Search Results

Overview

Uniprot IDF1RK10
Protein NameSuccinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
Gene NameSUCLA2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
30 DEAYAIAKKLGSKDV
359 GTRVDDAKALIADSG
58 GTFESGLKGGVKIVF
62 SGLKGGVKIVFSPEE

Function

ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as an ATP-specific itaconyl- and malyl-CoA synthetase

Protein Sequence

10 MSMELLQEAG 20 VSIPKGHVAK 30 SPDEAYAIAK 40 KLGSKDVVIK 50 AQVLAGGRGK 60 GTFESGLKGG 70 VKIVFSPEEA 80 KAVSSQMIGK 90 KLFTKQTGEK 100 GRICNQVLVC 110 ERRYPRREYY 120 FAITMERSFQ 130 GPVLIGSSQG 140 GVNIEDVAAE 150 TPEAIVKEPI 160 DIVEGIKKEQ 170 AVRLAQKMGF 180 PPSIVDSAAE 190 NMIKLYNLFL 200 KYDATMVEIN 210 PMVEDSDGAV 220 LCMDAKINFD 230 SNSAYRQKKI 240 FDLQDWTQED 250 ERDKDAAKAN 260 LNYIGLDGNI 270 GCLVNGAGLA 280 MATMDIIKLH 290 GGTPANFLDV 300 GGGATVHQVT 310 EAFKLITSDK 320 KVLSILVNIF 330 GGIMRCDVIA 340 QGIVMAVKDL 350 EIKIPIVVRL 360 QGTRVDDAKA 370 LIADSGLKIL 380 ACDDLDEAAK 390 MVVKLSEIVT 400 LAKQAQVDVK FQLPI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0004775 succinate-CoA ligase (ADP-forming) activity
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.