Search Results
Overview
| Uniprot ID | F1RK12 |
|---|---|
| Protein Name | Integral membrane protein 2 |
| Gene Name | ITM2B |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 226 | IYRLCHDKETYKLQR |
Function
Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers
Protein Sequence
10
MVKVTFNSAL
20
AQKEAKKDEP
30
KSGEEALIIP
40
PDTVAVDCKD
50
PDEVVPVGQR
60
RAWCWCMCFG
70
LAFMLAGVIL
80
GGAYLYKYFA
90
LQPDDVYYCG
100
IKYIKDDVIL
110
NEPPANAPAA
120
RYQTIEENIK
130
IFEEDGVEFI
140
SVPVPEFADS
150
DPANIVHDFN
160
KKLTAYLDLN
170
LDKCYVIPLN
180
TSIVMPPRNL
190
LELLINIKAG
200
TYLPQSYLIH
210
EHMVITDRIE
220
NIDHLGFYIY
230
RLCHDKETYK
240
LQRKETVKGI
250
QKREASNCAT
260
IRHFENKFAV
ETLICS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0030660 | Golgi-associated vesicle membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0005524 | ATP binding |
| Biological Process | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.