540 KSGAWDESGV 550 FIYTTSNHIK 560 YAVTTGDYGI 570 IRTLDLPIYV 580 TRVKGNNVYC 590 LDRECRPRVL 600 TIDPTEFKFK 610 LALINRKYDE 620 VLHMVRNAKL 630 VGQSIIAYLQ 640 KKGYPEVALH 650 FVKDEKTRFS 660 LALECGNIEI 670 ALEAAKALDD 680 KNCWEKLGEV 690 ALLQGNHQIV 700 EMCYQRTKNF 710 DKLSFLYLIT 720 GNLEKLRKMM 730 KIAEIRKDMS 740 GHYQNALYLG 750 DVSERVRILK 760 NCGQKSLAYL 770 TAATHGLDEE 780 AENLKETFDP 790 EKETIPDIDP 800 NAKLLQPPAP 810 IMPLDTNWPL 820 LTVSKGFFEG 830 SIASKGKGGA 840 LAADIDIDTV 850 GTEGWGEDAE 860 LQLDEDGFVE 870 ATEGLGDDAL 880 GKGQEEGGGW 890 DVEEDLELPP 900 ELDIPPGAAG 910 GAEDGFFVPP 920 TKGTSPTQIW 930 CNNSQLPVDH 940 ILAGSFETAM 950 RLLHDQVGVT 960 QFGPYKQLFL 970 QTYARGRTTY 980 QALPCLPSMY 990 GYPNRNWKDA 1000 GLKNGIPAVG 1010 LKLNDLIQRL 1020 QLCYQLTTVG 1030 KFEEAVEKFR 1040 SILLSVPLLV 1050 VDNKQEIAEA 1060 QQLITICREY 1070 IVGLSMEIER 1080 KKLPKESLEQ 1090 QKRICEMAAY 1100 FTHSNLQPVH 1110 MILVLRTALN 1120 LFFKLKNFKT 1130 AATFARRLLE 1140 LGPKPEVAQQ 1150 TRKILSACEK 1160 NPTDAYQLNY 1170 DMHNPFDICA 1180 ASYRPIYRGK 1190 PVEKCPLSGA 1200 CYSPEFKGQI 1210 CRVTTVTEIG 1220 KDVIGLRISP LQFR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030126 COPI vesicle coat
Cellular Component GO:0000139 Golgi membrane
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0006891 intra-Golgi vesicle-mediated transport
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.