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Overview

Uniprot IDF1RK45
Protein NameHeat shock protein 75 kDa, mitochondrial
Gene NameTRAP1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
108 EFQAETKKLLDIVAR
336 YVAQAPDKPRYTLHY
381 SVSLYSRKVLIQTKA
425 QESALIRKLQGVLQQ
610 GSRVTNVKVTLRLDT
711 RLNRLLIKALERQ**

Function

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA

Protein Sequence

10 MPSGPSAARG 20 RETHRTGTLA 30 FVQPVDLGLL 40 TAVSPGPGIG 50 NSVLCPRRPP 60 AQSWHPRQCL 70 ASSFHAGRPF 80 SSQAAEDRKE 90 EPPHCIISSS 100 ETVQGSVSKH 110 EFQAETKKLL 120 DIVARSLYSE 130 KEVFIRELIS 140 NASDALEKLR 150 HKLVSEGQTL 160 PEMEIHLQTD 170 SEKGTITIQD 180 TGVGMTREEL 190 VSNLGTIARS 200 GSKAFLDALQ 210 NQAEASGKII 220 GQFGVGFYSA 230 FMVADKVEVY 240 SRSVDAGSPG 250 FQWLSDGSGV 260 FEIAEAAGVR 270 TGTKIIIHLK 280 ADSREFAHEA 290 RVRDVVTKYS 300 NFVSFPLYLN 310 GRRLNTLQAV 320 WMMDPKDVSE 330 EQHEEFYRYV 340 AQAPDKPRYT 350 LHYKTDAPLN 360 IRSIFYVPEM 370 KPSVFDVSRE 380 LGPSVSLYSR 390 KVLIQTKATN 400 ILPTWLRFVR 410 GVVDSEDIPL 420 NLSRELLQES 430 ALIRKLQGVL 440 QQRLIKFFSD 450 QSKKDVEKYA 460 RFFEDYGLFM 470 REGIVTTTEQ 480 EVKEDIAKLL 490 RYESSALPAG 500 QLTSLPDYAS 510 RMQAGTRSIY 520 YLCAPNRHLA 530 EHSPYYEAMK 540 QKNTEVLFCY 550 EQFDELTLLH 560 LREFDRKKLI 570 SVETDIVIDH 580 YKEEKFEDSS 590 PAGDRLSEEE 600 MEDLMAWMRN 610 ALGSRVTNVK 620 VTLRLDTHPA 630 MITVLEMGAA 640 RHFLRMQQLA 650 KTQEERAQLL 660 QPTLEINPRH 670 TLIKKLSQLR 680 HSEPDLAQLL 690 VDQIYENAMI 700 TAGLSDDPRP 710 MVSRLNRLLI KALERQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005759 mitochondrial matrix
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140662 ATP-dependent protein folding chaperone
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0051082 unfolded protein binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.